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24 results for “membrane transporter”
In-depth insights on multi-ionic transport in Electrodialysis with bipolar membrane systems
<p>Electrodialysis with Bipolar Membranes (EDBM) has become a key technology for valorising waste brine streams as a new chemical production route. Even though its application has been widely studied using single electrolyte solutions (e.g., NaCl or Na2SO4), there is still a lack of knowledge about using multi-ionic mixtures. For the first time, this work aims to evaluate the EDBM performance when treating synthetic solutions mimicking the waste brines produced in a integrated process for the valorisation of solar saltworks bitterns. The behaviour of a lab-scale EDBM unit was assessed using SUEZ ion exchange membranes (IEMs), operating at 300 A m− 2, and the ion transport through IEMs was investigated, based on the calculation of apparent transport numbers and selectivities. The results highlighted that multi-ionic solutions barely affected the production of hydroxide ions. Chlorides were transported up to 7 times faster than sulphates across the anion-exchange membranes, while the cation-exchange membranes exhibited slightly higher selectivity for potassium than for sodium (~1.2). The current efficiencies ranged between 70 % and 80 %, while a minimum specific energy consumption of 1.60 kWh kg-1 NaOH was obtained for the most concentrated brine at 1 mol L-1 OH–. These results provide novel and valuable information to support the development and implementation of EDBM as a sustainable technology for supporting a resource-efficient and competitive economy through on-site and delocalized chemicals production routes.</p>
Data in: Aging power spectrum of membrane protein transport and other subordinated random walks
<p>Datasets generated in the report "Aging power spectrum of membrane protein transport and other subordinated random walks". Included data are:</p> <p><strong>Numerical simulations </strong><br> RWdata1.mat: 10,000 realizations, subordinated random walk with Hurst exponent, <em>H</em>=0.3 and <span class="math-tex">\(\alpha\)</span>=0.4.<br> RWdata3.mat: 10,000 realizations, subordinated random walk with Hurst exponent, <em>H</em>=0.7 and <span class="math-tex">\(\alpha\)</span>=0.4.<br> RWdata8.mat: 5,000 realizations, subordinated random walk with Hurst exponent, <em>H</em>=0.75 and <span class="math-tex">\(\alpha\)</span>=0.8.<br> RWdataCTRW.mat: 10,000 realizations, continuous time random walk (CTRW), <span class="math-tex">\(\alpha\)</span>=0.7.</p> <p><strong>Spectra of simulations</strong><br> PSDdata1.mat: Power spectral density (PSD) of a subordinated random walk with Hurst exponent, <em>H</em>=0.3 and <span class="math-tex">\(\alpha\)</span>=0.4. Five different realization times are used to compute the PDS: 2^8, 2^10, 2^12, 2^14, and 2^16.<br> PSDdata3.mat: PSD of a subordinated random walk with Hurst exponent, <em>H</em>=0.7 and <span class="math-tex">\(\alpha\)</span>=0.4. Five different realization times are used to compute the PDS: 2^8, 2^10, 2^12, 2^14, and 2^16.<br> PSDdata8.mat: PSD of a subordinated random walk with Hurst exponent, <em>H</em>=0.75 and <span class="math-tex">\(\alpha\)</span>=0.8. Four different realization times are used to compute the PDS: 2^15, 2^16, 2^17, and 2^18.<br> PSDs_CTRW.mat: PSD of a continuous-time random walk (CTRW), <span class="math-tex">\(\alpha\)</span>=0.7. Five different realization times are used to compute the PDS: 2^8, 2^10, 2^12, 2^14, and 2^16.</p> <p><strong>Experimental data of Nav1.6 channels in the soma of hippocampal neurons</strong><br> NavMSDtimes.csv: ensemble-averaged (EA) MSD and time-averaged (TA) MSD. The TA-MSD is measured for three observation times, 64, 128, and 256 frames (3.2, 6.4, and 12.8 s).<br> NavPSD.csv: Power spectral density (PSD) measured for three observation times, 64, 128, and 256 frames.</p>
X-Ray Diffraction data from Membrane transport protein AcrB, V612F mutant with bound minocycline, source of 9FHC structure
<p>Crystals were grown of the membrane transport protein AcrB, V612F mutant, with bound minocycline. </p> <p>X-ray diffraction data of this upload: 400 frames of 0.5° width were collected on 2007-04-30 at the X06SA beamline of Swiss Light Source at Paul-Scherrer-Institute (Switzerland).</p> <p>The data can be processed with XDS; XDS.INP is provided as part of the upload.</p> <p>The data are the basis of the PDB 9FHC structure.</p>
Lattice Boltzmann simulation of liquid water transport in gas diffusion layers of proton exchange membrane fuel cells: Impact of gas diffusion layer and microporous layer degradation on effective transport properties
<p><span>Underlying data to publication Sarkezi-Selsky et al., <em>J. Pow. Sour.</em> 556 (2023) 232415,<span> https://doi.org/10.1016/j.jpowsour.2022.232415</span> <br><br>Polymer Electrolyte Membrane Fuel Cells (PEMFCs) represent a promising technology for clean drivetrain solutions, in particular for heavy-duty applications. However, lifetime requirements demand high durability of each cell component.<br></span><span>In this work, transport of liquid water through pristine and degraded gas diffusion layers (GDL) was simulated with a 3D Color-Gradient Lattice Boltzmann model. The GDL microstructure was reconstructed </span><span>from high-resolution X-ray micro-computed tomography (</span><span>μ</span><span>-CT) of an impregnated Freudenberg H14. The </span><span>effect of a microporous layer (MPL) was considered by reconstruction of an impregnated and MPL-coated H14. Aged microstructures were generated artificially, assuming loss of polytetrafluoroethylene (PTFE) within the GDL and increase of MPL macroporosity as main degradation mechanisms. Liquid water transport within aged microstructures was simulated by imposing a liquid phase flow rate until breakthrough was reached. Subsequently, the GDL microstructures were analyzed for their breakthrough characteristics by means of saturation and effective gas transport properties. When the MPL was pristine, no distinct GDL degradation effect was observable, this was attributed to the MPL dominating capillary transport. MPL aging, however, led to increased saturations and thus to a deterioration of the effective gas transport. With a partially degraded MPL, aging of the GDL then appeared to affect the breakthrough characteristics.</span></p>
Describing ion transport and water splitting in an electrodialysis stack with bipolar membranes by a 2-D model: Experimental validation
<p>Electrodialysis with bipolar membranes (EDBM) has drawn attention motivated by their application in gener- ating reagents from salts. Due to the water splitting (WS) occurring at the junction of the bipolar membranes (BPMs), where the anion and cation layers are in strict contact, H+ and OH- are released from the BPM producing acid and alkali on the respective compartment. Considering this application, the interest of this work is to provide further understanding of the mechanisms of WS and transport of species in EDBM. This work develops and utilizes, for the first time, an experimentally validated two-dimensional (2-D) computational model, in which the Navier-Stokes and Nernst-Planck equations are coupled with the description of WS given by the Second Wien effect. In addition, a 1-D geometry is also proposed to perform a comparison between electroneutrality and Poisson charge conservation. The model is computationally solved using COMSOL Multiphysics. According to simulations, electroneutrality is valid for 2-D geometries. Moreover, the semipermeable characteristics of the membranes are assessed by means of evidencing a polarization effect resulting in a double-electric layer. The model proposed predicts a significant proton leakage, and facilitates the study of WS within the BPMs.</p>
Data for: In situ generation of (sub) nanometer pores in MoS2 membranes for ion-selective transport
<p>Source data for Fig 1-3 includes data for ion transport measurements and pore size distributions.</p> <p>Source data for Fig. 4 includes trajectory data for molecular dynamics simulations, exclusively for ions within MoS2 nanopores, as well as full trajectory data for the calculation of water-diffusion in 1 nm, 2 nm pores and the bulk reservoir (without an applied electric field). </p>
Data for "Ceramide-1-phosphate transfer protein enhances lipid transport by disrupting hydrophobic lipid–membrane contacts"
<p>Data for "Ceramide-1-phosphate transfer protein enhances lipid transport by disrupting hydrophobic lipid–membrane contacts" by Julia R Rogers and Phillip L Geissler (<a href="https://doi.org/10.1371/journal.pcbi.1010992">Rogers, J. R.; Geissler, P. L. <em>PLoS Comput. Biol.</em> <strong>2023</strong>, <em>19</em>, e1010992</a>; bioRxiv DOI: https://doi.org/10.1101/2022.09.10.507427). All input coordinates, topologies, and parameter files in addition to equilibrium simulation trajectories and analysis results are provided.</p>
PqiC assembles an octameric toroid that stabilises the outer membrane interaction of a putative inter-membrane transport system.
<p>Neutron reflectometry data and custom models used to analyze this data for the article:</p> <p>"PqiC assembles an octameric toroid that stabilises the outer membrane interaction of a putative inter-membrane transport system."</p> <p>The NR data files and the custom models used to fit these using the RasCAL software are provided. </p>
Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury
ClinicalTrials.gov study NCT01322009. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress
<p>The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells. We applied dynamic proteomics to profile protein half-lives and report that INM and ER residents turn over at similar rates, indicating that the INM's unique topology is not a barrier to turnover. Using a microscopy approach, we observed that the proteasome can degrade INM proteins in situ. However, we also uncovered evidence for selective, vesicular transport-mediated turnover of a single INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared from the INM by a mechanism that requires emerin's LEM domain to mediate vesicular trafficking to lysosomes. This work demonstrates that the INM can be dynamically remodeled in response to environmental inputs.</p>
Figures of Conductivity Transitions of La0.7Sr0.3MnO3±d andLa0.6Sr0.4Co0.2Fe0.8O3-d in Ce0.9Gd0.1O2-d Matrix for Dual-Phase Oxygen Transport Membranes
<p>Figures of the article "Conductivity Transitions of La0.7Sr0.3MnO3±d andLa0.6Sr0.4Co0.2Fe0.8O3-d in Ce0.9Gd0.1O2-d Matrix for Dual-Phase Oxygen Transport Membranes"</p>
Optimal transport and model (Membrane-cortex-tension)
<p>Optimal Transport and model (Membrane Cortex Tension)</p>
Bone Transport Through Induced Membrane vs Conventional Bone Transport in Management of Bone Defects of Lower Limbs
ClinicalTrials.gov study NCT05631951. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress
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Data from: DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content
Lactose provides an easily-digested energy source for neonate mammals, and is the primary carbohydrate in milk. Lactose is also a key component of many human food products, though compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we present the first GWAS of milk lactose concentration and yield, investigated in a population of 12,000 taurine dairy cattle. We detail 27 QTL spanning these traits, and subsequently validate the effects of 26 of these loci in a separate population of 18,000 cows. We next present data implicating causative genes and variants for these QTL. Fine mapping of these regions using imputed, whole genome sequence-resolution genotypes reveals protein-coding candidate causative variants affecting the ABCG2, DGAT1, STAT5B, KCNH4, NPFFR2 and RNF214 genes. Eleven of the remaining QTL appear to be driven by regulatory effects, suggested by the presence of co-locating, co-segregating eQTL discovered using mammary RNA sequence data representing a population of 357 lactating cows. Pathway analysis of genes representing all lactose-associated loci shows significant enrichment of genes located to the endoplasmic reticulum, with functions related to ion channel activity mediated through the LRRC8C, P2RX4, KCNJ2 and ANKH genes. Together, these findings highlight novel candidate genes and variants involved in milk lactose regulation, whose impacts on facilitated and active membrane transport mechanisms reinforce the key osmo-regulatory roles of lactose in milk.
Pnictogen-Bonding Catalysis Compared to Ion Transport in Lipid Bilayer Membranes: Original Data
<p>Original data underlying the publication. Data are arranged according to the supporting information. </p>
Data from: DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content
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SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters
GEO Series GSE251776. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Missense mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins to cause hemolysis
GEO Series GSE240553. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis
GEO Series GSE94351. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.