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61 results for “metabolic requirement”
Data from: Quantifying the ecological role of crocodiles: A 50-year review of metabolic requirements and nutrient contributions in Northern Australia
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A simple method reveals minimum time required to quantify steady-rate metabolism and net cost of transport for human walking
<p>The U-shaped net cost of transport (COT) curve of walking has helped scientists understand the biomechanical basis that underlies energy minimization during walking. However, to produce an individual's net COT curve, data must be analyzed during periods of steady-rate metabolism. Traditionally, studies analyze the last few minutes of a 6–10 min trial, assuming that steady-rate metabolism has been achieved. Yet, it is possible that an individual achieves steady rates of metabolism much earlier. However, there is no consensus on how to objectively quantify steady-rate metabolism across a range of walking speeds. Therefore, we developed a simple slope method to determine the minimum time needed for humans to achieve steady rates of metabolism across slow to fast walking speeds.We hypothesized that a shorter time window could be used to produce a net COT curve that is comparable to the net COT curve created using traditional methods. We analyzed metabolic data from 21 subjects who completed several 7 min walking trials ranging from 0.50 to 2.00 m s−1. We partitioned the metabolic data for each trial into moving 1, 2 and 3 min intervals and calculated their slopes. We statistically compared these slope values with values derived from the last 3 min of the 7 min trial, our 'gold' standard comparison. We found that a minimum of 2 min is required to achieve steady-rate metabolism and that data from 2–4 min yields a net COT curve that is not statistically different from the one derived from experimental protocols that are generally accepted in the field.</p>
A simple method reveals minimum time required to quantify steady-rate metabolism and net cost of transport for human walking
Open the record for dataset details and reuse information.
Non- Essential Amino Acid Requirements and Metabolism in Humans
ClinicalTrials.gov study NCT02009917. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost
1. Many animals experience periods of food shortage in their natural environment. It has been hypothesised that the metabolic responses of animals to naturally-occurring periods of food deprivation may have long-term negative impacts on their subsequent life-history. 2. In particular, reductions in energy requirements in response to fasting may help preserve limited resources but potentially come at a cost of increased oxidative stress. However, little is known about this trade-off since studies of energy metabolism are generally conducted separately from those of oxidative stress. 3. Using a novel approach that combines measurements of mitochondrial function with in vivo levels of hydrogen peroxide (H2O2) in brown trout (Salmo trutta), we show here that fasting induces energy savings in a highly metabolically active organ (the liver) but at the cost of a significant increase in H2O2, an important form of reactive oxygen species (ROS). 4. After a 2-week period of fasting, brown trout reduced their whole-liver mitochondrial respiratory capacities (state 3, state 4 and cytochrome c oxidase activity), mainly due to reductions in liver size (and hence the total mitochondrial content). This was compensated for at the level of the mitochondrion, with an increase in state 3 respiration combined with a decrease in state 4 respiration, suggesting a selective increase in the capacity to produce ATP without a concomitant increase in energy dissipated through proton leakage. However, the reduction in total hepatic metabolic capacity in fasted fish was associated with an almost two-fold increase in in vivo mitochondrial H2O2 levels (as measured by the MitoB probe). 5. The resulting increase in mitochondrial ROS, and hence potential risk of oxidative damage, provides mechanistic insight into the trade-off between the short-term energetic benefits of reducing metabolism in response to fasting and the potential long-term costs to subsequent life-history traits.
Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)
ClinicalTrials.gov study NCT05320653. IPD Sharing: NO. Countries: 0. Publications: 1.
Data from: Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost
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Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation [I]
GEO Series GSE209678. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The mevalonate pathway is required for pyrimidine synthesis and survival of p53-deficient colon cancer cells in metabolically compromised environments
GEO Series GSE124189. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
TWIST1 is required for HSC maintenance under steady state and stress condition by inhibiting mitochondrial metabolism gene program
GEO Series GSE133682. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Fat graft survival requires metabolic reprogramming towards glycolytic pathway
GEO Series GSE203599. Mus. 15 samples. Type: Expression profiling by high throughput sequencing.
Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF [RNA-seq]
GEO Series GSE180306. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth [scRNA-seq]
GEO Series GSE264261. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Muscle mitochondrial stress-induced metabolic adaptations do not require FGF21 action
GEO Series GSE71749. Mus musculus. 40 samples. Type: Expression profiling by array.
Cell autonomous requirement of Neurofibrimin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis
GEO Series GSE147605. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional analysis of developing Aspergillus fumigatus biofilms reveals metabolic shifts required for biofilm maintenance
GEO Series GSE298422. Aspergillus fumigatus. 12 samples. Type: Expression profiling by high throughput sequencing.
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth [bulk RNA-seq]
GEO Series GSE264260. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
AoSte12 is required for mycelial development, conidiation, trap morphogenesis, and secondary metabolism by regulating hyphal fusion in nematode-trapping fungus of Arthrobotrys oligospora [gene express
GEO Series GSE213447. Orbilia oligospora. 12 samples. Type: Expression profiling by high throughput sequencing.
One carbon metabolism is required for epigenetic stability in the mouse placenta
GEO Series GSE233438. Mus musculus. 35 samples. Type: Methylation profiling by high throughput sequencing.
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth.
GEO Series GSE264262. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.