Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2
datasets available to search
ShareScore release 0.9.0
Dataset results
2 results for “miRNA-103/107”
MiRNA-103/107 in primary high-grade serous ovarian cancer and its clinical significance
<p>High levels of miRNA-103/107 are associated with poor outcome in case of breast cancer patients. MiRNA-103/107- DICER axis may be one of the key regulators of cancer aggressiveness. MiRNA-103/107 expression levels have never been related to patients' survival in epithelial ovarian cancer. We aimed to assess miRNA-103/107 expression levels in high grade serous ovarian cancer tissues. Expression levels of both miRNAs were related to the clinicopathological features and survival. We also evaluated expression levels of miRNA-103/107 and DICER in selected ovarian cancer cell lines (A2780, A2780cis, SK-OV-3, OVCAR3).</p> <p>We assessed relative expression of miRNA-103/107 (quantitative reverse transcription polymerase chain reaction) in fifty archival formalin-fixed paraffin embedded tissue samples of primary high grade serous ovarian cancer . Then, miRNA-103/107 and DICER expression levels were evaluated in selected ovarian cancer cells lines. Additionally, DICER, N-/E-cadherin protein levels were assessed with the use of western blot.</p> <p>We identified miRNA-107 up-regulation in ovarian cancer in comparison to healthy tissues (p=0.0005). In case of miRNA-103, we did not observe statistically significant differences between cancerous and healthy tissues (p=0.07). We did not find any correlations between miRNA-103/107 expression levels and clinicopathological features. Kaplan-Meier survival (disease free and overall survival) analysis revealed that both miRNAs cannot be considered as prognostic factors. SK-OV-3 cancer cell lines was characterised by high expression of miRNA-103/107, relatively low expression of DICER (western-blot) and relatively high N-cadherin levels in comparison to other ovarian cancer cell lines.</p> <p>Clinical and prognostic significance of miRNA-103/107 was not confirmed in our study.</p>
MiRNA-103/107 in primary high-grade serous ovarian cancer and its clinical significance
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.