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Dataset results
19 results for “microbleeds”
Factor XII deletion mitigates cerebral microbleed load but not hemodynamic dysfunction in the arcAβ mice
<p>Cerebrovascular dysfunction and a prothrombotic state have been found in patients with Alzheimer’s disease (AD). The factor XII (FXII)-driven activated contact system has been implicated in the vascular pathology and inflammation in AD patients and AD mouse models. Here we investigated the effect of genetic deletion of <em>FXII</em> on AD-related vascular dysfunction using magnetic resonance imaging (MRI). AD mouse line ArcAβ, arcAβ/<em>FXII-/-</em>, <em>FXII-/-</em> and non-transgenic littermates of 17 months of age (n = 40) were assessed for 1) cerebral microbleeds (CMB) load using susceptibility weighted imaging (SWI) MRI, 2) cerebral blood flow (CBF) using arterial spin labeling, and 3) vascular reactivity by estimating changes in cerebral blood volume (∆CBV) during hypercapnic stimulus using acetazolamide.</p>
Low-dose Aspirin Therapy in Patients With Ischemic Stroke and Microbleeds
ClinicalTrials.gov study NCT04504864. IPD Sharing: NO. Countries: 1. Publications: 14.
Cerebral Microbleeds During NOACs or Warfarin Therapy in NVAF Patients With Acute Ischemic Stroke (CMB-NOW)
ClinicalTrials.gov study NCT02356432. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds
ClinicalTrials.gov study NCT05589454. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Relevance of Microbleeds In Stroke
ClinicalTrials.gov study NCT02513316. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Antithrombotic Drug Use in Patients With Ischemic Stroke and Microbleeds
ClinicalTrials.gov study NCT05032053. IPD Sharing: NO. Countries: 1. Publications: 14.
Association of common genetic variants with brain microbleeds: A genome-wide association study
<p><strong>Objective:</strong> To identify common genetic variants associated with the presence of brain microbleeds (BMB).</p> <p><strong>Methods:</strong> We performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMB were rated on susceptibility-weighted or T2*-weighted gradient echo magnetic resonance imaging sequences, and further classified as lobar, or mixed (including strictly deep and infratentorial, possibly with lobar BMB). In a subset, we assessed the effects of <em>APOE</em> ε2 and ε4 alleles on BMB counts. We also related previously identified cerebral small vessel disease variants to BMB.</p> <p><strong>Results: </strong>BMB were detected in 3,556 of the 25,862 participants, of which 2,179 were strictly lobar and 1,293 mixed. One locus in the <em>APOE</em> region reached genome-wide significance for its association with BMB (lead SNP rs769449; OR<sub>any BMB</sub> (95% CI)=1.33 (1.21-1.45); p=2.5x10-10). <em>APOE</em> ε4 alleles were associated with strictly lobar (OR (95% CI)=1.34 (1.19- 1.50); p=1.0x10-6) but not with mixed BMB counts (OR (95% CI)=1.04 (0.86-1.25); p=0.68). <em>APOE</em> ε2 alleles did not show associations with BMB counts. Variants previously related to deep intracerebral hemorrhage and lacunar stroke, and a risk score of cerebral white matter hyperintensity variants, were associated with BMB.</p> <p><strong>Conclusions: </strong>Genetic variants in the <em>APOE</em> region are associated with the presence of BMB, most likely due to the <em>APOE</em> ε4 allele count related to a higher number of strictly lobar BMB. Genetic predisposition to small vessel disease confers risk of BMB, indicating genetic overlap with other cerebral small vessel disease markers.</p>
Microbleeds, cerebral hemorrhage, and functional outcome after endovascular thrombectomy
<p><b>Objective</b>—To determine <span>whether the presence, number, and distribution of cerebral microbleeds (CMBs) on </span>pretreatment MRI <span>scans are associated with an increased risk of intracerebral hemorrhage (ICH) or poor functional outcome </span>following <span>endovascular thrombectomy (EVT)</span> for <span>acute ischemic stroke (AIS).</span></p> <p><b>Methods</b>—We analyzed prospectively collected data of consecutive patients treated by <span>EVT</span> for AIS, in a comprehensive stroke center where MRI is the first-line pretreatment imaging. Neuroradiologists blinded to clinical data rated CMBs on T2* sequence using a validated scale. <span>We investigated associations of pre-treatment CMB presence, burden (1, 2–4, and ≥5), and presumed pathogenesis with ICH and poor 3-month functional outcome (modified Rankin score >2)</span>.</p> <p><b>Results</b>—Among 513 patients, <span>281 (54.8%) had a poor outcome</span> and 89 (17.3%) had ≥1 CMBs. <span>A total of 190 (37%) patients experienced ICH, in which 66 (12.9%) were symptomatic. </span>CMB burden was associated with worse outcome in a univariable analysis (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.03–1.36 per 1-CMB increase; P=0.02), but significance was lost after adjustment for age, sex, baseline stroke severity, hypertension, <span>diabetes mellitus</span>, atrial fibrillation, prior antithrombotic medication, intravenous thrombolysis, and reperfusion status (OR, 1.05; 95% CI, 0.92–1.20 per 1-CMB increase; P=0.50). Results remained nonsignificant when taking into account CMB location or presumed underlying vasculopathy. CMB presence, burden, location, nor presumed underlying vasculopathy was independently associated with ICH.</p> <p><b>Conclusions</b>—Poor outcome or ICH was not associated with CMB presence or burden on pre–EVT MRI after adjustment for confounding factors. Excluding such patients from reperfusion therapies is unwarranted.</p>
Gender Heterogeneity in the Influencing Factors for Cerebral Microbleeds in Acute Ischemic Stroke Patients
ClinicalTrials.gov study NCT05882123. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Trial of Apixaban vs Warfarin in Reducing Rate of Cognitive Decline, Silent Cerebral Infarcts and Cerebral Microbleeds in Patients With Atrial Fibrillation
ClinicalTrials.gov study NCT03839355. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Microbleeds, cerebral hemorrhage, and functional outcome after endovascular thrombectomy
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Association of common genetic variants with brain microbleeds: A genome-wide association study
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SPATIAL TRANSCRIPTOMICS IDENTIFY HOMOLOGOUS MECHANISMS IN THE PATHOPHYSIOLOGY OF HUMAN AND E4FAD MOUSE CEREBRAL MICROBLEEDS
GEO Series GSE288162. Mus musculus; Homo sapiens. 31 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Severe Congenital Hemostatic Defects, Cerebral MIcrobleeds and COGnition
ClinicalTrials.gov study NCT06090201. IPD Sharing: NO. Countries: 0. Publications: 0.
The Impact of Anti-thrombosis on Cerebral Microbleeds and Intracranial Hemorrhage in Ischemic Stroke Patients
ClinicalTrials.gov study NCT03571763. IPD Sharing: NO. Countries: 1. Publications: 0.
Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
ClinicalTrials.gov study NCT01723553. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cilostazol vs. Aspirin in Acute Non-cardioembolic Stroke With Cerebral mIcrobleeds
ClinicalTrials.gov study NCT06530537. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Predictors of new remote cerebral microbleeds after intravenous thrombolysis for ischemic stroke
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MRI Detection of Microbleeds in Glioma Patients
ClinicalTrials.gov study NCT02899663. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.