Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7
datasets available to search
ShareScore release 0.9.0
Dataset results
7 results for “microhaplotype”
Population genetics characteristics of a 90 locus panel of microhaplotypes
<p>Microhaplotype genotype data for 556 individuals (with anonymized identifiers) from 16 population samples.</p> <p> </p>
Data from: Microhaplotypes provide increased power from short-read DNA sequences for relationship inference
Open the record for dataset details and reuse information.
The application of short and highly polymorphic microhaplotypes based on nonbinary-SNPs in kinship testing of extremely degraded samples
<p>Kinship testing becomes more difficult in extremely degraded samples. But commonly used genetic markers cannot completely solved this problem. Microhaplotype combining the advantages of STR and SNP may be a promising genetic marker for kinship testing in extremely degraded samples. Therefore, in this study, 36 short and highly polymorphism microhaplotype loci with length smaller than 100 bp and Ae greater than 3.0 were developed, of which 29 loci met the Hardy-Weinberg and linkage equilibrium. The CPD and CPE of these 29 loci were 0.99999999999999999999999997036 and 0.9999999945, respectively. Allele dropout of these loci was not observed in extremely degraded samples. Through simulated kinship analysis, the effectiveness of paternity testing reached 98.39% at threshold of 4/-4, and effectiveness of full-sibling testing reached 93.01% at threshold of 2/-2, which were greater than that of 15 STR loci. After combining with other 50 short and highly polymorphic microhaplotype loci, the effectiveness of half-sibling testing also reached 82.42% at the threshold of 2/-2. Our developed short and highly polymorphic microhaplotype loci may be useful for paternity testing and full-sibling testing in extremely degraded samples, and after combining with other short and highly polymorphic microhaplotype loci, may be helpful to analyze the more distant kinship relationship.</p>
Transitioning from microsatellites to SNP-based microhaplotypes in genetic monitoring programs: lessons from a 20-year time series of paired data.
<p>Many long-term genetic monitoring programs began before next-generation sequencing became widely available. Older programs can now transition to new marker systems usually consisting of 1000s of SNP loci, but there are still important questions about comparability, precision, and accuracy of key metrics estimated using SNPs. Ideally, transitioned programs should capitalize on new information without sacrificing continuity of inference across the time series. We combined existing microsatellite-based genetic monitoring information with SNP-based microhaplotypes obtained from archived samples of Rio Grande silvery minnow (<em>Hybognathus amarus</em>) across a 20-year time series to evaluate point estimates and trajectories of key genetic metrics. Demographic and genetic monitoring bracketed multiple collapses of the wild population, and included cases where captive-born repatriates comprised the majority of spawners in the wild. Even with smaller sample sizes, microhaplotypes yielded comparable and in some cases more precise estimates of variance genetic effective population size, multilocus heterozygosity and inbreeding compared to microsatellites because many more microhaplotype loci were available. Microhaplotypes also recorded shifts in allele frequencies associated with population bottlenecks. Trends in microhaplotype-based inbreeding metrics were associated with the fraction of hatchery-reared repatriates to the wild, and should be incorporated into future genomic monitoring. Although differences in accuracy and precision of some metrics were observed between marker types, biological inferences and management recommendations were consistent.</p>
Transitioning from microsatellites to SNP-based microhaplotypes in genetic monitoring programs: lessons from a 20-year time series of paired data.
Open the record for dataset details and reuse information.
The application of short and highly polymorphic microhaplotypes based on nonbinary-SNPs in kinship testing of extremely degraded samples
Open the record for dataset details and reuse information.
North Pacific harbor porpoise SNP and microhaplotype genotypes, mitochondrial control region haplotype sequences
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.