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26 results for “mitochondrial fusion”
Data from: Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora
The replication and segregation of the multi-copy mitochondrial DNA (mtDNA) are not under strict control of the nuclear DNA. Within-cell selection may thus favour variants with an intracellular selective advantage but a detrimental effect on cell fitness. High relatedness among the mtDNA variants of an individual is predicted to disfavour such deleterious selfish genetic elements, but experimental evidence for this hypothesis is scarce. We studied the effect of mtDNA relatedness on the opportunities for suppressive mtDNA variants in the fungus Neurospora carrying the mitochondrial mutator plasmid pKALILO (pKAL). During growth, this plasmid integrates into the mitochondrial genome, generating suppressive mtDNA variants. These mtDNA variants gradually replace the wild-type mtDNA, ultimately culminating in growth arrest and death. We show that regular sequestration of mtDNA variation is required for effective selection against suppressive mtDNA variants. First, bottlenecks in the number of mtDNA copies from which a 'Kalilo' culture started significantly increased the maximum lifespan and variation in life span among cultures. Second, restrictions to somatic fusion among fungal individuals, either by using anastomosis-deficient mutants or by generating allotype diversity, prevented the accumulation of suppressive mtDNA variants. We discuss the implications of these results for the somatic accumulation of mitochondrial defects during ageing.
Data from: Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora
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Acetyl-CoA Carboxylase-1 Inhibition Increases Regulatory T-Cell Metabolism, Mitochondrial Fusion and Graft-vs-Host Disease Treatment Efficacy [L2_cGvHD]
GEO Series GSE296708. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial fusion limits breast cancer metastasis
GEO Series GSE245216. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
Transriptional effects of blocking mitochondrial fission-fusion in aging Drosophila clock neurons
GEO Series GSE275587. Drosophila melanogaster. 24 samples. Type: Expression profiling by high throughput sequencing.
Mitochondria-selective primate cell fusions reveal functional consequences of mitochondrial divergence
GEO Series GSE270085. Pan troglodytes; Pongo abelii; Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation
GEO Series GSE217644. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Next generation sequencing reveals no change in mtDNA deletions upon the loss of mitochondrial fusion in mouse hearts
GEO Series GSE124420. Mus musculus. 7 samples. Type: Other.
DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma
GEO Series GSE253465. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma
GEO Series GSE233148. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Acetyl-CoA Carboxylase-1 Inhibition Increases Regulatory T-Cell Metabolism, Mitochondrial Fusion and Graft-vs-Host Disease Treatment Efficacy
GEO Series GSE294218. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Targeting Mitochondrial Fusion and Fission to Prevent Atherosclerosis: Getting the Balance Right
ClinicalTrials.gov study NCT03980548. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Mitochondrial fusion drives oxidative metabolism to immortalize neural stem cells during tumorigenesis
GEO Series GSE154203. Drosophila melanogaster. 384 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis revealed that crizotinib-induced cardiomyocyte death, and cardiac dysfunctionapoptosis is related to autophagosome-lysosome fusion and mitochondrial injury
GEO Series GSE210150. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
OPA1 mutations associated with dominant optic atrophy affect mitochondrial fusion and cell death in a domain-specific manner
GEO Series GSE289826. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia.
GEO Series GSE222169. Homo sapiens. 42 samples. Type: Expression profiling by array.
The Injections of Mitochondrial Fusion Promoter M1 during Proestrus Disrupt the Progesterone Secretion and the Estrous Cycle in the Mouse.
GEO Series GSE213529. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
MT-targeted MT1/2 orchestrates mitochondrial fusion dynamics-mediated WNT/β-catenin signaling to promote DA neuronal differentiation of human iPS and nerve regeneration in PD mice
GEO Series GSE295508. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [PDX shOPA1]
GEO Series GSE222168. Homo sapiens. 12 samples. Type: Expression profiling by array.
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [PDX MFN2 OE]
GEO Series GSE222166. Homo sapiens. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.