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Dataset results
24 results for “mitral valve disease”
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
<p>The behavior of the comprehensive circulating renin‐angiotensin system (RAS) in dogs with myxomatous mitral valve disease (MMVD) before the onset of congestive heart failure remains largely unexplored.</p> <p>Hypothesis/Objectives: The classical and alternative RAS activity and aldosterone concentrations will be significantly higher in dogs with American College of Veterinary Internal Medicine (ACVIM) stage B2 MMVD compared to normal dogs and dogs with ACVIM stage B1 MMVD.</p> <p>Animals: One hundred seventeen client‐owned dogs (normal = 60; B1 = 31; B2 = 26).</p> <p>Methods: Prospective observational study. Angiotensin peptides (AP) and aldosterone concentrations were measured using liquid chromatography and mass spectrometry. Angiotensin converting enzymes 1 and 2 (ACE, ACE2) and renin activity surrogates were calculated from AP concentrations. Equilibrium dialysis (ED) and immediate protease inhibition (PI) methods of AP quantification were compared in 14 healthy dogs.</p> <p>Results: Core RAS activity and aldosterone concentrations did not differ among the 3 groups. However, the balance between the alternative and classical RAS differed, with dogs with stage B2 MMVD having significantly higher ACE2 activity surrogate (ACE2surr) when compared to normal dogs (adjusted P = .02; ratio of medians for ACE2surr [B2:normal], 1.89; 95% confidence interval [CI]: 1.4‐2.6). The ED and PI methods of AP quantification were highly correlated (AngI, r = .9, P < .0001; AngII, r = .8, P = .001).</p> <p>Conclusions and Clinical Importance: Circulating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.</p>
The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study
ClinicalTrials.gov study NCT03155373. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
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Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases
ClinicalTrials.gov study NCT02721524. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Bi-atrial Versus Left Atrial Ablation for Patients With Rheumatic Mitral Valve Disease and Non-paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT05021601. IPD Sharing: NO. Countries: 1. Publications: 1.
Transcatheter Treatment for Combined Aortic and Mitral Valve Disease. The Aortic+Mitral TRAnsCatheter (AMTRAC) Valve Registry
ClinicalTrials.gov study NCT04031274. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
A Registry Study of Biomarkers in Mitral Valve Disease (BIOMS-MVD)
ClinicalTrials.gov study NCT05141292. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease (TORCH-M)
ClinicalTrials.gov study NCT04954404. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery
ClinicalTrials.gov study NCT02925819. IPD Sharing: NO. Countries: 1. Publications: 10.
Data from: Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease
Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypothesized that valvular interstitial cells (VICs) undergo disease-relevant changes in miRNA expression. In primary VIC lines from diseased and control valves, miRNA expression was profiled using RT-qPCR and next generation sequencing. VICs from diseased valves showed phenotypic changes consistent with myofibroblastic differentiation (vimentinlow+, a-SMAhigh+), increases in senescence markers (p21, SA-b-gal), and decreased cell viability and proliferation potential. RT-qPCR and miRNA sequencing analyses both showed significant (p<0.05) downregulation of let-7c, miR-17, miR-20a, and miR-30d in VICs from diseased valves compared to controls. Decreased let-7c, miR-17, and miR-20a may contribute to myofibroblastic differentiation in addition to cell senescence, and decreased miR-30d may disinhibit cell apoptosis. These data support the hypothesis that epigenetic dysregulation plays an important role in age-related canine MMVD.
Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease
ClinicalTrials.gov study NCT03278574. IPD Sharing: NO. Countries: 0. Publications: 1.
Data from: Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease
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Transcriptomic profiling study of canine degenerative mitral valve disease
GEO Series GSE64544. Canis lupus familiaris. 12 samples. Type: Expression profiling by high throughput sequencing.
Abbott Cephea Mitral Valve Disease Registry
ClinicalTrials.gov study NCT07069673. IPD Sharing: NO. Countries: 1. Publications: 0.
The Study on the Use of "UniLine" Bioprosthesis in the Treatment of Isolated Aortic and Mitral Valve Diseases
ClinicalTrials.gov study NCT06025149. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease.
ClinicalTrials.gov study NCT07243184. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study on Efficacy, Safety and Durability of the UniLine Prosthesis in the Treatment of Aortic and Mitral Valve Disease
ClinicalTrials.gov study NCT05895487. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Outcomes of Mitral Valve Surgery in Patients Affected by Rheumatic Heart Disease
ClinicalTrials.gov study NCT04780607. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Effect of RT3D-TEE-guided Mitral Valve Repair on Outcomes in Patients With Degenerative Mitral Valve Disease
ClinicalTrials.gov study NCT05595226. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Bosentan Improves Clinical Outcome of Adults With Congenital Heart Disease or Mitral Valve Lesions Who Undergo CArdiac Surgery
ClinicalTrials.gov study NCT01184404. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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OpenNeuro
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