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ShareScore release 0.9.0
Dataset results
15 results for “molecular chaperone”
Controlling the Supramolecular Polymerization of Squaraine Dyes by a Molecular Chaperone Analogue
<p>ABSTRACT: Molecular chaperones are proteins that assist in the (un)folding and (dis)assembly of other macromolecular structures toward their biologically functional state in a non-covalent manner. Transferring this concept from nature to artificial self-assembly processes, here, we show a new strategy to control supramolecular polymerization via a chaperone-like two-component system. A new kinetic trapping method was developed that enables efficient retardation of the spontaneous self-assembly of a squaraine dye monomer. The suppression of supramolecular polymerization could be regulated with a cofactor, which precisely initiates self-assembly. The presented system was investigated and characterized by ultraviolet–visible, Fourier transform infrared, and nuclear magnetic resonance spectroscopy, atomic force microscopy, isothermal titration calorimetry, and single-crystal X-ray diffraction. With these results, living supramolecular polymerization and block copolymer fabrication could be realized, demonstrating a new possibility for effective control over supramolecular polymerization processes.</p>
Assessing protein refolding by molecular chaperones using smFRET and luciferase refolding assays
<p>Dataset contains (predominantly) pre-processed data for single-molecule FRET (smFRET) and luciferase refolding assays. For smFRET experiments, the conformation of individual luciferase (FlucIDS) proteins was monitored in real-time and incubated either in the presence of chemical denaturant or in the presence of various combinations and concentrations of molecular chaperones from the bacterial Hsp70 system (i.e., DnaJ, DnaK and GrpE). Similarly, the ability of this chaperone system to refold FlucIDS to an enzymatically active state was assessed using luciferase refolding assays. Owing to the size of the raw .TIF images generated during smFRET experiments, only a subset of these representative raw images are provided (see figure 1C, 2M GdHCl treatment) that can be used to perform the analysis from its earliest starting point.</p> <p>Note: data required for Figures S4, S5 and S6 are provided in Figure 2, 3 and 4, respectively.</p> <p>Note 2: Within each figure is a txt document that outlines the format and meaning of each dataset.</p>
Modeling of the bacterial molecular chaperone GroEL using 3D EM data and cnmultifit
<p>These scripts demonstrate the use of IMP, MODELLER and Chimera in the modeling of the bacterial molecular chaperone GroEL. First, MODELLER is used to generate structures for the individual components in the GroEL complex. Then, IMP is used to fit these components together into the electron microscopy density map of the entire complex.</p>
Evolution of the conformational dynamics of the molecular chaperone Hsp90
<p>MD snapshots from: "Evolution of the conformational dynamics of the molecular chaperone Hsp90"</p> <p> </p>
The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
GEO Series GSE40255. Saccharomyces cerevisiae. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cardiac Myofibrillogenesis 1 is Spatiotemporally Modulated by the Molecular Chaperone UNC45B
GEO Series GSE229229. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Molecular Chaperone RUVBL2 Activates Oncogenes by Modulation of Transcriptional Condensates [ChIP-Seq]
GEO Series GSE160738. Homo sapiens; Mus musculus. 41 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Molecular Chaperone RUVBL2 Activates Oncogenes by Modulation of Transcriptional Condensates [PRO-Seq]
GEO Series GSE160696. Mus musculus. 6 samples. Type: Other.
Molecular Chaperone RUVBL2 Activates Oncogenes by Modulation of Transcriptional Condensates [RNA-Seq]
GEO Series GSE160698. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
DNAJC9 Integrates Heat Shock Molecular Chaperones into the Histone Chaperone Network
GEO Series GSE154445. Homo sapiens. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Molecular Chaperone RUVBL2 Activates Oncogenes by Modulation of Transcriptional Condensates
GEO Series GSE160739. Mus musculus; Homo sapiens. 69 samples. Type: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing.
Heat-shock molecular chaperone Hsp90 is involved in heterochromatin assembly in Schizosaccharomyces pombe.
GEO Series GSE140617. Schizosaccharomyces pombe. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Molecular Chaperone RUVBL2 Activates Oncogenes by Modulation of Transcriptional Condensates [Mnase-seq]
GEO Series GSE185347. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Hsp27 acts as a master molecular chaperones and plays an essential role in hepatocellular carcinoma metastasis
GEO Series GSE38080. Homo sapiens. 3 samples. Type: Expression profiling by array.
Coordinated regulation of protein synthesis and mitochondrial respiration by the molecular chaperone TRAP1 in cancer cells
GEO Series GSE141616. Homo sapiens. 24 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.