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4 results for “multiple risks and benefits”
Supplemental data for "Inequitable spatial and temporal patterns in the distribution of multiple environmental risks and benefits in Metro Vancouver"
<p><strong>DemoEnPoC2016.csv/DemoEnPoC2006.csv:</strong></p> <p>This is a table including environmental and demographic (Census variables) data at postal code level for Metro Vancouver in the year 2006 and 2016. The environmental data (SO2 metrics, PM2.5 metrics, Calculated ozone metrics, NO2 data, NDVI metrics, and Canadian Active Living Environments Index (Can-ALE) indexed to DMTI Spatial Inc. postal codes) were extracted from CANUE (Canadian Urban Environmental Health Research Consortium). The demographic data is extracted from Canadian Census analyzer (https://datacentre.chass.utoronto.ca/), the deprivation index is downloaded from from the Institut national de santé publique du Québec (INSPQ). </p> <p><strong>DGRwithLable:</strong></p> <p>This is the Dissemination Geographies Relationship File for the 2021 census year (Statistics Canada, 2021) with the lable of urban or rural, indicating which dissemination area (DA) is identified as urban and included in this study. The urban area is named as population certer. </p> <p><strong>Aggregation and SS Determination:</strong></p> <p>This script contains code for:</p> <ul> <li>Aggregating postal code level data to the Dissemination Area (DA) level.</li> <li>Eliminating rural DAs.</li> <li>Converting environmental data into ordinal categories using quartile and even break methods.</li> <li>Identifying sweet and sour spots for each DA based on these methods.</li> </ul> <p><strong>SSEJ Analysis:</strong></p> <p>This script includes code for:</p> <ul> <li>Creating violin and box plots to illustrate descriptive statistics of demographic groups across different environmental categories (sweet, sour, risky, and medium).</li> <li>Performing linear regression analyses between environmental categories and demographic variables.</li> </ul> <p><strong>SS Heatmap:</strong></p> <p>This script comprises code for:</p> <ul> <li>Summarizing the results of the linear regression analyses.</li> <li>Assessing changes in inequities among demographic groups between 2006 and 2016.</li> <li>Visualizing regression coefficients through heatmaps.</li> </ul> <p> </p>
Data from: Quantitative benefit-risk assessment of methylprednisolone in multiple sclerosis relapses
Background: High-dose short-term methylprednisolone is the recommended treatment in the management of multiple sclerosis relapses, although it has been suggested that lower doses may be equally effective. Also, glucocorticoids are associated with multiple and often dose-dependent adverse effects. This quantitative benefit-risk assessment compares high- and low-dose methylprednisolone (at least 2000 mg and less than 1000 mg, respectively, during at most 31 days) and a no treatment alternative, with the aim of determining which regimen, if any, is preferable in multiple sclerosis relapses. Methods: An overall framework of probabilistic decision analysis was applied, combining data from different sources. Effectiveness as well as risk of non-serious adverse effects were estimated from published clinical trials. However, as these trials recorded very few serious adverse effects, risk intervals for the latter were derived from individual case reports together with a range of plausible distributions. Probabilistic modelling driven by logically implied or clinically well motivated qualitative relations was used to derive utility distributions. Results: Low-dose methylprednisolone was not a supported option in this assessment; there was, however, only limited data available for this treatment alternative. High-dose methylprednisolone and the no treatment alternative interchanged as most preferred, contingent on the risk distributions applied for serious adverse effects, the assumed level of risk aversiveness in the patient population, and the relapse severity. Conclusions: The data presently available do not support a change of current treatment recommendations. There are strong incentives for further clinical research to reduce the uncertainty surrounding the effectiveness and the risks associated with methylprednisolone in multiple sclerosis relapses; this would enable better informed and more precise treatment recommendations in the future.
Data from: Quantitative benefit-risk assessment of methylprednisolone in multiple sclerosis relapses
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Communicating Multiple Uncertainties Associated With the Benefits and Risks of New Cancer Drugs
ClinicalTrials.gov study NCT07110597. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.