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45 results for “muscarine”
Phylogenetic analysis, morphological studies, element profiling, and muscarine detection reveal a new toxic Inosperma (Inocybaceae, Agaricales) species from tropical China
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Atropine-functionalised gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium
<p>Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation. For the present project, spherical gold nanoparticles were synthesised and functionalised with the muscarinic receptor antagonist atropine (Au-MUDA-AT NPs). The diameter of the gold core could precisely be controlled by using different synthetic methods and reducing agents resulting in functionalised gold nanoparticles with diameters ranging from 8 to 16 nm. The ability to interact with intestinal muscarinic receptors is size-dependent. When using intestinal chloride secretion induced by the stable acetylcholine derivative, carbachol, as read-out, the strongest inhibition, i.e. the most efficient blockade of muscarinic receptors, was observed with 13 nm sized Au-MUDA-AT NPs. Functional experiments indicate that Au-MUDA-AT NPs with a diameter of 14 nm are able to pass the intestinal mucosa in a time-dependent manner after administration to the intestinal lumen. For example, luminally administered Au-MUDA-AT NPs inhibited contractions of the small intestinal longitudinal muscle layer induced by electrical stimulation of myenteric neurons. A similar inhibition of basolateral epithelial receptors was observed after luminal administration of Au-MUDA-AT NPs when using carbachol-induced chloride secretion across the intestinal epithelium as a test system. Thus, Au-MUDA-AT NPs might be a therapeutic tool for the modulation of intestinal secretion and motility after oral application in the future.</p>
Raw diffraction images of human muscarinic acetylcholine receptor
<p>Raw data for <a href="https://www.rcsb.org/structure/5ZK8">5ZK8</a> (M<sub>2</sub>-BRIL–NMS), <a href="https://www.rcsb.org/structure/5ZKC">5ZKC</a> (S110R-BRIL–NMS), <a href="https://www.rcsb.org/structure/5ZKB">5ZKB</a>(S110R-BRIL–AF-DX 384), and <a href="https://www.rcsb.org/structure/5ZK3">5ZK3</a> (S110R-BRIL–QNB). </p>
An Investigation Of The Interaction Of GSK961081 With Inhaled Beta-Agonist And Anti-Muscarinic Drugs.
ClinicalTrials.gov study NCT00674817. IPD Sharing: YES. Countries: 3. Publications: 1.
Atropine-functionalised gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium
Open the record for dataset details and reuse information.
Raw diffraction images of mercury-bound human muscarinic acetylcholine receptor
<p>Raw data for <a href="https://www.rcsb.org/structure/5YC8">5YC8</a> (S110R-BRIL–NMS:Hg).</p>
Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death from Any Cause
ClinicalTrials.gov study NCT05563675. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluation of Long-Acting Muscarinic Antagonists in COPD
ClinicalTrials.gov study NCT02039050. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium
ClinicalTrials.gov study NCT03097380. IPD Sharing: NO. Countries: 1. Publications: 2.
Duration of Long Acting Muscarinic Antagonist (LAMA) Bronchoprotection Against Methacholine Challenge
ClinicalTrials.gov study NCT02622243. IPD Sharing: YES. Countries: 1. Publications: 1.
Muscarinic Receptor Antagonists as a Therapy for Diabetic Neuropathy
ClinicalTrials.gov study NCT03050827. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys
Activation of the muscarinic M1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M1-selective positive allosteric modulator that improves cognitive deficits induced by scopolamine, a non-selective muscarinic receptor antagonist, with reduced side effects on gastrointestinal function in rats. In this study, we explored changes in quantitative electroencephalography (qEEG) power bands, with or without scopolamine challenge, as a non-invasive translational biomarker for the effect of TAK-071 in cynomolgus monkeys. Scopolamine has been reported to increase theta and delta power bands and decrease alpha power band in healthy volunteers. In line with the clinical observations, scopolamine (25‒100 μg/kg, subcutaneous administration [s.c.]) increased theta and delta power bands in cynomolgus monkeys in a dose-dependent manner, whereas it had the opposite effect on alpha power band. The effects of TAK-071 on scopolamine (25 μg/kg, s.c.)-induced qEEG spectral changes were examined using an acetylcholinesterase inhibitor donepezil and a muscarinic M1/M4 receptor agonist xanomeline as comparative cholinomimetics. TAK-071 (0.3‒3 mg/kg, oral administration [p.o.]), donepezil (3 mg/kg, p.o.), and xanomeline (1 mg/kg, s.c.) suppressed the scopolamine-induced increases in alpha, theta, and delta power bands. These results suggest that changes in specific qEEG power bands, in particular theta and delta power bands in the context of scopolamine challenge, could be used as translational biomarkers for the evaluation of TAK-071 in clinical studies.
Figure 6 from: Deng L-S, Kang R, Zeng N-K, Yu W-J, Chang C, Xu F, Deng W-Q, Qi L-L, Zhou Y-L, Fan Y-G (2021) Two new Inosperma (Inocybaceae) species with unexpected muscarine contents from tropical China. MycoKeys 85: 87-108. https://doi.org/10.3897/mycokeys.85.71957
Figure 6 The comparisons of the two new species in their outline of basidiospores and cheilocystidia shape a, c basidiospores and cheilocystidia of I. hainanense (FHMU3162, holotype); b, d Basidiospores and cheilocystidia of I. muscarium (FHMU3166, holotype). Scale bars: 10 μm (a–d). Photos by L.-S. Deng
Figure 5 from: Deng L-S, Kang R, Zeng N-K, Yu W-J, Chang C, Xu F, Deng W-Q, Qi L-L, Zhou Y-L, Fan Y-G (2021) Two new Inosperma (Inocybaceae) species with unexpected muscarine contents from tropical China. MycoKeys 85: 87-108. https://doi.org/10.3897/mycokeys.85.71957
Figure 5 Microscopic features of Inosperma hainanense (FHMU3166, holotype) a–b basidiospores c–d basidia e–k cheilocystidia in clusters l pileipellis and pileal trama n hymenophoral trama m, o oleiferous hyphae p stipitipellis and stipe trama. Scale bars: 10 μm (a–k). Photos by L.-S. Deng
Figure 4 from: Deng L-S, Kang R, Zeng N-K, Yu W-J, Chang C, Xu F, Deng W-Q, Qi L-L, Zhou Y-L, Fan Y-G (2021) Two new Inosperma (Inocybaceae) species with unexpected muscarine contents from tropical China. MycoKeys 85: 87-108. https://doi.org/10.3897/mycokeys.85.71957
Figure 4 Basidiomata of Inosperma hainanensea–e basidiomata f–g rimose to rimulose pileus h lamellae i lamellae edge j–k stipe surface. c FHMU3166 (holotype) a–b, d–g, i–k FHMU6511 h FHMU3168. Scale bars: 10 mm (a–k). a–b, d–k: photos by L.-S. Deng; c: photos by N.-K. Zeng
Figure 3 from: Deng L-S, Kang R, Zeng N-K, Yu W-J, Chang C, Xu F, Deng W-Q, Qi L-L, Zhou Y-L, Fan Y-G (2021) Two new Inosperma (Inocybaceae) species with unexpected muscarine contents from tropical China. MycoKeys 85: 87-108. https://doi.org/10.3897/mycokeys.85.71957
Figure 3 Microscopic features of Inosperma muscarium (FHMU3162, holotype) a–b basidiospores c–d basidia e–h cheilocystidia in clusters i oleiferous hyphae j pileipellis and pileal trama k terminal hyphae at the stipe apex l hymenophoral trama m stipitipellis and stipe trama. Scale bars: 10 μm (a–m). Photos by L.-S. Deng
Figure 1 from: Deng L-S, Kang R, Zeng N-K, Yu W-J, Chang C, Xu F, Deng W-Q, Qi L-L, Zhou Y-L, Fan Y-G (2021) Two new Inosperma (Inocybaceae) species with unexpected muscarine contents from tropical China. MycoKeys 85: 87-108. https://doi.org/10.3897/mycokeys.85.71957
Figure 1 Phylogram generated by Bayesian Inference (BI) analyses based on sequences of a combined data set from nuclear genes (rDNA-ITS, nrLSU, and rpb2), rooted with Auritella hispida and A. spiculosa. Bayesian Inference posterior probabilities (BI-PP) ≥0.95 and ML bootstrap proportions (ML-BP) ≥70 are represented as BI-PP/ML-BP. I. muscarium sp. nov. and I. hainanense sp. nov. are two newly described taxa.
Figure 2 from: Deng L-S, Kang R, Zeng N-K, Yu W-J, Chang C, Xu F, Deng W-Q, Qi L-L, Zhou Y-L, Fan Y-G (2021) Two new Inosperma (Inocybaceae) species with unexpected muscarine contents from tropical China. MycoKeys 85: 87-108. https://doi.org/10.3897/mycokeys.85.71957
Figure 2 Basidiomata of Inosperma muscariuma–e basidiomata f–h rimose to rimulose pileus i lamellae j–k lamellae edge l–m stipe surface. a–b, d, f–g, i–m FHMU3162 (holotype) c, e FYG6092 (FHMU3163) h FYG6093 (FHMU3164). Scale bars: 10 mm (a–m). Photos by Y.-G. Fan.
Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART-II) Trial
ClinicalTrials.gov study NCT01178827. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART) Trial
ClinicalTrials.gov study NCT00863551. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.