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160 results for “myocardium”
Bioactive compounds from Crataegus Oxycantha Protects myocardium against important proteins of atherosclerosis. An in-depth analysis using molecular simulation studies
<p>We are submitting this data as a raw file for the submission of our manuscript to the peer reviwed journals. </p>
Full-Length Spatial Transcriptomics Reveals the Unexplored Isoform Diversity of the Myocardium Post-MI
<p>We introduce Single-cell Nanopore Spatial Transcriptomics (scNaST), a software suite to facilitate the analysis of spatial gene expression from second- and third-generation sequencing, allowing to generate a full-length near-single-cell transcriptional landscape of the tissue microenvironment. Taking advantage of the Visium Spatial platform, we adapted a strategy recently developed to assign barcodes to long-read single-cell sequencing data for spatial capture technology. Here, we demonstrate our workflow using four short axis sections of the mouse heart following myocardial infarction. We constructed a <em>de novo</em> transcriptome using long-read data, and successfully assigned 19,794 transcript isoforms in total, including clinically-relevant, but yet uncharacterized modes of transcription, such as intron retention or antisense overlapping transcription. We showed a higher transcriptome complexity in the healthy regions, and identified intron retention as a mode of transcription associated with the infarct area. Our data revealed a clear regional isoform switching among differentially used transcripts for genes involved in cardiac muscle contraction and tissue morphogenesis. Molecular signatures involved in cardiac remodeling integrated with morphological context may support the development of new therapeutics towards the treatment of heart failure and the reduction of cardiac complications.</p>
X-ray diffraction patterns of the effects of dATP on permeabilized porcine myocardium
<p>X-ray and mechanical experiments were performed using permeabilized porcine left ventricle wall muscle. The frozen muscle was thawed in skinning solution at room temperature before dissection into smaller strips and skinned at room temperature for 3 hours. Permeabilized fiber bundles were further dissected into preparations with a length of 4 mm with a diameter of 200 µm prior to attachment of aluminum T-clips to both ends for X-ray experiments. X-ray diffraction patterns were collected at BioCAT beamline on a MarCCD 165 detector (Rayonix Inc., Evanston IL) with a 1 s exposure time as a function of five increasing dATP compositions (0%, 2%, 10%, 25%, and 100%) with the total NTP concentration (dATP + ATP) remaining constant at 2.5 mM after 10 min incubation in each solution.</p>
Carbetocin Myocardium Trial 2014 Part 2
ClinicalTrials.gov study NCT03899961. IPD Sharing: NO. Countries: 1. Publications: 2.
RHYTHM (Formerly Escape II Myocardium)
ClinicalTrials.gov study NCT01548768. IPD Sharing: NO. Countries: 1. Publications: 1.
Reduction of Ischemic Myocardium With Ranolazine-Treatment in Patients With Acute Myocardial Ischemia
ClinicalTrials.gov study NCT01797484. IPD Sharing: YES. Countries: 1. Publications: 10.
Tolerance of Myocardium to Ischemia Injury
ClinicalTrials.gov study NCT02812901. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Manganese-Enhanced Magnetic Resonance Imaging of the Myocardium
ClinicalTrials.gov study NCT03607669. IPD Sharing: NO. Countries: 1. Publications: 1.
The Clinical Carbetocin Myocardium Trial
ClinicalTrials.gov study NCT02528136. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction
ClinicalTrials.gov study NCT05292404. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium
ClinicalTrials.gov study NCT02851433. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium
ClinicalTrials.gov study NCT00326989. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effect of EPLerenone on Ischemia Reperfusion Injury in Human myoCARDium
ClinicalTrials.gov study NCT02118753. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
ClinicalTrials.gov study NCT02670031. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure
ClinicalTrials.gov study NCT04396899. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Remote Ischemic Preconditioning of Human Myocardium
ClinicalTrials.gov study NCT01994707. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Randomized Clinical Trial of Adipose-derived Stem Cells in Treatment of Non Revascularizable Ischemic Myocardium
ClinicalTrials.gov study NCT00426868. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Speckle Tracking Echocardiography Analysis of Left Ventricular Myocardium After Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy
ClinicalTrials.gov study NCT04777188. IPD Sharing: Not stated. Countries: 1. Publications: 1.
POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
ClinicalTrials.gov study NCT04899635. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Viable Myocardium Detected by Hybrid PET/MR and SPECT for the Prediction of the Efficacy of PCI in Patients With CTO.
ClinicalTrials.gov study NCT06113835. IPD Sharing: NO. Countries: 1. Publications: 10.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.