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29 results for “natural antibodies”
Data from: Natural selection on antihelminth antibodies in a wild mammal population
<p>An effective immune response is expected to confer fitness benefits through improved resistance to parasites but also energetic costs which negatively impact fitness-related traits such as reproduction. These fitness costs and benefits of an immune response are likely to depend on host age, sex, and levels of parasite exposure. Few studies have examined the full extent to which patterns of natural selection on immune phenotypes vary across demographic groups and environments in the wild. Here, we assessed natural selection on plasma levels of three functionally distinct isotypes (IgA, IgE and IgG) of antibodies against a prevalent nematode parasite measured in a wild Soay sheep population over 25 years. We found little support for environment-dependent selection or reproductive costs. However, antibody levels were negatively associated with parasite egg counts and positively associated with subsequent survival, albeit in a highly age- and isotype-dependent manner. Raised levels of anti-parasite IgA best predicted reduced egg counts but this did not predict survival in lambs, whilst in adult females increased anti-parasite IgG predicted reduced egg counts and improved survival. Our results highlight the potential importance of age-dependent selection on immune phenotypes in nature, and that patterns of selection can vary even amongst functionally-related immune markers.</p>
Data from: Natural selection on antihelminth antibodies in a wild mammal population
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Dataset Associated with "Biochemical and biophysical characterization of natural polyreactivity in antibodies"
<p>Processed data for recreating figures and statistical analysis from Borowska & Boughter et al. <em>Cell Reports</em> 2023. Scripts for creating the figures and analysis from these data, as well as the scripts used to generate these datasets, can be found on the GitHub page (https://github.com/ctboughter/manuscript_md_analysis)</p>
Natural Killer(NK) Cell Combined With Programmed Death-1(PD-1) Antibody as Second Line Therapy for Advanced Driver Mutation Negative Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT03958097. IPD Sharing: NO. Countries: 1. Publications: 2.
Deep Characterization of the Human Antibody Response to Natural Infection Using Longitudinal Immune Repertoire Sequencing
GEO Series GSE123158. Homo sapiens. 210 samples. Type: Other.
Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition of Ph(-like) acute lymphoblastic leukemia (scRNA-Seq)
GEO Series GSE268064. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomics of Chronic Active Antibody-Mediated Rejection of Human Kidney Allografts and Identification of Intragraft Overexpression of Natural Kill Cell Cytotoxicity Gene Set
GEO Series GSE232825. Homo sapiens. 57 samples. Type: Expression profiling by high throughput sequencing.
Proliferative Receptor Binding Domain (RBD)-specific CD4+ T cells correlate with neutralizing antibody levels after natural SARS-CoV-2 infection and are induced following vaccination
GEO Series GSE198281. Homo sapiens; synthetic construct. 6 samples. Type: Expression profiling by high throughput sequencing.
Unleashing natural IL-18 activity using an anti-IL-18BP blocker antibody induces potent immune stimulation and anti-tumor effects
GEO Series GSE239473. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
CD47 in the tumor microenvironment and CD47 antibody blockade regulate natural killer cell recruitment and activation
GEO Series GSE113876. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Fc receptor-like 6 (FCRL6) defines pre-BCR dependent and independent pathways of natural antibody selection
GEO Series GSE132438. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition of Ph(-like) acute lymphoblastic leukemia (MethylationEPIC)
GEO Series GSE268065. Homo sapiens. 14 samples. Type: Methylation profiling by array.
Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition of Ph(-like) acute lymphoblastic leukemia (RNA-Seq)
GEO Series GSE268063. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Memory-like natural killer cell and CD19-antibody based immunotherapy in combination with tyrosine-kinase inhibition of Ph(-like) acute lymphoblastic leukemia
GEO Series GSE268066. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by array.
Data from: Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions
Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2–3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.
Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma
ClinicalTrials.gov study NCT02650648. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Children
ClinicalTrials.gov study NCT01214538. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Efficacy and Safety of Chidamide, Anti-PD-1 Antibody in Combination With Pegaspargase Versus DDGP in the Treatment of Newly Diagnosed, Stage III to IV Extranodal Natural Killer/T-Cell Lymphoma
ClinicalTrials.gov study NCT06255795. IPD Sharing: NO. Countries: 1. Publications: 0.
A Multicenter, Phase 3, Randomized Trial of Sequencial Chemoradiotherapy with or Without Toripalimab (PD-1 Antibody) in Newly Diagnosed Early-Stage Extranodal Natural Killer/T Cell Lymphoma, Nasal Typ
ClinicalTrials.gov study NCT04365036. IPD Sharing: NO. Countries: 1. Publications: 0.
Anti-GD2 3F8 Antibody and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma
ClinicalTrials.gov study NCT00877110. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.