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602 results for “natural killer cell”
Datasets: Natural killer cells associate with malignant epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment
<p>The following are necessary data files for the manuscript "Natural killer cells associate with malignant epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment":</p> <ul> <li>.zip files for TMA_1, TMA_2, TMA_3, and TMA_4 are .mcd files acquired from imaging mass cytometry (IMC) for each slide of the pancreas TMA slide series</li> <li>pancreas_TMA_sample_info.xlxs includes info on all samples of the TMA slide series that were imaged by IMC</li> <li>custom_gates_0.zip includes histoCAT-derived single cell data files from all IMC samples in the pancreas TMA to be used for single cell analyses in R</li> <li>PDAC_IMC.RDS is a Seurat object of the IMC-derived PDAC single cell data to use for single cell and spatial analyses</li> <li>PDAC_sce is a SingleCellExperiment object of IMC-derived PDAC single cell data to use for spatial analyses</li> <li>mat.RDS is a distance matrix of PDAC cell types to use in R to generate network graph (Figure 2)</li> </ul> <p> </p> <p> </p>
Supporting transcriptomic data and code for: "Rapid and dose-dependent Natural Killer (NK) cell modulation and cytokine correlations after human rVSV-ZEBOV Ebolavirus vaccination"
<p>The counts_NK.csv file contains gene expression data (counts) for genes in the Ion Ampliseq human Gene expression kit panel. Data were obtained from whole blood RNA. Subjects were vaccinated with a high dose of the rVSV-ZEBOV vaccine against Ebola virus disease in the Geneva clinical trial.</p> <p>The Descriptive_Table_NK_2.csv contains descriptive data of the subjects for differential expression analysis.</p> <p>The NK_analysis_code.R file contains the code used for analysis.</p>
Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.
<p><strong>Abstract</strong> </p> <p>Natural Killer (NK) cells are innate lymphocytes with central roles in immunosurveillance and are implicated in autoimmune pathogenesis. The degree to which regulatory variants affect NK gene expression is poorly understood. We performed expression quantitative trait locus (eQTL) mapping of negatively selected NK cells from a population of healthy Europeans (n=245). We find a significant subset of genes demonstrate eQTL specific to NK cells and these are highly informative of human disease, in particular autoimmunity. An NK cell transcriptome-wide association study (TWAS) across five common autoimmune diseases identified further novel associations at 27 genes. In addition to these <em>cis</em> observations, we find novel master-regulatory regions impacting expression of <em>trans</em> gene networks at regions including 19q13.4, the Killer cell Immunoglobulin-like Receptor (KIR) Region, <em>GNLY</em>, <em>MC1R</em> and<em> UVSSA</em>. Our findings provide new insights into the unique biology of NK cells, demonstrating markedly different eQTL from other immune cells, with implications for disease mechanisms.</p> <p><strong>Preprint</strong></p> <p>https://www.biorxiv.org/content/10.1101/2021.05.10.443088v1</p> <p><strong>Dataset</strong></p> <p>nk_raw_for_zenodo.txt: Matrix of raw gene expression at 47,209 probes in primary human NK cells from 245 healthy individuals of European ancestry. Gene expression is quantified using the Illumina HumanHT-12 v4 BeadChip gene expression array platform. Column names represent Array Address ID for each probe, and row names represent pseudonymised sample identifiers, which can be matched to sample genotypes. Sample genotypes are available at the European Genome-Phenome Archive with accession ID EGAS00000000109).</p> <p>probes_passing_QC.txt: List of probes passing quality control; probe sequences mapping to a unique genomic locus, and probe sequences not containing common genomic variation (minor allele frequency >1%), n=29,002. Column names are Array Address ID (probeID), Ensembl ID (ensembl), Gene ID (gene), and Illumina probe ID (ilmn). </p>
Membrane Fluctuation Model to Understand the Effect of the Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback
<p>Data for all the plots from original paper "Membrane Fluctuation Model to Understand the Effect of the Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback".</p>
Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors
ClinicalTrials.gov study NCT02100891. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety Study of Liver Natural Killer Cell Therapy for Hepatoma Liver Transplantation
ClinicalTrials.gov study NCT01147380. IPD Sharing: NO. Countries: 1. Publications: 1.
Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19
ClinicalTrials.gov study NCT04365101. IPD Sharing: NO. Countries: 1. Publications: 1.
Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia
ClinicalTrials.gov study NCT01904136. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Penostatin, Rituximab and Ontak and Allogeneic Natural Killer (NK) Cells for Refractory Lymphoid Malignancies
ClinicalTrials.gov study NCT01181258. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney Cancer
ClinicalTrials.gov study NCT00328861. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of CS1001 in Subjects With Relapsed or Refractory Extranodal Natural Killer/ T Cell Lymphoma(ENKTL)
ClinicalTrials.gov study NCT03595657. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Natural Killer (NK) Cell Transplantation for AML
ClinicalTrials.gov study NCT00187096. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Haploidentical Natural Killer Cells to Treat Refractory or Relapsed Acute Myelogenous Leukemia (AML)
ClinicalTrials.gov study NCT01106950. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Investigate Use of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Relapsed/Refractory Acute Myeloid Leukemia
ClinicalTrials.gov study NCT05712278. IPD Sharing: YES. Countries: 1. Publications: 0.
Datasets for the study "A Pan-Cancer Single Cell Panorama of Human Natural Killer Cells"
<p>File "comb_CD56_CD16_NK.h5ad" contains processed expression data and raw count data used in most part of the paper and annotations such as "meta_tissue_in_paper" and "cellType".</p><p>File "comb_CD56_CD16_NK_blood.h5ad" contains processed expression data used in the analysis of circulating NK cells and annotations such as "meta_tissue" and "cellType".</p><p>File "Integrated_CD16_NK cells.h5ad" contains processed expression data of CD56dimCD16hi NK cells used in most part of the paper and annotations such as "meta_tissue_in_paper" and "cellType".</p><p>File "Integrated_CD56_NK cells.h5ad" contains processed expression data of CD56brightCD16lo NK cells used in most part of the paper and annotations such as "meta_tissue_in_paper" and "cellType".</p>
Expanded Natural Killer (NK) Cells for Multiple Myeloma Study
ClinicalTrials.gov study NCT01040026. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Salvage Therapy With Chemotherapy and Natural Killer Cells in Relapsed/Refractory Paediatric T Cell Lymphoblastic Leukaemia and Lymphoma
ClinicalTrials.gov study NCT01944982. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase I Study of Umbilical Cord Blood Natural Killer (NK) Cell Therapy for Children With High-risk, R/R Neuroblastoma.
ClinicalTrials.gov study NCT06631391. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
ClinicalTrials.gov study NCT01916798. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Adoptive Immunotherapy of High Risk Acute Myeloblastic Leukemia Patients Using Haploidentical Kir Ligand-mismatched Natural Killer Cells
ClinicalTrials.gov study NCT00799799. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.