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552 results for “nitric oxide”

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zenodo44/100

Nitric oxide (NO) data set (60--160 km) from SCIAMACHY mesosphere--lower thermosphere limb scans

Overview Contains the nitric oxide (NO) number densities (in cm-3) from 60 km to 160 km retrieved from SCIAMACHY mesosphere--lower thermosphere (MLT, 50--150 km) limb scans. SCIAMACHY is a UV-visible-near-infrared spectrometer which flies on ESA's Envisat and was operational from 08/2002 to 04/2012 (see Burrows et al., 1995 and Bovensmann et al., 1999 and references therein). The Mesosphere--Lower Thermosphere (MLT) measurement mode was carried out from 07/2008 until the end of the mission for one day every 15 days. This data set comprises 84 days of SCIAMACHY MLT NO measurements, each containing about 15 orbits. The NO retrieval was carried out at the Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany, and is described in Bender et al., 2013. We used the SCIAMACHY geo-located atmospheric spectra (SCI_NL__1P) version 8.02 provided by ESA via their data browser at https://earth.esa.int/web/guest/data-access/browse-data-products. The spectra were calibrated with ESA's `SciaL1C` command line tool available for download at https://earth.esa.int/web/guest/software-tools/content/-/article/scial1c-command-line-tool-4073. The SCIAMACHY NO data were compared to the results from ACE-FTS, MIPAS, and SMR in Bender et al., 2015, showing that all agree within the respective measurement uncertainties. Acknowledgements The development of the retrieval was funded by the Helmholtz-society under the grant number VH-NG-624. The SCIAMACHY project, which was initiated by Professor Burrows in 1984, was funded by the German Aerospace  Agency (DLR), the Netherlands Space Office NSO, formerly NIVR, and the Belgium ministry responsible for space.  ESA funded the Envisat project. Professor Burrows of University of Bremen is the Principal Investigator. He and his  research team comprising his colleagues in Bremen and international scientific collaborators led the scientific  support and development of SCIAMACHY and the scientific exploitation of its  data products. The SCIAMACHY instrument is developed by an industrial team headed by companies now known as Airbus SD on the German side and by Dutch Space on the Dutch side and included Belgium companies. The instrument and algorithm development is supported by the activities of the SCIAMACHY Science Advisory Group (SSAG), a team of scientists from various  international institutions: University of  Bremen (D), SRON (NL), SAO (USA), IASB (B), MPI Chemistry Mainz (D), KNMI (NL),  University of Heidelberg (D), IMGA (I), CNRS-LPMA (F). Operational data processing is being performed by ESA and DLR-DFD within the ENVISAT ground  segment. Support with respect to mission planning and operations is given by  the SCIAMACHY Operations Support Team (SOST). The relevant work at the University of Bremen is funded by the University and State of Bremen.

opencc-by-sa-4.0Jun 2017View details →

zenodo44/100

Nitric oxide (NO) data set (60--160 km) from SCIAMACHY nominal limb scans

Overview Contains the nitric oxide (NO) number densities (in cm-3) from 60 km to 160 km retrieved from SCIAMACHY nominal (~0--90 km) limb scans. SCIAMACHY is a UV-visible-near-infrared spectrometer which flies on ESA's Envisat and was operational from 08/2002 to 04/2012 (see Burrows et al., 1995 and Bovensmann et al., 1999 and references therein). The nominal limb mode was carried out daily (apart from outages and a few days dedicated to other measurement modes) from 08/2002 until the end of the mission. The limb scans were performed from ground to about 90 km tangent altitude, and the retrieval was performed on a 2.5° x 2 km latitude--altitude grid from 90°S--90°N and from 60 km--160 km. This data set comprises all SCIAMACHY nominal NO measurements sorted by date and year, each day comprised about 15 orbits. See the accompanying README for the dimension and variable descriptions. The NO retrieval was carried out at the Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany, and is described in Bender et al., 2017. It is adapted from the MLT NO retrieval described in Bender et al., 2013. We used the SCIAMACHY geo-located atmospheric spectra (SCI_NL__1P) version 8.02 provided by ESA via their data browser at https://earth.esa.int/web/guest/data-access/browse-data-products. The spectra were calibrated with ESA's `SciaL1C` command line tool available for download at https://earth.esa.int/web/guest/software-tools/content/-/article/scial1c-command-line-tool-4073. The SCIAMACHY MLT NO data were previously compared to the results from ACE-FTS, MIPAS, and SMR in Bender et al., 2015, showing that all agree within the respective measurement uncertainties. This nominal data set here was not yet validated with other measurements but compares well to the SCIAMACHY MLT NO measurements below 90 km. Acknowledgements The development of the retrieval was funded by the Helmholtz-society under the grant number VH-NG-624. The SCIAMACHY project, which was initiated by Professor Burrows in 1984, was funded by the German Aerospace Agency (DLR), the Netherlands Space Office NSO, formerly NIVR, and the Belgium ministry responsible for space. ESA funded the Envisat project. Professor Burrows of University of Bremen is the Principal Investigator. He and his research team comprising his colleagues in Bremen and international scientific collaborators led the scientific support and development of SCIAMACHY and the scientific exploitation of its data products. The SCIAMACHY instrument is developed by an industrial team headed by companies now known as Airbus SD on the German side and by Dutch Space on the Dutch side and included Belgium companies. The instrument and algorithm development is supported by the activities of the SCIAMACHY Science Advisory Group (SSAG), a team of scientists from various international institutions: University of Bremen (D), SRON (NL), SAO (USA), IASB (B), MPI Chemistry Mainz (D), KNMI (NL), University of Heidelberg (D), IMGA (I), CNRS-LPMA (F). Operational data processing is being performed by ESA and DLR-DFD within the ENVISAT ground segment. Support with respect to mission planning and operations is given by the SCIAMACHY Operations Support Team (SOST). The relevant work at the University of Bremen is funded by the University and State of Bremen.

opencc-by-sa-4.0Jun 2017View details →

zenodo40/100

Data related to "Emissions of atmospherically reactive gases nitrous acid and nitric oxide from arctic permafrost peatlands"

The data file contains the individual (each replicate) values of the soil variables and gas fluxes obtained from the study. It contains data shown in the both main text and supplementary files.

opencc-by-4.0Jan 2022View details →

zenodo40/100

Dissolved nitric oxide concentrations and other parameters measured in the Lower Elbe Estuary and the Hamburg Port Area during the RV Ludwig Prandtl Cruise in July 2021

The Elbe River's high nutrient loads and phytoplankton biomass contribute to the complex nutrient turnover processes in the Elbe Estuary, especially within the Port of Hamburg. This campaign aims to investigate the nitrogen turnover processes and nitrous oxide and nitric oxide production in the Elbe Estuary and the Port of Hamburg from 26 to 29 July 2021. Surface water samples were collected on board the RV Ludwig Prandtl using a FerryBox flow-through system. The system, which draws water from approximately 2 meters below the surface through a membrane pump, continuously measured in situ biogeochemical parameters, including dissolved oxygen, pH, salinity, and water temperature. Discrete water samples were collected every 20 minutes for nutrient analysis, chlorophyll a, and dissolved nitric oxide (NO) following established collection, preservation, and storage protocols (Schulz et al., 2022; Norbisrath et al., 2022). Furthermore, nitrous oxide (N2O) concentrations were measured continuously using laser-based off-axis integrated cavity output spectroscopy (OA_ICOS) coupled with a water/gas equilibrator. Additionally, wind speeds at a height of 10 meters were recorded using a MaxiMet GMX600 weather station. Triplicate NO samples were analyzed within 20 minutes of collection, adhering to the method outlined by Lutterbeck and Bange (2015).

opencc-by-4.0Jun 2024View details →

zenodo40/100

Hydroxyurea inhibits proliferation and stimulates apoptosis through inducible nitric oxide synthase in erythroid cells.

<a name="_Hlk164856369"></a>Hydroxyurea (HU) arrests cells in S-phase through the inhibition of ribonucleotide reductase and DNA synthesis, which is contributed significantly by the release of nitric oxide (NO). We investigated the mediation of inducible NO synthase (NOS2) in HU cytostatic effects, <a name="_Hlk165036602"></a>using in vitro shRNA-induced knock-down of NOS2 or specific NOS2 inhibitor (1400W), and supported by Nos2 knockout mice (Nos2-/-) to observe ex vivo murine erythroid progenitors (mERP).<a name="_Hlk165036694"></a>As a long-term effect, HU increased NOS2 expression in human erythroleukemic HEL92.1.7 cells (via NFκB signaling) and mERP. As a short-term result, HU increased the activity of purified and HEL92.1.7 cell-derived NOS2, as confirmed by NO / citrulline production and in silico molecular docking via hydrogen bonds. Molecular dynamic simulation showed a slight decrease in NOS2 receptor rigidity upon HU binding, confirming the stability of HU at the active site of the NOS2 receptor. Both 1400W and shRNA prevented the in vitro reduction of proliferation and induction of apoptosis of HEL92.1.7 cells by HU. Thus, shRNA blocked preferentially early apoptosis and only shRNA overcame HU-induced S-phase arrest of HEL92.1.7 cells. Both 1400W and Nos2 knockout prevented the in vivo decrease in proliferation and induction of apoptosis of mERP by HU from wild-type and Nos2-/- mice, respectively. Therefore, HU increased NOS2 activity and expression via NFκB signaling. This study demonstrated the NOS2 dependance in the HU inhibition of proliferation and stimulation of apoptosis of erythroid cells.

opencc-by-4.0Jul 2024View details →

dryad40/100

Data from: Differential pulse sensitivity of nitric and nitrous oxide emissions to temperature, carbon, and nitrogen following wetting of desert soils

Open the record for dataset details and reuse information.

publicNov 2025View details →

dryad40/100

Nitric oxide is not responsible for initial sensory-induced neurovascular coupling response in the barrel cortex of lightly anaesthetised mice

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publicJun 2025View details →

dryad36/100

δ15N of nitric oxide produced under aerobic or anaerobic conditions from seven soils and their associated N isotope fractionations

Measuring the nitrogen isotope compositions (δ15N) of nitric oxide (NO) from different sources helps to quantify the relative contributions of atmospheric NOx. Soil is one of the most important sources of atmospheric NOx, but only limited measurements on the δ15N of soil emitted NO exist, hampering our ability to partition sources to air pollution. Here we conducted soil incubations to measure the δ15N-NO under defined aerobic or anaerobic conditions, favoring either nitrification or denitrification. Soils were collected from seven sites spanning three ecosystems in northern China (two agricultural, two forest, and three grassland sites). We found that the δ15N-NO and their associated N isotope fractionations were significant different between anaerobic and aerobic conditions in seven soils. Under aerobic condition, the δ15N-NO ranged from -62‰ to -50‰ (averaged -56 ± 4‰), being significantly more negative (by 23‰) than those under anaerobic condition (-45‰ to -23‰, averaged -33 ± 7‰). The apparent N isotope fractionation for NO production under aerobic condition (15εaerobic = 61 ± 3‰) was significantly higher (by 26‰) than under anaerobic condition (15εanaerobic = 35 ± 6‰), with a small variability among ecosystem types. Our study demonstrates that the δ15N-NO from different soils are very different from fuel combustions (mainly from 0 to +20‰), supporting that measuring 15N is a useful tool to partition the contributions of soil NO to atmospheric NOx. Our results also imply δ15N-NO produced by nitrification and denitrification distinctly different, as these two processes are dominant processes producing NO under aerobic and anaerobic conditions, respectively.

opencc-zeroAug 2020View details →

zenodo36/100

Diffraction images for crystals of the Roseobacter denitrificans nitric oxide reductase (PDB code 4XYD)

X-ray diffraction images corresponding to the dataset from which pdb entry 4XYD was refined. Data was collected at the ESRF. The paper describing the structure is: Structure of the membrane-intrinsic nitric oxide reductase from Roseobacter denitrificans Allister Crow, Yuji Matsuda, Hiroyuki Arata, and Arthur Oubrie doi 10.1021/acs.biochem.6b00332

opencc-zeroAug 2015View details →

zenodo36/100

Research data supporting "Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for glaucoma"

Research data supporting the paper above published at DOI: 10.1002/adma.201604932

opencc-by-4.0Feb 2017View details →

dryad36/100

Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction

Cell therapy by autologous mesenchymal stem cells (MSCs) is a clinically acceptable strategy for treating various diseases. Unfortunately, the therapeutic efficacy is largely affected by the low quality of MSCs collected from patients. Herein, we showed that the gene expression of MSCs from patients with diabetes was differentially regulated compared to that of MSCs from healthy controls. Then, MSCs were genetically engineered to catalyse an NO prodrug to release NO intracellularly. Compared to extracellular NO conversion, intracellular NO delivery effectively prolonged survival and enhanced the paracrine function of MSCs, as demonstrated by in vitro and in vivo assays. The enhanced therapeutic efficacy of engineered MSCs combined with intracellular NO delivery was further confirmed in mouse and rat models of myocardial infarction, and a clinically relevant cell administration paradigm through secondary thoracotomy has been attempted.

opencc-zeroOct 2023View details →

dryad36/100

A synthesis of nitric oxide emissions across global fertilized croplands from crop-specific emission factors

Nitrogen (N)-fertilizer application to agricultural soils results in substantial emissions of nitric oxide (NO), a key substance in tropospheric chemistry involved in climate forcing and air pollution. However, estimates of global cropland NO emissions remain uncertain due to a lack of information on direct NO emission factors (EFds) of applied N for variours cropping systems at seasonal or annual scales. Here we quantified the crop-specific seasonal and annual-scale NO EFds through synthesizing 1094 measurements from 125 field-based studies worldwide. The global mean crop-specific seasonal EFd was 0.53%, with the highest for vegetables (0.75%). Among cereal crops, the EFd of maize (0.45%) or wheat (0.47%) was about three-times higher than for rice (0.12%). At annual scale, the mean EFd across all cropping systems was 0.58%, with tea plantations having the highest (1.54%). For other cropping systems, the annual-scale EFds ranged from 0.02% to 1.07%. Besides crop type, also soil organic carbon, total N and pH as well as N fertilizer type were the main factors explaining the variations of NO EFds. Based on obtained specific EFds for each crop type, we estimated that NO emissions due to the use of synthetic fertilizers from global croplands are about 0.42–0.62 Tg N yr−1. Our budgets are relatively lower if compared to estimates derived by the use of IPCC defaults for NO emissions (0.72–1.66 Tg N yr−1) or reported elsewhere (0.67–1.04 Tg N yr−1). In our estimates, cash crops (vegetable, tea and orchard), which cover only 9% of the world cropland area, contributed about 31% to total NO emissions from global fertilized croplands. Overall, our meta-analysis provides improved crop-specific NO EFds reflecting current stage of knowledge. The work also highlights the relative importance of cash crop production as sources for atmospheric NO, i.e., agricultural systems on which mitigation efforts may focus.

opencc-zeroApr 2022View details →

dryad36/100

DNA Methyltransferase regulates nitric oxide homeostasis and virulence in a chronically adapted Pseudomonas aeruginosa strain

Opportunistic pathogens such as Pseudomonas aeruginosa adapt their genomes rapidly during chronic infections. Understanding their epigenetic regulation may provide biomarkers for diagnosis and reveal novel regulatory mechanisms. We performed single-molecule real-time sequencing (SMRT-seq) to characterize the methylome of a chronically adapted P. aeruginosa clinical strain TBCF10839. Two N6-methyl-adenine (6mA) methylation recognition motifs (RCCANNNNNNNTGAR and TRGANNNNNNTGC) were identified and predicted as new type I methylation sites using REBASE analysis. We confirmed that motif TRGANNNNNNTGCwas methylated by MTase M.PaeTBCFII, according to methylation sensitivity assays in vivo and vitro. Transcriptomic analysis showed that ΔM.PaeTBCFII knockout mutant significantly downregulated nitric oxide reductase (NOR) regulating and coding gene expression such as nosR and norB, which contain methylated motifs in their promoters or coding regions. ΔM.PaeTBCFII exhibited reduced intercellular survival capacity in NO-producing RAW 264.7 macrophages and attenuated virulence in Galleria mellonella infection model; the complemented strain recovered these defective phenotypes. Further phylogenetic analysis demonstrated that homologs of M.PaeTBCFII occur frequently in P. aeruginosa sp as well as other bacterial species. Our work therefore provided new insights on the relationship between DNA methylation, NO detoxification, and bacterial virulence, laying a foundation for further exploring the molecular mechanism of DNA methyltransferase in regulating the pathogenicity of P. aeruginosa.

opencc-zeroAug 2022View details →

zenodo36/100

INHIBITION OF NITRIC OXIDE SYNTHESIS PROMOTES INCREASED MORTALITY DESPITE REDUCTION OF PARASITEMIA IN Plasmodium berghei-INFECTED MICE

Backgrounds: Nitric oxide (NO) is an important mediator molecule in inflammatory processes, but its role in the pathophysiology of malaria is still uncertain. Methods: To investigate the NO synthesis inhibition on the oxidative changes induced by Plasmodium berghei infection in mice, malaria was induced in 150 animals, of which 75 animals were treated with NO inhibitor L-NAME; the remaining are sham controls. All animals underwent euthanasia after 1, 5, 10, 15 or 20 days after the infection for the collection of lungs, brain, and blood. Parasitemia was determined and the survival of the animals evaluated. Tissue samples were assayed for nitrites and nitrates (NN), thiobarbituric acid reactive substances (TBARS), and total Trolox equivalent antioxidant capacity (TEAC). A histopathological study was performed. Results: Mortality rates in the L-NAME were always higher in relation to the controls. In brains, NN was lower in groups L-NAME. Parasitemia and its progression rate were greater in control groups. From the 5th day of infection, mice treated with L-NAME showed cerebral edema and interstitial pneumonia of greater intensity than controls. Conclusions: Anti-inflammatory and hemodynamic effects of NO surpasses its pro-oxidant role in murine malaria. Backgrounds: Nitric oxide (NO) is an important mediator molecule in inflammatory processes, but its role in the pathophysiology of malaria is still uncertain. Methods: To investigate the NO synthesis inhibition on the oxidative changes induced by Plasmodium berghei infection in mice, malaria was induced in 150 animals, of which 75 animals were treated with NO inhibitor L-NAME; the remaining are sham controls. All animals underwent euthanasia after 1, 5, 10, 15 or 20 days after the infection for the collection of lungs, brain, and blood. Parasitemia was determined and the survival of the animals evaluated. Tissue samples were assayed for nitrites and nitrates (NN), thiobarbituric acid reactive substances (TBARS), and total Trolox equivalent antioxidant capacity (TEAC). A histopathological study was performed. Results: Mortality rates in the L-NAME were always higher in relation to the controls. In brains, NN was lower in groups L-NAME. Parasitemia and its progression rate were greater in control groups. From the 5th day of infection, mice treated with L-NAME showed cerebral edema and interstitial pneumonia of greater intensity than controls. Conclusions: Anti-inflammatory and hemodynamic effects of NO surpasses its pro-oxidant role in murine malaria.

opencc-by-4.0Nov 2017View details →

zenodo36/100

Effects of nitrate and ammonium on assimilation of nitric oxide by Heterosigma akashiwo

This data set includes 15-NO uptake rates, gene expression of NR, GOGAT and GS, and nitrate reductase activity for the raphidophyte Heterosigma akashiwo. For details, see Healey, E.M., Flood, S., Bock, P.K., Fulwieler, R.W., York, J.K. and Coyne, K.J. (2023) Effects of nitrate and ammonium on assimilation of nitric oxide by Heterosigma akashiwo. Sci Rep 13, 621. DOI: 10.1038/s41598-023-27692-3.  Funding source: US National Oceanic and Atmospheric Association (NOAA) National Centers for Coastal Ocean Science (NCCOS) grant number NA18NOS4780165; ECOHAB 2017: The role of nitric oxide in promoting Heterosigma blooms.

opencc-by-4.0Apr 2024View details →

zenodo36/100

Effects of Energetic Electron and Proton Precipitations on Thermospheric Nitric Oxide Cooling during shock-led Interplanetary Coronal Mass Ejections

Satellite measurements have revealed significant enhancement of 5.3-µm nitric oxide (NO) emission during shock-led interplanetary coronal mass ejections (ICMEs). Great discrepancies in modeled neutral density occur during these events, and may be attributed to the abnormally high NO cooling. Meanwhile, the relative significance of protons, soft electrons, and keV-electrons to NO emission is yet to be well determined. The goal of this study is to identify the contribution of electron and proton precipitations to the thermospheric NO cooling by using the Defense Meteorological Satellite Program (DMSP) data. The observed energetic electrons and protons (0.1–30.2 keV) during 36 shock-led ICME events in 2002–2010 are binned into geomagnetic grids to provide statistical distributions of the particle precipitation for polar regions. The distributions are incorporated into the Global Ionosphere-Thermosphere Model. The results show that electrons play a dominant role to NO cooling, but protons are also important and contribute to up to a quarter of NO cooling by electrons and ions combined. NO cooling enhancement during the events is proportional to the level of energy flux and is dominated by the electrons in the energy band of 1.4–3.1 keV. Both total electron content (TEC) and NO cooling enhance at the source regions, but they have different lifetime and correlation with the particle precipitations. Generally, NO cooling and TEC enhancements have a positive correlation with the precipitating energy. Cross correlation shows that particle precipitations have more direct and instantaneous impact on TEC while it takes longer for the atmosphere to heat up for cooling to proceed.

opencc-by-4.0Sep 2019View details →

zenodo36/100

Anammox bacteria originally used nitric oxide as electron accepter

Anaerobic ammonium oxidation (anammox) bacteria has been known to oxidize ammonium with nitrite as the terminal electron acceptor. Recently, however, nitric oxide (NO)-dependent anammox has been shown in Candidatus (Ca.) Kuenenia stuttgartiensis with first complete genome and it is hypothesized that NO-dependent anammox bacteria existed on early Earth. Here we report second complete genome of anammox bacteria, Ca. Brocadia pituitae, from metagenome of anammox bacterial community (ABC). Comparative genomics of B. pituitae, K. stuttgartiensis and 6 other anammox bacteria with nearly complete genomes revealed that their core genome structure comprises syntenic 1,152 orthologous groups. Both copper-containing (NirK) and cd1 (NirS) nitrite reductases which are absent in B. pitutitae were not included in the core although Ca. Brocadia sp. UTMX2 and Ca. B. caroliniensis possess nirK gene. Indeed, IS element is inserted adjacent to the nirK gene in Ca. Jettenia caeni genome and also phylogenetic analysis revealed that the origin of nitrite reductases is derived from multiple lineages. Thus, it is clear that the nirK and nirS genes of anammox bacteria within family Brocadiaceae were acquired by horizontal gene transfer. ABC fed with nitrite and ammonium shows anammox activity but it disappears when the biomass granules are dispersed by agitation. Also, because ABC can oxidize ammonium with NO like K. stuttgartiensis, other nitrite reductase holders in ABC are deemed to supply NO to B. pituitae. Our results support the previous hypothesis that anammox bacteria originally used NO as electron accepter.

opencc-by-4.0May 2020View details →

zenodo36/100

PRISMA flowchart for Article "Nitric oxide and tuberculosis: Systematic Review and Meta-Analysis"

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opencc-by-4.0Aug 2024View details →

zenodo36/100

Supplementary files for "Data-driven estimation of nitric oxide emissions from global soils based on dominant vegetation covers"

In-situ observations collected from publications, data-driven model codes, DNDC simulation files, and the supporting data for all figures of this study are uploaded. In-situ observations included 1,356 observations of soil nitric oxide (NO) emissions from 192 sites, including 1,032 for cropland soils from 70 sites, 114 for grassland soils from 36 sites, and 208 for forest soils from 86 sites. Data-driven models provided three machine learning methods, including random forest (RF), generalized boosted regression model (GBM), and radial basis function (RBF). The DNDC simulation files included simulation files of 51 selected sites.

opencc-by-4.0Jun 2023View details →

ClinicalTrials.gov36/100

Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1

ClinicalTrials.gov study NCT04770155. IPD Sharing: YES. Countries: 1. Publications: 5.

controlledIPD-YESFeb 2026View details →

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Last verified 2026-04-30Open record

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Last verified 2026-04-29Open record

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Last verified 2026-04-29Open record