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189 results for “nociception”
Source Data for Published Study "Are changes in nociceptive withdrawal reflex magnitude a viable central sensitization proxy? Implications of a replication attempt"
<p>Upload version NWR_v01_20230409</p> <p>Authors: Alexandros Guekos, Alince Catrine Grata, Michèle Hubli, Martin Schubert, and Petra Schweinhardt</p> <p>The present data was collected from August to October 2019 as part of a replication attempt of a previously published study (Ellrich, J., and R-D. Treede. "Convergence of nociceptive and non-nociceptive inputs onto spinal reflex pathways to the tibialis anterior muscle in humans." Acta physiologica scandinavica 163.4 (1998): 391-401, https://doi.org/10.1046/j.1365-201X.1998.t01-1-00392.x). </p> <p>The results of the replication study have been published under open access (Guekos, A., et al. "Are changes in nociceptive withdrawal reflex magnitude a viable central sensitization proxy? Implications of a replication attempt" Clinical Neurophysiology 145 (2023): 139-150, https://doi.org/10.1016/j.clinph.2022.09.011).</p> <p>Details of the paradigm, the experimental setup, and the analysis can be found there.</p> <p>In brief, 16 healthy adults (8 men and 8 women) underwent a single experimental session during which a tonic heat stimulus was applied on one leg to the foot sole and on the other to the calf muscle. Both legs were tested consecutively in pseudorandom order. Concurrently, subjects received transcutaneous electrical stimuli to elicit the nociceptive withdrawal reflex (NWR). The muscle responses were recorded via surface electromyography (sEMG) from the biceps femoris (BF), rectus femoris (RF), and tibialis anterior (TA).</p> <p>The protocol consisisted of eight blocks per leg. During the first two blocks no temperature stimulation was applied. These two blocks served to identify the NWR threshold at the BF. For threshold determination, a single ascending staircase with either single electrical stimulations or triplets (at 2Hz) were used. From the triplets, only the muscle response to the third stimulation was analysed. The higher of the two obtained currents was used as the threshold. The following six blocks used six different temperatures (one per block) of 32, 36, 39, 42, 45 and 46 centigrade. During each block eight transcutaneous electrical stimuli were applied, either to the medial plantar nerve (MP) on the foot sole or to the retromalleolar pathway of the sural nerve (SU). The stimulations increased from -4 mA w.r.t. threshold to 200% threhold. Participants verbally rated perceived pain for every stimulation during these six blocks.</p> <p>Every electrical stimulation consisted of a train of five rectangular stimuli of 1 ms duration delivered at 200 Hz. Muscle responses were recorded from 120 pre- to 380 ms post-stimulation. The recorded sEMG signals were sampled at 48 kHz and downsampled to 6 kHz, rectified, band-pass filtered from 10 Hz to 500 Hz and amplified up to 125 times. Between 120 ms pre- and 380 ms post-stimulation, traces for all applied stimulations were automatically saved into separate txt files.</p> <p>Please consult the README.txt file for details on the structure of the uploaded data and for information w.r.t. potential instances of incompleteness or unusability.</p> <p>The study was funded by the Swiss National Science Foundation as part of a grant to PS (grant number 320030_179191/1).</p>
Data for: Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila
<p>Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between potentially harmful and innocuous stimuli is broadly important for organismal survival. Moreover, disruptions in the capacity to differentiate between noxious and innocuous stimuli can result in neuropathic pain. <em>Drosophila</em> larval Class III (CIII) neurons are peripheral noxious cold nociceptors and innocuous touch mechanosensors; high levels of activation drive cold-evoked contraction (CT) behavior, while low levels of activation result in a suite of touch-associated behaviors. However, it is unknown what molecular factors underlie CIII multimodality. Here, we show that the TMEM16/anoctamins <em>subdued</em> and <em>white walker</em> (<em>wwk</em>; <em>CG15270</em>) are required for cold-evoked CT, but not for touch-associated behavior, indicating a conserved role for anoctamins in nociception. We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of <em>ncc69</em>-a fly homologue of <em>NKCC1</em>-results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making <em>Drosophila</em> CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain</p>
Comparison of the Skin Conductance Algesimeter and the Nociception Level Index in the Paediatric Population. An Observational Study.
ClinicalTrials.gov study NCT05998564. IPD Sharing: UNDECIDED. Countries: 1. Publications: 20.
Clinical Trial of the invisaRED® IR REHAB Device When Used as an Adjunctive Therapy for Nociceptive Musculoskeletal Pain
ClinicalTrials.gov study NCT06393088. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
ClinicalTrials.gov study NCT04050384. IPD Sharing: NO. Countries: 1. Publications: 4.
Meningeal regulatory T cells inhibit nociception in female mice
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Data computational model parameters of nociceptive medullary dorsal horn projection neuron from: Opposite regulation of medullary pain-related projection neuron excitability in acute and chronic pain
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Data for: Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila
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Functional representation of trigeminal nociceptive input in the human periaqueductal gray
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The nociceptive withdrawal reflex during spinal analgesia in pigs undergoing veno-arterial extracorporeal membrane oxygenation: a prospective observational study.
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Pain Protocol: Nociception Coma Scale-Revised With Personalized Stimulus
ClinicalTrials.gov study NCT06012357. IPD Sharing: YES. Countries: 1. Publications: 1.
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
ClinicalTrials.gov study NCT06291363. IPD Sharing: NO. Countries: 1. Publications: 15.
Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Crani
ClinicalTrials.gov study NCT05763836. IPD Sharing: YES. Countries: 1. Publications: 18.
Characterization of the Temporal Profile of the Anti-nociceptive Effect of Ketamine Bolus Measured With ANI
ClinicalTrials.gov study NCT06344858. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Precision Medicine for Nociception, Sngception and Proprioception.
ClinicalTrials.gov study NCT06161038. IPD Sharing: NO. Countries: 1. Publications: 21.
Evaluation of Nociceptive Processing in the Cervical Region
ClinicalTrials.gov study NCT04242576. IPD Sharing: NO. Countries: 1. Publications: 10.
Fentanyl Ultra Low Doses Effects on the Nociceptive Threshold
ClinicalTrials.gov study NCT00454259. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Ability of Changes in Analgesia Nociception Index to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
ClinicalTrials.gov study NCT04223414. IPD Sharing: NO. Countries: 1. Publications: 1.
Locating Nociceptive Stimuli on Digital Body Chart
ClinicalTrials.gov study NCT03463109. IPD Sharing: YES. Countries: 1. Publications: 2.
A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia
ClinicalTrials.gov study NCT00965601. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.