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159 results for “nucleus accumbens”
Subset of nucleosomal DNA sequences from mouse brain nucleus accumbens tissue (GEO dataset GSE54263)
<p>This dataset contains a subset of nucleosomal DNA sequences of +1 nucleosomes from mouse brain nucleus accumbens cells (NAC) used to analyze nucleosome positioning sequence (NPS) patterns in <a href="https://doi.org/10.1371/journal.pcbi.1007365">Pranckeviciene, Erinija and Hosid, Sergey and Liang, Nathan and Ioshikhes, Ilya (2020). Nucleosome positioning sequence patterns as packing or regulatory. In PLoS computational biology, 16 (1), pp. e1007365.</a></p> <ul> <li>controlm.fa.gz contains sequences of <strong>control</strong> mice (GSE54263 subset Con_H3 GSM1311267)</li> <li> resilientm.fa.gz contains sequences of mice <strong>resilient to social stress</strong> (GSE54263 subset Res_H3 GSM1311268)</li> <li> susceptiblem.fa.gz contains sequences of<strong> </strong>mice <strong>susceptible to social stress</strong> (GSE54263 subset Sus_H3 GSM1311269)</li> </ul> <p>This dataset originates from the GEO accession GSE54263 data from <a href="https://www.nature.com/articles/nm.3939">Sun H, Damez-Werno DM, Scobie KN, Shao NY et al. ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior. <em>Nat Med</em> 2015 Oct;21(10):1146-53.</a></p>
Data set for "Dopamine dynamics in nucleus accumbens across reward-based learning of goal-directed whisker-to-lick sensorimotor transformations in mice"
<p>Data set for: Huang J, Crochet S, Sandi C, Petersen CCH (2024) Dopamine dynamics in nucleus accumbens across reward-based learning of goal-directed whisker-to-lick sensorimotor transformations in mice. Heliyon 10: e37831. https://doi.org/10.1016/j.heliyon.2024.e37831<br><br></p> <p>There are 2 files in this upload:</p> <p>1. The file named "2024_Huang_Heliyon.pdf" is the Open Access pdf of the online publication in Heliyon.</p> <p>2. The file named "Huang_data_code.zip" (~6 GB) is a zipped version of a folder "Huang_data_code" (~6 GB), which contains the data analysed in the study along with the Matlab codes used to generate the published figures. To access the data and codes, first unzip the file. You need to install the Matlab 'Signal Processing' and 'Curve Fitting' Toolboxes. In Matlab, add the path of the folder "Huang_data_code" and all subfolders. The main folder unzips into three subfolders: i) "Huang_dLight_data_code", which contains the dLight data; ii) "Huang_muscimol_data_code", which contains the behavioral data for muscimol inactivation experiments; and iii) "Huang_singletrial_example", which contains the data for the single trial example data shown in Figure 1C (note for this to run you first need to load the data file "JH056_190308_WD.mat"). In the folder "Huang_dLight_data_code", you can also find a "DataViewer" to visualise the data trial-by-trial, which you can run by executing "DataViewer.mlapp" directly from the subfolder "Huang_dLight_data_code" after loading the data "Huang_database.mat".</p>
Data from: No evidence for sex differences in the electrophysiological properties and excitatory synaptic input onto nucleus accumbens shell medium spiny neurons
<p>Sex differences exist in how the brain regulates motivated behavior and reward, both in normal and pathological contexts. Investigations into the underlying neural mechanisms have targeted the striatal brain regions, including the dorsal striatum and nucleus accumbens core and shell. These investigations yield accumulating evidence of sexually different electrophysiological properties, excitatory synaptic input, and sensitivity to neuromodulator/hormone action in select striatal regions both before and after puberty. It is unknown whether the electrical properties of neurons in the nucleus accumbens shell differ by sex and whether sex differences in excitatory synaptic input are present before puberty. To test the hypothesis that these properties differ by sex, we performed whole-cell patch-clamp recordings on male and female medium spiny neurons (MSNs) in acute brain slices obtained from prepubertal rat nucleus accumbens shell. We analyzed passive and active electrophysiological properties, and miniature EPSCs (mEPSCs). No sex differences were detected; this includes those properties, such as intrinsic excitability, action potential after hyperpolarization, threshold, and mEPSC frequency, that have been found to differ by sex in other striatal regions and/or developmental periods. These findings indicate that, unlike other striatal brain regions, the electrophysiological properties of nucleus accumbens shell MSNs do not differ by sex. Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions.</p>
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
<p>In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus, CS) also gain incentive salience to promote drug seeking. The basolateral amygdala (BLA) is implicated in both US- and CS-mediated responses. Here, we show that two genetically distinct BLA neuronal types, expressing Rspo2 versus Ppp1r1b, respectively, project to the nucleus accumbens (NAc) and form monosynaptic connections with both dopamine D1 and D2 receptor-expressing neurons. While intra-NAc stimulation of Rspo2 or Ppp1r1b presynaptic terminals establishes intracranial self-stimulation (ICSS), only Ppp1r1b-stimulated mice exhibit cue-induced ICSS seeking. Furthermore, increasing versus decreasing the Ppp1r1b-to-NAc, but not Rspo2-to-NAc, subprojection increases versus decreases cue-induced cocaine seeking after cocaine withdrawal. Thus, while both BLA-to-NAc subprojections contribute to US-mediated responses, the Ppp1r1b subprojection selectively encodes CS-mediated reward and drug reinforcement. Such differential circuit representations may provide insights into precise understanding and manipulation of drug- versus cue-induced drug seeking and relapse.</p>
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
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Data from: No evidence for sex differences in the electrophysiological properties and excitatory synaptic input onto nucleus accumbens shell medium spiny neurons
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Neuron soma size and density measurements in male and female adult rat nucleus accumbens shell, nucleus accumbens core, and caudate-putamen disaggregated by sex and estrous cycle phase
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Cholinergic interneurons and dopamine in the nucleus accumbens
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Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens of Alcohol-Withdrawn Rats
<p>An alcohol withdrawal syndrome is a potentially life-threatening condition, which may occur when patients with alcohol use disorders have to undergo general anesthesia. Excitatory amino acids, such as glutamate, act as neurotransmitters and play a key role in alcohol withdrawal. We investigated the influence of isoflurane, sevoflurane, and desflurane anesthesia on the profile of excitatory and inhibitory amino acids in the Nucleus accumbens (NAcc) of alcohol-withdrawn rats (AWR).</p> <p>80 Wistar rats were randomized into two groups of 40, pair-fed with alcoholic or non-alcoholic nutrition. Nutrition was withdrawn and microdialysis trials were performed to measure the activity of amino acids in the NAcc. The withdrawal onset time was determined in a first trial with 20 rats. 60 rats then received isoflurane, sevoflurane, or desflurane anesthesia for three hours during withdrawal period, followed by one hour of elimination. Amino acid concentrations were obtained by chromatography. Quantification was done by integration and analysis of the area under the curve (AUC).</p>
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens of Alcohol-Withdrawn Rats
<p>An alcohol withdrawal syndrome is a potentially life-threatening condition, which may occur when patients with alcohol use disorders have to undergo general anesthesia. Excitatory amino acids, such as glutamate, act as neurotransmitters and play a key role in alcohol withdrawal. We investigated the influence of isoflurane, sevoflurane, and desflurane anesthesia on the profile of excitatory and inhibitory amino acids in the Nucleus accumbens (NAcc) of alcohol-withdrawn rats (AWR).</p> <p>80 Wistar rats were randomized into two groups of 40, pair-fed with alcoholic or non-alcoholic nutrition. Nutrition was withdrawn and microdialysis trials were performed to measure the activity of amino acids in the NAcc. The withdrawal onset time was determined in a first trial with 20 rats. 60 rats then received isoflurane, sevoflurane, or desflurane anesthesia for three hours during withdrawal period, followed by one hour of elimination. Amino acid concentrations were obtained by chromatography. Quantification was done by integration and analysis of the area under the curve (AUC).</p>
Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
<p>This dataset presents electrophysiological properties from whole-cell patch clamped nucleus accumbens core medium spiny neurons from male rats and female rats recorded in different estrous cycle phases. Excitatory synaptic input, action potential, and intrinsic properties are presented in an analyzed format, as well as the original electrophysiological recordings of each neuron. These data were originally presented across two different papers (Proaño et al., 2018, 2020) and further analyzed in an additional paper (Long et al., 2024), all of which are cited below. These data were key for establishing that nucleus accumbens neuron electrical function changed across the estrous cycle in response to its associated hormones, programming a phase-dependent sex difference in adulthood. This finding provided a new framework for understanding how biological sex and hormone cyclicity regulate the neurons implicated in motivated behaviors and related functions and disorders.</p>
Dataset: Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement.
<p>This dataset contains the data presented in the paper Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. (doi: 10.7554/eLife.39945 )</p>
Deep Brain Stimulation of Nucleus Accumbens for Chronic and Resistant Major Depressive Disorder
ClinicalTrials.gov study NCT01569711. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation of the Bilateral Nucleus Accumbens for Patients With Methadone Maintenance Treatment
ClinicalTrials.gov study NCT03952455. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction
ClinicalTrials.gov study NCT03347474. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation of the Nucleus Accumbens as a Novel Treatment in Severe Opioid Addiction
ClinicalTrials.gov study NCT01245075. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation of Nucleus Accumbens for Opioid Relapse Prevention
ClinicalTrials.gov study NCT03424616. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation of Nucleus Accumbens to Prevent Opiate Relapse
ClinicalTrials.gov study NCT01274988. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
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Full summary statistics of mixQTL for GTEx v8 Brain_Nucleus_accumbens_basal_ganglia
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.