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9 results for “olfactory cortex”
Characterizing Novel Olfactory Receptors Expressed in the Murine Renal Cortex: Supplemental Table S1
<p><strong>Ligand screening of Olfr90, Olfr461, Olfr558, Olfr1034, and Olfr1396.</strong> The complete screening results of all compounds tested on all 5 murine ORs. Compounds were tested at 0.5 mM unless otherwise specified. “+” indicates robust statistically signification activation, while “–” indicates no response. ORs listed in the Classification column are siblings of tested ORs. The term “general” is used for compounds in our library that are commonly used to screen ORs, and “biofluids” refers to compounds listed in the Human Metabolome Database which are detected in biofluids such as blood, urine, etc.</p> <p> </p> <p> </p>
Characterizing Novel Olfactory Receptors Expressed in the Murine Renal Cortex: Supplemental Table S2
<p><strong>Olfactory receptors selected for study. </strong>Olfactory receptors (ORs) selected for study based on mapped reads in at least 7 out of 8 murine renal cortex samples. Murine samples are listed as A - M. Samples A - G were fed high fat diet, while samples I - M were fed control diet. (mm10) FPKM counts for ORs selected for study based on the GRCm30/mm10 genome build using previously published OR coordinates. ORs are listed using the "Olfr" gene names, as well as the "CUFFOR" names as determined by Ibarra-Soria X et al. (mm9) FPKM counts for ORs selected for study based on the NCBI37/mm9 genome build using established coordinates. ORs listed in green were identified and cloned from kidney RNA previously.</p> <p> </p> <p>Data accessible at NCBI GEO database, accession number GSE117249<br> https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117249</p>
Data from: Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation
<p>Rodents depend on olfaction and touch to meet many of their fundamental needs. The joint significance of these sensory systems is underscored by an intricate coupling between sniffing and whisking. However, the impact of simultaneous olfactory and tactile inputs on sensory representations in the cortex remains elusive. To study these interactions, we recorded large populations of barrel cortex neurons using 2-photon calcium imaging in head-fixed mice during olfactory and tactile stimulation. We find that odors alter barrel cortex activity in at least two ways, first by enhancing whisking, and second by central cross-talk that persists after whisking is abolished by facial nerve sectioning. Odors can either enhance or suppress barrel cortex neuronal responses, and while odor identity can be decoded from population activity, it does not interfere with the tactile representation. Thus, barrel cortex represents olfactory information which, in the absence of learned associations, is coded independently of tactile information.</p>
Parallel processing by distinct classes of principal neurons in the olfactory cortex
<p>Understanding how distinct neuron types in a neural circuit process and propagate information is essential for understanding what the circuit does and how it does it. The olfactory (piriform, PCx) cortex contains two main types of principal neurons, semilunar (SL) and pyramidal (PYR) cells. SLs and PYRs have distinct morphologies, local connectivity, biophysical properties, and downstream projection targets. Odor processing in PCx is thought to occur in two sequential stages. First, SLs receive and integrate olfactory bulb input and then PYRs receive, transform, and transmit SL input. To test this model, we recorded from populations of optogenetically identified SLs and PYRs in awake, head-fixed mice. Notably, silencing SLs did not alter PYR odor responses, and SLs and PYRs exhibited differences in odor tuning properties and response discriminability that were consistent with their distinct embeddings within a sensory-associative cortex. Our results therefore suggest that SLs and PYRs form parallel channels for differentially processing odor information in and through PCx.</p>
Parallel processing by distinct classes of principal neurons in the olfactory cortex
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Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution
GEO Series GSE239477. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Molecular signatures of neural connectivity in the olfactory cortex
GEO Series GSE70800. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Higher-Order Olfactory Threat Associations in the Amygdala-Posterior Piriform Cortex Network
GEO Series GSE280826. Rattus norvegicus. 48 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Gene expression analysis of brain cortex of olfactory-bulbectomized rats
GEO Series GSE9789. Rattus norvegicus. 11 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.