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ShareScore release 0.9.0
Dataset results
8 results for “orthohantavirus”
Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage
<p>Evolutionary divergence of viruses is most commonly driven by co-divergence with their hosts or through isolation of transmission after host-shifts. It remains mostly unknown, however, whether divergent phylogenetic clades within named virus species represent functionally equivalent byproducts of high evolutionary rates or rather incipient virus species. Here, we test these alternatives with genomic data from two widespread phylogenetic clades in Tula orthohantavirus (TULV) within a single evolutionary lineage of their natural rodent host, the common vole Microtus arvalis. We examined voles from 42 locations in the contact region between clades for TULV infection by RT-PCR. Sequencing yielded 23 TULV Central North and 21 TULV Central South genomes which differed by 14.9-18.5% at the nucleotide and 2.2-3.7% at the amino acid level without evidence of recombination or reassortment. Geographic cline analyses demonstrated an abrupt (<1 km wide) transition between the parapatric TULV clades in continuous landscape. This transition was located within the Central mitochondrial lineage of M. arvalis and genomic SNPs showed gradual mixing of host populations across it. Genomic differentiation of hosts was much weaker across the TULV Central North to South transition than across the nearby hybrid zone between two evolutionary lineages in the host. We suggest that these parapatric TULV clades represent functionally distinct, incipient species which are likely differently affected by genetic polymorphisms in the host. This highlights the potential of natural viral contact zones as systems for investigating of the genetic and evolutionary factors enabling or restricting the transmission of RNA viruses.</p>
Data from: Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells
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Data from: Genome-wide support for incipient Tula orthohantavirus species within a single rodent host lineage
Open the record for dataset details and reuse information.
Virus isolation data improve host predictions for New World rodent orthohantaviruses
<p>Data and code for "Virus isolation data improve host predictions for New World rodent orthohantaviruses" in Journal of Animal Ecology</p>
Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells
GEO Series GSE245916. Rattus norvegicus; Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Human and rodent cell susceptibility and response to different orthohantaviruses uncovers various levels of cellular restriction
GEO Series GSE198751. Myodes glareolus. 12 samples. Type: Expression profiling by high throughput sequencing.
Maturing Neutrophils of Lower Density Associate with Thrombocytopenia in Puumala Orthohantavirus-Caused Hemorrhagic Fever with Renal Syndrome - Human samples
GEO Series GSE270609. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
A three-dimensional vessel-on-chip model to study Puumala orthohantavirus pathogenesis
GEO Series GSE270172. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.