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10 results for “ospC”
Diversity and host specificity of Borrelia burgdorferi's outer surface protein C (ospC) alleles in synanthropic mammals, with a notable ospC allele U absence from mixed infections
<p>Interactions among pathogen genotypes that vary in host specificity may affect overall transmission dynamics in multi-host systems. <em>Borrelia burgdorferi</em>, a bacterium that causes Lyme disease, is typically transmitted among wildlife by <em>Ixodes</em> ticks. Despite the existence of many alleles of <em>B. burgdorferi</em>'s <em>sensu stricto</em> outer surface protein C (<em>ospC</em>) gene, most human infections are caused by a small number of <em>ospC</em> alleles ["human infectious alleles" (HIAs)], suggesting variation in host specificity associated with <em>ospC</em>. To characterize the wildlife host association of <em>B. burgdorferi</em>'s <em>ospC</em> alleles, we used metagenomics to sequence <em>ospC</em> alleles from 68 infected individuals belonging to eight mammalian species trapped at three sites in suburban New Brunswick, New Jersey (USA). We found that multiple allele ("mixed") infections were common. HIAs were most common in mice (<em>Peromyscus</em> spp.) and only one HIA was detected at a site where mice were rarely captured. <em>OspC </em>allele U was exclusively found in chipmunks (<em>Tamias striatus</em>), and although a significant number of different alleles were observed in chipmunks, including HIAs, allele U never co-occurred with other alleles in mixed infections. Our results suggest that allele U may be excluding other alleles, thereby reducing the capacity of chipmunks to act as reservoirs for HIAs.</p>
Prevalence of Borrelia burgdorferi and diversity of its outer surface protein C (ospC) alleles in blacklegged ticks (Ixodes scapularis) in Delaware
<p>Characterizing the diversity of genes associated with virulence and transmission of a pathogen across the pathogen's distribution can inform our understanding of host infection risk. <em>Borrelia burgdorferi</em> is a vector-borne bacterium that causes Lyme disease in humans and is common in the United States. The outer surface protein C (<em>ospC</em>) gene of <em>B</em>. <em>burgdorferi</em> exhibits substantial genetic variation across the pathogen's distribution and plays a critical role in virulence and transmission in vertebrate hosts. In fact, <em>B. burgdorferi </em>infections that disseminate across host tissues in humans are associated with only a subset of <em>ospC</em> alleles. Delaware has a high incidence of Lyme disease, but the diversity of <em>ospC</em> in <em>B. burgdorferi</em> in the state has not been evaluated. We used PCR to amplify <em>ospC</em> in <em>B. burgdorferi</em>-infected blacklegged ticks (<em>Ixodes</em> <em>scapularis</em>) in sites statewide and used short-read sequencing to identify <em>ospC</em> alleles. <em>B. burgdorferi</em> prevalence in blacklegged ticks varied across sites, but not significantly so. We identified 15 previously characterized <em>ospC</em> alleles accounting for nearly all of the expected diversity of alleles across the sites as estimated using the Chao1 index. Nearly 40% of sequenced infections (23/58) had more than one <em>ospC</em> allele present suggesting mixed strain infections and the relative frequencies of alleles in single infections were positively correlated with their relative frequencies in mixed infections. Turnover of ospC alleles was positively related to distance between sites with closer sites having more similar allele compositions than more distant sites. This suggests a degree of <em>B. burgdorferi</em> dispersal limitation or habitat specialization. <em>OspC</em> alleles known to cause disseminated infections in humans were found at the highest frequencies across sites, corresponding to Delaware's high incidence of Lyme disease.</p>
Prevalence of Borrelia burgdorferi and diversity of its outer surface protein C (ospC) alleles in blacklegged ticks (Ixodes scapularis) in Delaware
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Diversity and host specificity of Borrelia burgdorferi's outer surface protein C (ospC) alleles in synanthropic mammals, with a notable ospC allele U absence from mixed infections
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Borrelia burgdorferi ospC mixes
<p>In silico mixes of ospC reads. Reads either contain Illumina errors (labeled error) or are errorFree (errFree). ospC genotype is followed by mixture proportion (BA.02.98_errFree_R1.fq contains 2% ospC type B and 98% ospC type A reads). All mixture files contain 300 reads; I redid sampling so there should be no sampling error.</p> <p>Use tar -jxvf mix.tar.bz2 to extract the file archive.</p>
Cross-reactivity of antibody responses to Borrelia afzelii OspC
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Data from: Within-host competition between Borrelia afzelii ospC strains in wild hosts as revealed by massively parallel amplicon sequencing
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Shigella Sonnei OSPC-rDT Conjugate Vaccine
ClinicalTrials.gov study NCT01399424. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Role of OspC effectors in the IFN response
GEO Series GSE200447. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Inferring Epitopes of a Polymorphic Antigen Amidst Broadly Cross-Reactive Antibodies Using Protein Microarrays: a Study of OspC Proteins of Borrelia burgdorferi
GEO Series GSE45996. Borreliella burgdorferi; Peromyscus leucopus; Homo sapiens. 110 samples. Type: Protein profiling by protein array.
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OpenNeuro
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