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ShareScore release 0.9.0
Dataset results
19 results for “pQCT”
Figure 4. pQCT images from a in The effects of locomotion on the structural characteristics of avian limb bones
Figure 4. pQCT images from a subset of the study species included, representing the range of geometries in the data set. Species not shown to same scale.
HR-pQCT demo images
<p>Demo images used in Jupyter notebooks of the JC MSK community for educational purpose</p>
Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
ClinicalTrials.gov study NCT03429426. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis
ClinicalTrials.gov study NCT02765074. IPD Sharing: NO. Countries: 1. Publications: 10.
Comparison of Bone Microarchitecture Analysed by HRpQCT and pQCT in Pathologies With Bone Loss and/or Muscle Loss
ClinicalTrials.gov study NCT06541548. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation by HR-pQCT of Bone Microarchitecture Changes in Patients With Rheumatoid Arthritis Under Anti-TNF Therapy.
ClinicalTrials.gov study NCT02526992. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Bone Quality by vQCT and HR-pQCT:Translation to Multi-center Clinical Research
ClinicalTrials.gov study NCT01544660. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Analysis of Bone Microarchitecture With HR-pQCT of Patients With Chronic Kidney Disease (CKD) Candidates for Renal Transplantation
ClinicalTrials.gov study NCT02523209. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
ClinicalTrials.gov study NCT03251430. IPD Sharing: NO. Countries: 1. Publications: 0.
Bone Microarchitecture Evaluation by HR-pQCT in Youngs Who Developed AN in Peri or Prepubertal Period.
ClinicalTrials.gov study NCT02526927. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Achieving SDAI Remission on Joint Space Outcomes Progression in Early Rheumatoid Arthritis: an HR-pQCT Study
ClinicalTrials.gov study NCT04324892. IPD Sharing: NO. Countries: 1. Publications: 0.
Bone Microstructure After Gastrectomy Evaluating by Using HR-pQCT
ClinicalTrials.gov study NCT03398226. IPD Sharing: NO. Countries: 1. Publications: 0.
Bone Microarchitectural Database Constitution From HR-pQCT Device in Clinical Situation Potentially Associated With Bone Loss
ClinicalTrials.gov study NCT02532439. IPD Sharing: NO. Countries: 1. Publications: 0.
Normative Database for HR-pQCT-Based Radius and Tibia Strength
ClinicalTrials.gov study NCT03219099. IPD Sharing: NO. Countries: 1. Publications: 0.
Fracture Healing Assessed by HR-pQCT After Administration of Calcium and Vitamin D
ClinicalTrials.gov study NCT02889237. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of Bone Micro-Architecture Using HR-pQCT
ClinicalTrials.gov study NCT01367730. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Bone Microstructure by Using HR-pQCT After Esophagectomy
ClinicalTrials.gov study NCT05812235. IPD Sharing: NO. Countries: 0. Publications: 0.
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Tibia - pQCT)
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of complete unloading. More recently, the effects of partial unloading on the musculoskeletal system have been interrogated in mice and rats, revealing dose-dependent effects of partial weight bearing (PWB) on the skeleton and skeletal muscle. Here, we extended these studies to determine the structural and functional skeletal alterations in 14-week-old male Wister rats exposed to 20%, 40%, 70%, or 100% of body weight for 1, 2, or 4 weeks (n equals 11–12/group). Using in vivo pQCT, we found that trabecular bone density at the proximal tibia declined in proportion to the degree of unloading and continued progressively with time, without evidence of a plateau by 4 weeks. Ex vivo measurements of trabecular microarchitecture in the distal femur by microcomputed tomography revealed deficits in bone volume fraction, 2 and 4 weeks after unloading. Histologic analyses of trabecular bone in the distal femur revealed the decreased osteoblast number and mineralizing surface in unloaded rats. Three-point bending of the femoral diaphysis indicated modest or no reductions in femoral stiffness and estimated modulus due to PWB. Our results suggest that this rat model of PWB leads to trabecular bone deterioration that is progressive and generally proportional to the degree of PWB, with minimal effects on cortical bone. This study derives results from the pQCT assay using tibia tissue.
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats (Tibia; pQCT)
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle strength in micro- and partial-gravity environments (e.g., the Moon or Mars) is not fully understood. The purpose of this study was to determine the influence of gonadectomy (castration/ovariectomy) on progression of muscle atrophy in both micro- and partial-gravity environments in male and female rats. Male and female Fischer rats (n equals 120) underwent castration/ovariectomy (CAST/OVX) or sham surgery (SHAM) at 11 weeks of age. After 2 weeks of recovery, rats were exposed to hindlimb unloading (0g), partial weight bearing at 40% of normal loading (0.4g, Martian gravity), or normal loading (1.0g) for 28 days. In males, CAST did not exacerbate body weight loss or other metrics of musculoskeletal health. In females, OVX animals tended to have greater body weight loss and greater gastrocnemius loss. Within 7 days of exposure to either microgravity or partial gravity, females had detectable changes to estrous cycle, with greater time spent in low-estradiol phases diestrus and metestrus (∼47% in 1g vs. 58% in 0g and 72% in 0.4g animals, P equals 0.005). We conclude that in males testosterone deficiency at the initiation of unloading has little effect on the trajectory of muscle loss. In females, initial low estradiol status may result in greater musculoskeletal losses. This study derives results from pQCT (Peripheral quantitative computed tomography).
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.