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342 results for “papillary”
Case report: Papillary squamous cell carcinoma of the penis
<p><strong>Case history</strong></p> <p>62-year-old male with a verruciform tumor located in distal penis and involving glans.</p> <p> </p> <p><strong>Histologic findings</strong></p> <p>The microphotographs show an exophytic verruciform tumor mass characterized by papillomatosis, slight to moderate acanthosis, and hyperkeratosis. Papillae are complex, some with blunt and others with spiky tips. Fibrovascular are present in most but not all papillae and are irregularly shaped. Tumor base is jagged and there is a prominent stromal reaction. Neoplastic cells in papillae and infiltrative tumor nests are well to moderately differentiated (grades 1-2) and no koilocytic atypia is observed.</p> <p> </p> <p><strong>Discussion</strong></p> <p>Verruciform penile tumors comprise about one-quarter of all penile squamous cell carcinomas (SCC) and include papillary, verrucous, and warty carcinomas, as well as giant condylomas and carcinoma cuniculatum. As a group, verruciform carcinomas are characterized by the presence of papillomatosis, acanthosis, and hyperkeratosis. However, there are distinctive morphological features for each one of these tumors. For papillary SCC, the most distinguishing feature is the presence of complex papillae with irregularly shaped fibrovascular cores. Papillary carcinomas tend to be polymorphic with some areas exhibiting condylomatous papillae and others with a more verrucous-like aspect. Fibrovascular cores are readily found in the former and are scant or even absent in the latter.</p> <p>Another important clue in the differential diagnosis with other verruciform tumors is the presence of a jagged tumor-stroma interface. In verrucous and cuniculatum carcinomas the tumor front is broad-based. The absence of koilocytosis allows the distinction from warty carcinomas and giant condylomas, tumors in which koilocytes are conspicuous. HPV status may be helpful in problematic cases, since in papillary carcinomas the HPV detection rate is very low or even null. Immunohistochemistry for p16<sup>INK4a</sup> is also useful since the vast majority of papillary carcinomas do not overexpress this protein. In order for a penile tumor to be considered as p16<sup>INK4a</sup> positive all neoplastic cells should be stained. Cases like this one in which some cells stain and others do not should be regarded as negative for p16<sup>INK4a</sup> overexpression.</p> <p>The inguinal metastatic rate of penile papillary carcinomas is very low and the prognosis is good. Less than one-fifth of all patients present inguinal involvement and even in these cases the mortality rate is low. Even when tumors invade penile erectile tissues prognosis is good as long as no high-grade areas (observed in a minority of the patients) are identified.</p> <p>Clinically patients should be managed using risk-group stratification systems and taking into account histological grade, anatomical level of maximum tumor infiltration, and the presence of vascular and perineural invasion. </p> <p> </p> <p><strong>References</strong></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/20061934">Chaux et al. Am J Surg Pathol. 2010 34(2): 223-30</a></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22641955">Chaux & Cubilla. Semin Diagn Pathol. 2012 29(2): 72-82</a></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22641955">Chaux & Cubilla. Semin Diagn Pathol. 2012 29(2): 67-71</a></p>
Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer
ClinicalTrials.gov study NCT00537095. IPD Sharing: YES. Countries: 7. Publications: 1.
Supplemental Table. Historical cohort of 560 well-described papillary craniopharyngiomas reported in the medical literature (560c).
<p><span>Table </span><span>listing the historical cohort of </span><span>560 </span><span>well-described/illustrated individual papillary craniopharyngiomas reported in the medical literature, including their corresponding references.</span><span><span><span> </span></span></span></p>
Spatial transcriptomics images for papillary and anaplastic thyroid cancer IRIBHM dataset
<p>This dataset includes the image files for spatial transcriptomics data associated with the publication "Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers".</p>
A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer
ClinicalTrials.gov study NCT01130519. IPD Sharing: YES. Countries: 1. Publications: 4.
A Study of Radiation Therapy and Paclitaxel and Carboplatin in Patients With Uterine Papillary Serous Carcinoma
ClinicalTrials.gov study NCT00231868. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase II Study of GSK1363089 (Formerly XL880) for Papillary Renal-Cell Carcinoma (PRC)
ClinicalTrials.gov study NCT00726323. IPD Sharing: YES. Countries: 1. Publications: 1.
Papillary Serous Carcinoma of the Endometrium
ClinicalTrials.gov study NCT00515073. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Vemurafenib (RO5185426) in Participants With Metastatic or Unresectable Papillary Thyroid Cancer Positive for the BRAF V600 Mutation
ClinicalTrials.gov study NCT01286753. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Endoscope-assisted Flapless Approach Versus Papillary Preservation Technique in Periodontal Regeneration.
ClinicalTrials.gov study NCT06978036. IPD Sharing: NO. Countries: 1. Publications: 0.
Re-differentiation of Radioiodine-Refractory BRAF V600E-mutant Papillary Thyroid Carcinoma With GSK2118436
ClinicalTrials.gov study NCT01534897. IPD Sharing: NO. Countries: 1. Publications: 1.
Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in People With Low-risk Papillary Thyroid Cancer
ClinicalTrials.gov study NCT02408887. IPD Sharing: YES. Countries: 1. Publications: 3.
Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma
ClinicalTrials.gov study NCT05287945. IPD Sharing: NO. Countries: 2. Publications: 7.
RAPTOR: RAD001 as Monotherapy in the Treatment of Advanced Papillary Renal Cell Tumors Program in Europe
ClinicalTrials.gov study NCT00688753. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Selumetinib in Treating Patients With Papillary Thyroid Cancer That Did Not Respond to Radioactive Iodine
ClinicalTrials.gov study NCT00559949. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Preoperative Prediction of Lymph Node Metastasis in T1N0M0 Papillary Thyroid Carcinoma by Using Contrast-enhanced Ultrasound
ClinicalTrials.gov study NCT07357571. IPD Sharing: YES. Countries: 1. Publications: 11.
Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
ClinicalTrials.gov study NCT02116309. IPD Sharing: Not stated. Countries: 2. Publications: 5.
Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) Versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
<p>Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic adenocarcinoma tumor resection patients at the University of Kansas Hospital between August 2009 and March 2019. Patients were divided into one of two groups, PanIN or IPMN, based on the results of the surgical pathology report. We compared baseline characteristics, overall survival (OS), and progression free survival (PFS) between the two groups, as well as OS and PFS based on local or distant tumor recurrence for both groups combined. 52 patients had PanINs and 20 patients had IPMNs. Patients who had an IPMN precursor lesion had better median PFS and OS when compared to patients with PanIN precursor lesions. However, the location of tumor recurrence (local or distant) did not show a statistically significant difference in OS.</p>
Fig. 6 in Nuptial pads of rock frogs (Thoropa, Cycloramphidae, Anura): How papillary epidermal projections are related to sexual maturity and taxonomy
Fig. 6. Violin plots of the number of papillary epidermal projections (PEPs) on the left metacarpal-phalangeal articulation of finger II (MPA-II), the left inner metacarpal tubercle (IMT), the left whole finger II (M II + P-II), and the left finger III, grouped by species, with corresponding Kruskal–Wallis H statistics and Pvalues. The sample size is given below the species names.
Fig. 1 in Nuptial pads of rock frogs (Thoropa, Cycloramphidae, Anura): How papillary epidermal projections are related to sexual maturity and taxonomy
Fig. 1. Photos of the three basic types and distribution of papillary epidermal projections (PEPs) of Thoropa. (A, B) Dorsal and ventral views of the hand of a specimen of Thoropa lutzi from Rio de Janeiro, Rio de Janeiro state, Brazil (MZUSP 88241) showing cone-shaped PEPs (not the focus of the present study). (C, D) Dorsal and ventral views of the hand of a specimen of Thoropa petropolitana from Guapimirim, Rio de Janeiro state, Brazil (EI 9474) showing spineshaped PEPs located only on the metacarpalphalangeal articulation of finger II (MPA-II). (E, F) Dorsal and ventral views of the hand of a specimen of Thoropa taophora from S˜ao Sebasti˜ao, S˜ao Paulo state, Brazil (EI 9474) showing spine-shaped PEPs on the metacarpal-phalangeal articulation of finger II (MPAII), inner metacarpal tubercle (IMT), other regions of finger II, finger III, and finger IV.
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Allen Brain Atlas
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