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285 results for “paracetamol”
Dataset of Raman spectroscopy responses for over-the-counter drugs in Paraguay, including acetylsalicylic acid, paracetamol, and ibuprofen.
<p>Spectra of three over-the-counter pharmaceuticals—acetylsalicylic acid, paracetamol, and ibuprofen—were collected at the Faculty of Exact and Natural Sciences of the National University of Asuncion, with the aim of creating a dataset that serves as a reference for Raman responses from different drug manufacturers. This dataset will also provide the scientific community with data that can be used for multivariate analysis and model training.</p> <p>In the data collection phase, spectra were obtained using a Raman spectroscopy system (iRaman 785s model from BWTEK) equipped with a 785 nm excitation laser. Samples were collected from diverse sales points such as pharmacies, shopping centers, and street vendors. Each spectrum was captured at 50% laser power with a measurement time of 1 second and an accumulation of 10 spectra over a range of 150 to 3200 cm-1. This method preserved the integrity of the raw data, which includes a common column for Raman shifts and additional columns for intensities and labels, detailing the activation modes in the Raman spectrum.</p> <p>The data is structured into specific xlsx files for each drug, such as "Paracetamol.xlsx", "acetylsalicylic-acid .xlsx", and "Ibuprofen .xlsx", each containing 50 spectra categorized by the type of pharmaceutical but not by brand. Brand-specific categorization is detailed in separate files like "Paracetamol-trademark .xlsx", where samples are classified using codes such as "Par-A" for different brands. This organization aids the scientific community in using clustering methods to analyze the spectral data and differentiate pharmaceutical brands based on their excipients or binders, with consistent codes across different drugs suggesting common manufacturers for various medications.</p> <p> </p>
Stocks of paracetamol products stored in urban New Zealand households: A cross-sectional study
<p><b>Background</b></p> <p>Intentional self-harm is a common cause of hospital presentations in New Zealand and across the world, and self-poisoning is the most common method of self-harm. Paracetamol (acetaminophen) is frequently used in impulsive intentional overdoses, where ease of access may determine the choice of substance.</p> <p><b>Objective</b></p> <p>This cross-sectional study aimed to determine how much paracetamol is present and therefore accessible in urban New Zealand households, and sources from where it has been obtained. This information is not currently available through any other means, but could inform New Zealand drug policy on access to paracetamol.</p> <p><b>Methods</b></p> <p>Random cluster-sampling of households was performed in major urban areas of two cities in New Zealand, and the paracetamol-containing products, quantities, and sources were recorded. Population estimates of proportions of various types of paracetamol products were calculated.</p> <p><b>Results</b></p> <p>A total of 174 of the 201 study households (86.6%) had at least one paracetamol product. Study households had mostly prescription products (78.2% of total mass), and a median of 24.0 g paracetamol present per household (inter-quartile range 6.0-54.0 g). Prescribed paracetamol was the main source of large stock. Based on the study findings, 53% of New Zealand households had 30 g or more paracetamol present, and 36% had 30 g or more of prescribed paracetamol, specifically.</p> <p><b>Conclusions</b></p> <p>This study highlights the importance of assessing whether and how much paracetamol is truly needed when prescribing and dispensing it. Convenience of appropriate access to therapeutic paracetamol needs to be balanced with preventing unnecessary accumulation of paracetamol stocks in households and inappropriate access to it. Prescribers and pharmacists need to be aware of the risks of such accumulation and assess the therapeutic needs of their patients. Public initiatives should be rolled out at regular intervals to encourage people to return unused or expired medicines to pharmacies for safe disposal.</p>
Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis
ClinicalTrials.gov study NCT01540838. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
PP100-01 (Calmangafodipir) for Overdose of Paracetamol
ClinicalTrials.gov study NCT03177395. IPD Sharing: NO. Countries: 1. Publications: 2.
Paracetamol in Addition to WHO Step III Opioids in Chronic Cancer Pain Control
ClinicalTrials.gov study NCT05088876. IPD Sharing: YES. Countries: 1. Publications: 1.
Intravenous Paracetamol in Combination With Caudal Ropivacaine
ClinicalTrials.gov study NCT03781505. IPD Sharing: NO. Countries: 1. Publications: 10.
Stocks of paracetamol products stored in urban New Zealand households: A cross-sectional study
Open the record for dataset details and reuse information.
The Effects of Tramadol and Paracetamol on Physical Performance, Brain Dynamics and Sustained Attention During Cycling Exercise: A Double Blind Randomized Placebo-Controlled Clinical Trial
<p>The purposes of the current project are: 1) to investigate further the effect of Tramadol on cycling (at the physical, cognitive and brain levels) on the basis of the preliminary results of the TRAWADA2015 study (<a href="https://zenodo.org/deposit/1308615">https://zenodo.org/deposit/1308615</a>); 2) to study the effect of paracetamol at the physical, cognitive and brain levels during an aerobic and anaerobic exercise on cycle-ergometer, and compare it to that of tramadol</p>
Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain
ClinicalTrials.gov study NCT02625753. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical Study Comparing the Efficacy of Transbuccal Paracetamol 125 mg Versus Paracetamol Injection 1g in Slow Infusion IV in Patients With Acute Pain
ClinicalTrials.gov study NCT01586143. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
ClinicalTrials.gov study NCT05757388. IPD Sharing: NO. Countries: 1. Publications: 6.
Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage
ClinicalTrials.gov study NCT01993589. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Intravenous Paracetamol in Manament of Labour Pain
ClinicalTrials.gov study NCT04744727. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Oral Paracetamol Compared With Oral Ketoprofen for Pain Management in Office Hysteroscopy
ClinicalTrials.gov study NCT07315698. IPD Sharing: NO. Countries: 1. Publications: 3.
Drug Provocation Test (DPT) to Paracetamol
ClinicalTrials.gov study NCT03771118. IPD Sharing: NO. Countries: 1. Publications: 0.
Heamodynamic Effects of Paracetamol in Septic Shock Patients
ClinicalTrials.gov study NCT06076980. IPD Sharing: NO. Countries: 1. Publications: 1.
A PhaseⅡ/ Ⅲ Seamless Study to Evaluate Efficacy and Safety of Paracetamol Injection as Adjuvant to Morphine-based Postoperative Analgesia
ClinicalTrials.gov study NCT02811991. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries
ClinicalTrials.gov study NCT04199572. IPD Sharing: NO. Countries: 1. Publications: 19.
Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?
ClinicalTrials.gov study NCT00488540. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Safety of Paracetamol as Antipyretic in Treatment of Dengue Infection in Adults
ClinicalTrials.gov study NCT02833584. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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