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Dataset results
30 results for “paraneoplastic”
Immune and genetic signature of HER2-driven breast carcinomas triggering anti-Yo paraneoplastic cerebellar degeneration
<ul> <li>Supplementary eTables from: Immune and genetic signature of HER2-driven breast carcinomas triggering anti-Yo paraneoplastic cerebellar degeneration: <ul> <li><strong>eTables 1</strong>: Results of DESeq2 on the differential gene expression analysis between Yo-PCD and control tumours for all genes and for differentially expressed genes.</li> <li><strong>eTables 2</strong>: Results of the Gene Ontology enrichment performed by clusterProfiler on genes over-expressed in Yo-PCD tumours</li> <li><strong>eTables 3</strong>: Results of the Gene Ontology enrichment performed by clusterProfiler on genes under-expressed in Yo-PCD tumours</li> </ul> </li> <li>Gene counts</li> <li>Gene TPMs</li> </ul>
Immunotherapy of the Paraneoplastic Syndromes
ClinicalTrials.gov study NCT00378326. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Paraneoplastic Neurologic Encephalitis and Mature Cystic Teratoma
ClinicalTrials.gov study NCT05223543. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Immunotherapy and Paraneoplastic Neurological Syndromes
ClinicalTrials.gov study NCT02343211. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Paraneoplastic Syndrome in Hepatocellular Carcinoma Patients
ClinicalTrials.gov study NCT05846035. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Data from: Paraneoplastic neuronal intermediate filament autoimmunity
Objective: To describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity. Methods: Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by western blot and mass spectrometry. NIF specificity was confirmed by dual tissue section staining and 5 recombinant NIF-specific HEK293 cell based assays (CBAs, for alpha internexin, neurofilament light [NF-L], medium, or heavy chain, and peripherin). NIF-IgGs were correlated with neurological syndromes and cancers. Results: Among 65 patients, NIF-IgG positive by IFA and CBAs, 33 were female (51%). Median symptom-onset age was 62 years (range, 18-88). Patients fell into 2 groups, defined by the presence of NF-L-IgG (21 patients, who mostly had ≥4 NIF-IgGs detected) or its absence (44 patients, who mostly had ≤2 NIF-IgGs detected). Among NF-L-IgG positive patients, 19/21 had ≥1 subacute onset CNS disorders: cerebellar ataxia (11), encephalopathy (11); myelopathy (2). Cancers were detected in 16 of 21 patients (77%): carcinomas of neuroendocrine lineage (10) being most common (small cell [5], Merkel cell [3], other neuroendocrine [2]). Two of 257 controls (0.8%, both with small cell carcinoma) were positive by both IFA and CBA. Five of 7 patients with immunotherapy data improved. By comparison, the 44 NF-L-IgG negative patients had findings of unclear significance: diverse nervous system disorders (p=0.006), as well as limited (p=0.003) and more diverse (p<0.0001) cancer accompaniments. Conclusions: NIF-IgG detection by IFA, with confirmatory CBA testing that yields a profile including NF-L-IgG, defines a paraneoplastic CNS disorder (usually ataxia or encephalopathy) accompanying neuroendocrine lineage neoplasia.
Early Immunotherapy with Intravenous Immunoglobulin, Cyclophosphamide and Methylprednisolone in Patients with Anti-Hu-associated Paraneoplastic Sensory Neuronopathy
ClinicalTrials.gov study NCT06373211. IPD Sharing: YES. Countries: 1. Publications: 0.
Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer
ClinicalTrials.gov study NCT07063550. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Paraneoplastic neuronal intermediate filament autoimmunity
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Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma
GEO Series GSE189743. Homo sapiens. 184 samples. Type: Expression profiling by high throughput sequencing; Other.
Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma [TCR-Seq]
GEO Series GSE189742. Homo sapiens. 57 samples. Type: Other.
Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome
GEO Series GSE251715. Drosophila melanogaster. 5 samples. Type: Expression profiling by high throughput sequencing.
Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma [RNA-Seq]
GEO Series GSE189367. Homo sapiens. 64 samples. Type: Expression profiling by high throughput sequencing.
Hodgkin lymphoma cell lines and tissues express mGluR5: a potential link to Ophelia syndrome and paraneoplastic neurological disease
GEO Series GSE212326. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Paraneoplastic Secretion of Multiple Phosphatonins from a Deep Fibrous Histiocytoma Causing Oncogenic Osteomalacia
GEO Series GSE160445. Homo sapiens. 6 samples. Type: Expression profiling by array.
Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma [BCR-Seq]
GEO Series GSE189741. Homo sapiens. 63 samples. Type: Other.
Methylated DNA Detect in Paraneoplastic Syndrome of Nervous System
ClinicalTrials.gov study NCT04454853. IPD Sharing: NO. Countries: 1. Publications: 0.
The Study of Immune Cell (T Cell) Activity in Patients With Paraneoplastic Neurologic Syndromes
ClinicalTrials.gov study NCT00327236. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevalence+Significance of Paraneoplastic Autoantibodies in Many Cancers
ClinicalTrials.gov study NCT00608452. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Incidence of Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis
ClinicalTrials.gov study NCT03957616. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.