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Dataset results
8 results for “pathogen characterisation”
Omic characterisation of multi-component defences against the necrotrophic pathogen Pyrenophora tritici-repentis in wheat
<p>Supplementary data for a paper submission. The abstract is below. </p> <p> </p> <p><span><span>·<span> </span></span></span>Tan Spot disease is caused by the necrotrophic pathogen <em>Pyrenophora tritici-repentis</em> (<em>Ptr</em>) and poses a significant threat to global wheat production. Therefore, novel sources of resistance need to be identified, coupled with a fuller mechanistic understanding of host responses to <em>Ptr.</em></p> <p><span><span>·<span> </span></span></span>Herein, we characterise the interaction between <span>a <span>ToxA</span>-positive <em>Ptr</em> strain and parental wheat lines from a multiparent advanced generation intercross (MAGIC) population. Genotypes displaying moderate resistance (‘Robigus’) or susceptibility (‘Hereward’) to <em>Ptr </em>challenge were identified and characterised through histological, metabolomic, and transcriptomic approaches.</span></p> <p><span><span>·<span> </span></span></span><span>Histological investigations indicated the prominence of papilla-based defences in Robigus. Transcriptomic analyses could link this to the expression of barrier-related genes i.e. </span>actin polymerisation, callose deposition, vesicle trafficking, and cellulose synthesis. Inhibiting actin polymerisation with cytochalasin E increased lesion numbers but did not augment lesion growth, suggesting the deployment of other defence mechanisms. These may be influenced by auxin, as its exogenous application exacerbated symptom development.</p> <p><span><span>·<span> </span></span></span>Transcriptomic and metabolomic analyses in Hereward following challenge with <em>Ptr</em> suggested shifts in primary metabolism, affecting glycolysis, the TCA cycle, and the γ-<span>aminob</span>utyric acid (GABA) shunt. Activation of salicylic acid (SA)-associated genes, including NPR1 and WRKY33, was specific to Hereward, and exogenous SA increased susceptibility to <em><span>Ptr </span></em><span>in both genotypes</span>.</p> <p><span><span>·<span> </span></span></span>This study suggests <span>barrier defences </span>could be effective against <em><span>Ptr </span></em><span>as well as a lack of </span>susceptibility factors like SA or the appropriate processing of IAA. These findings offer potential avenues for enhancing wheat resistance to <em>Ptr</em>.</p>
Characterisation Of The Excreted Virome In The Population: NGS Tools And Epidemiologically Significant Pathogens
<p>Metagenomic analysis of virus in raw sewage.</p>
Characterisation of a pathogenic non-migratory fibroblast population in systemic sclerosis skin [scRNA-Seq]
GEO Series GSE292979. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Characterisation of a pathogenic non-migratory fibroblast population in systemic sclerosis skin
GEO Series GSE292702. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Characterisation of Modular Reponse of non-pathogenic E.coli K12 MG1655 Response to acid adaptation, part B
GEO Series GSE13179. Escherichia coli; Escherichia coli str. K-12 substr. MG1655. 24 samples. Type: Expression profiling by array.
Characterisation of Modular Reponse of non-pathogenic E.coli O157 Sakai Response to acid adaptation
GEO Series GSE13180. Escherichia coli; Escherichia coli O157:H7 str. Sakai. 24 samples. Type: Expression profiling by array.
Characterisation of Modular Reponse of non-pathogenic E.coli K12 MG1655 and O157 Sakai Response to acid adaptation
GEO Series GSE13181. Escherichia coli; Escherichia coli str. K-12 substr. MG1655; Escherichia coli O157:H7 str. Sakai. 93 samples. Type: Expression profiling by array.
Characterisation of Modular Reponse of non-pathogenic E.coli K12 MG1655 Response to acid adaptation, part A
GEO Series GSE13178. Escherichia coli; Escherichia coli str. K-12 substr. MG1655. 45 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.