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9
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ShareScore release 0.9.0
Dataset results
9 results for “pathogen hotspot”
Data for: Multi-omics analysis identifies symbionts and pathogens of blacklegged ticks (Ixodes scapularis) from a Lyme disease hotspot in southeastern Ontario, Canada
<p>Ticks in the family Ixodidae are recognized as important vectors of zoonoses including Lyme disease (LD), which is caused by spirochete bacteria from the <em>Borreliella</em> (<em>Borrelia</em>) <em>burgdorferi</em> sensu lato (<em>Bbsl</em>) complex. The blacklegged tick (<em>Ixodes scapulars</em>) continues to expand across Canada, creating hotspots of elevated LD risk at the leading edge of its expansion range. Current efforts to understand the risk of pathogen transmission associated with <em>I. scapularis</em> in Canada focus primarily on targeted screens, while variation in the tick microbiome remains poorly understood. Using multi-omics consisting of 16S metabarcoding and ribosome-depleted, whole-shotgun RNA transcriptome sequencing, we examined the microbial communities associated with adult <em>I. scapularis</em> (N = 32), sampled from four tissue types (whole tick, salivary glands, midgut, and viscera) and three geographical locations within an LD hotspot near Kingston, Ontario. The communities consisted of both endosymbiotic and known or potentially pathogenic microbes, including RNA viruses, bacteria, and a <em>Babesia</em> sp. intracellular parasite. We show that β-diversity is significantly higher between individual tick salivary gland and midgut bacterial communities, compared to whole ticks; while linear discriminant analysis (LDA) effect size (LEfSe) determined that the three potentially pathogenic bacteria detected by V4 16S rDNA sequencing were also discriminatory for dissected tissues only, including a <em>Borrelia</em> from the <em>Bbsl</em> complex, <em>Borrelia miyamotoi</em>, and <em>Anaplasma phagocytophilum. </em>Importantly, we find co-infection of <em>I. scapularis</em> by multiple microbes, in contrast to diagnostic protocols for LD, which typically focus on infection from a single pathogen of interest (<em>B. burgdorferi</em> sensu stricto).</p>
Data for: Multi-omics analysis identifies symbionts and pathogens of blacklegged ticks (Ixodes scapularis) from a Lyme disease hotspot in southeastern Ontario, Canada
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Data and code for "Mapping hotspots of zoonotic pathogen emergence: an integrated model- and participatory-based approach"
<p>Code for "Mapping hotspots of zoonotic pathogen emergence: an integrated model- and participatory-based approach". Note shapefiles will need to be downloaded from GADM (https://gadm.org/), or from the gadm package in R (https://rdrr.io/github/rspatial/geodata/man/gadm.html). </p> <p>Data are available in Version 1.0 of this record</p>
Ecological barriers for an amphibian pathogen: a narrow ecological niche for Batrachochytrium salamandrivorans in an Asian Chytrid hotspot
<p>We used GLM and Maxent models to predict the potential distribution of <em>Batrachochytrium salamandrivorans </em>(<em>Bsal</em>)<em> </em>based on the climate, non-climate, and biotic variables.</p>
Data from: Diversification of an emerging pathogen in a biodiversity hotspot: Leptospira in endemic small mammals of Madagascar
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Pathogenic DICER1 RNase IIIb Hotspot Mutation Induces 3p-miRNA Gain-of-Function via Argonaute Strand Switch [CLASH]
GEO Series GSE279636. Mus musculus. 6 samples. Type: Other.
Pathogenic DICER1 RNase IIIb Hotspot Mutation Induces 3p-miRNA Gain-of-Function via Argonaute Strand Switch [RNA-seq]
GEO Series GSE279645. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Climate as a gatekeeper: Unexpected absence of Batrachochytrium salamandrivorans in an Asian Chytrid hotspot suggests a narrow climatic niche for the pathogen
<p>we conducted an extensive survey for <em>Batrachochytrium salamandrivorans </em>across the Guangxi region of Southern China, now considered a <em>B. dendrobatidis</em> hotspot. We examined 1230 individuals from 38 amphibian species and 36 environmental water bodies sampled. However, PCR testing revealed absence of <em>B. salamandrivorans </em> in our samples. A subsequent niche modeling analysis for <em>B.salamandrivorans </em> suggested that the bioclimatic conditions of much of the region may not be conducive to <em>B. salamandrivorans </em>.</p>
Pathogenic DICER1 RNase IIIb Hotspot Mutation Induces 3p-miRNA Gain-of-Function via Argonaute Strand Switch [miR-seq]
GEO Series GSE279556. Mus musculus; Homo sapiens. 26 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.