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70 results for “pathway dysregulation”
Interstage single ventricle heart disease infants show dysregulation in multiple metabolic pathways: targeted metabolomics analysis - Data
<p>The data in this Zenodo entry corresponds to the data used to produce the results in <a href="https://www.jacc.org/doi/full/10.1016/j.jacadv.2022.100169">https://www.jacc.org/doi/full/10.1016/j.jacadv.2022.100169</a>. The zipped folder contains three files</p> <ul> <li>Metabolite Data.csv - The meatobilte measurements for all the samples</li> <li>Clinical Data.csv - Values for the clinical variables</li> <li>Clinical Data Descriptions.csv - More in depth explanation of clinical variables as well as possible values of the variables</li> </ul> <p><span>This study was supported by the American Heart Association (AHA</span><span>20CDA35310498 and AHA18IPA34170070) and the National Institutes </span><span>of Health (NIH/NCATS Colorado CTSA, No. UL1 TR001082 and NIH/</span><span>NHLBI K23HL12363</span></p>
A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19.
<p>Improvements in COVID-19 treatments, especially for the critically ill, require deeper understanding of the mechanisms driving disease pathology. The complement system is a crucial component of innate host defense, but can also contribute to tissue injury. Although all complement pathways have been implicated in COVID-19 pathogenesis, the upstream drivers and downstream effects on tissue injury remain poorly defined. We demonstrate that complement activation is primarily mediated by the alternative pathway, and we provide a comprehensive atlas of the complement alterations around the time of respiratory deterioration. Proteomic and single-cell sequencing mapping across cell types and tissues reveals a division of labor between lung epithelial, stromal, and myeloid cells in complement production, in addition to liver-derived factors. We identify IL-6 and STAT1/3 signaling as an upstream driver of complement responses, linking complement dysregulation to approved COVID-19 therapies. Furthermore, an exploratory proteomic study indicates that inhibition of complement C5 decreases epithelial damage and markers of disease severity. Collectively, these results support complement dysregulation as a key druggable feature of COVID-19.</p>
Identifying Biomarkers & Dysregulated Biological Pathways in Blood and Urine of Congenital Central Hypoventilation Syndrome (CCHS) Patients
ClinicalTrials.gov study NCT06997146. IPD Sharing: YES. Countries: 1. Publications: 0.
Heterogenous radiomics patterns are associated with poor survivals and dysregulated pathways in medulloblastoma
GEO Series GSE151519. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Wnt-signaling pathways are dysregulated in female cerebellum following an early methyl donor deficiency in a rat nutritional model
GEO Series GSE104164. Rattus norvegicus. 7 samples. Type: Expression profiling by array.
Genomic profiling identifies genes and pathways dysregulated by HEY1-NCOA2 fusion and shed a light on mesenchymal chondrosarcoma tumorigenesis [RNA-seq]
GEO Series GSE196002. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Identification of pathological pathways centered on circRNA dysregulation associated with irreversible progression of Alzheimer’s disease [5xFADHippocampus]
GEO Series GSE272744. Mus musculus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Bi-allelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
GEO Series GSE85969. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis [ChIP-seq]
GEO Series GSE186197. Homo sapiens. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
GEO Series GSE139484. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patient
GEO Series GSE207533. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Alpha-synuclein overexpression is associated with epigenomic dysregulation of glutamate signaling and locomotor pathways
GEO Series GSE181126. Homo sapiens. 46 samples. Type: Methylation profiling by genome tiling array.
Targeted deletion of circadian clock gene Arntl in the nephron results in dysregulation of diverse metabolic pathways
GEO Series GSE76838. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Identification of pathological pathways centered on circRNA dysregulation associated with irreversible progression of Alzheimer’s disease [circGigyf2KD]
GEO Series GSE272745. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways
GEO Series GSE71664. Homo sapiens. 33 samples. Type: Expression profiling by array.
Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways [RNA-Seq 1]
GEO Series GSE293276. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
Dysregulation of pathways involved in the processing of cancer and microenvironment information in MCA+TPA transformed C3H/10T1/2 cells
GEO Series GSE41142. Mus musculus. 4 samples. Type: Expression profiling by array.
MECP2-related pathways are dysregulated in a cortical organoid model of Myotonic dystrophy [eCLIP]
GEO Series GSE201895. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
Dysregulation of adipocytokines regulated by hsa-miR-548ay-3p/PPARγ signaling pathway leaded to cardiac fibrosis
GEO Series GSE288419. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Meta-analysis of glioblastoma tissue RNA-seq datasets points to ferroptosis pathway dysregulation
GEO Series GSE214252. Homo sapiens. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.