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23
datasets available to search
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Dataset results
23 results for “pathway group”
Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
<p>Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart. Synthetic CVB3/28 RNA forms mimicking each of these major 5'TD virus populations were transfected in mice and have been shown to modulate innate immune responses in the heart and to induce myocarditis in mice. Remarkably, transfection of synthetic viral RNA with deletions in the secondary structures of the 5'-terminal CVB3 RNA domain I, modifying stem-loops "b", "c" or "d", were found to impair IFN-β production in human cardiomyocytes. In addition, the activation of innate immune response by Poly(I:C), was found to restore IFN-β production and to reduce the burden of CVB-5'TD RNA-forms in cardiac tissues, thereby reducing the mortality rate of infected mice. Overall, our results indicate that major early-emerging CVB3 populations deleted in the domain I of genomic RNA, in the 5' noncoding region, modulate the activation of the type I IFN pathway in cardiomyocytes and induce myocarditis in mice. These findings shed new light on the role of replicative CVB-5'TD RNA forms as key pathophysiological factors in CVB-induced human myocarditis.</p>
Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
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Group formation and the evolutionary pathway to complex sociality in birds
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Dateset The "blue eyed" in our school – overcoming stereotypes as the pathway to creating better conditions for pupil development in the school class - control group and equal socioeconomic status groups
<p>Dateset The “blue eyed” in our school – overcoming stereotypes as the pathway to creating better conditions for pupil development in the school class - control group and equal socioeconomic status groups</p>
Relabeling metabolic pathway data with groups to improve prediction outcomes
<p>We include samples of various data types used in the work "Relabeling metabolic pathway data with groups to improve prediction outcomes"</p> <p>More information about the software package and instructions are provided in <a href="https://github.com/hallamlab/reMap">hallamlab/reMap</a></p>
Mental Health Pathways in Internet Support Groups
ClinicalTrials.gov study NCT02396472. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
ClinicalTrials.gov study NCT05956912. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Auditory functional magnetic resonance imaging in dogs – normalization and group analysis and the processing of pitch in the canine auditory pathways
Background: Functional magnetic resonance imaging (fMRI) is an advanced and frequently used technique for studying brain functions in humans and increasingly so in animals. A key element of analyzing fMRI data is group analysis, for which valid spatial normalization is a prerequisite. In the current study we applied normalization and group analysis to a dataset from an auditory functional MRI experiment in anesthetized beagles. The stimulation paradigm used in the experiment was composed of simple Gaussian noise and regular interval sounds (RIS), which included a periodicity pitch as an additional sound feature. The results from the performed group analysis were compared with those from single animal analysis. In addition to this, the data were examined for brain regions showing an increased activation associated with the perception of pitch. Results: With the group analysis, significant activations matching the position of the right superior olivary nucleus, lateral lemniscus and internal capsule were identified, which could not be detected in the single animal analysis. In addition, a large cluster of activated voxels in the auditory cortex was found. The contrast of the RIS condition (including pitch) with Gaussian noise (no pitch) showed a significant effect in a region matching the location of the left medial geniculate nucleus. Conclusion: By using group analysis additional activated areas along the canine auditory pathways could be identified in comparison to single animal analysis. It was possible to demonstrate a pitch-specific effect, indicating that group analysis is a suitable method for improving the results of auditory fMRI studies in dogs and extending our knowledge of canine neuroanatomy.
Aggregating statistically correlated metabolic pathways into groups to improve pathway prediction outcomes
<p>We included files used in <a href="https://github.com/hallamlab/chap">hallamlab/chap</a></p>
Data from: Auditory functional magnetic resonance imaging in dogs – normalization and group analysis and the processing of pitch in the canine auditory pathways
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Expression evolution in gene groups: Inferring non-neutral regulatory change in pathways from transcriptional profiling data
GEO Series GSE38875. Saccharomyces mikatae; Saccharomyces cerevisiae x Saccharomyces bayanus; Saccharomyces bayanus; Saccharomyces cerevisiae; Saccharomyces cerevisiae x Saccharomyces mikatae; Saccharomyces paradoxus; Saccharomyces cerevisiae x Saccharomyces paradoxus. 18 samples. Type: Expression profiling by high throughput sequencing.
Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesi
GEO Series GSE131914. Mus musculus. 59 samples. Type: Expression profiling by high throughput sequencing.
Representative Western blots showing the ratio of total expression of phosphorylated and unphosphorylated proteins involved in insulin signaling pathway in the red gastrocnemius muscle in control and HFD groups after chronic CBD treatment.
<p>Representative Western blots showing the ratio of total expression of phosphorylated and unphosphorylated proteins involved in insulin signaling pathway e.g., phosphorylated insulin receptor substrate 1/insulin receptor substrate 1 - pIRS-1/IRS-1 (A), phosphorylated protein kinase B/protein kinase B - pAkt/Akt (B), phosphorylated AS160 protein/AS160 protein – pAS160/AS160 (C) and phosphorylated glycogen synthase kinase 3/glycogen synthase kinase 3 - pGSK-3/GSK-3 (D) in the red gastrocnemius muscle in control and HFD groups after chronic CBD treatment. The total expressions of the above proteins were presented as a percentage difference compared to the control group, which was set as 100%. The data are expressed as mean values ± SD, n = 6 in each group. ap < 0.05 significant difference: control group vs. examined group; bp < 0.05 significant difference: HFD vs. HFD+CBD.</p>
Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
ClinicalTrials.gov study NCT06387017. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Overexpression of IBIN (CG44404) using C564-GAL4 driver enhances a group of Toll pathway target genes and shows effects on metabolism
GEO Series GSE120437. Drosophila melanogaster. 18 samples. Type: Expression profiling by high throughput sequencing.
A virus-borne DNA damage signaling pathway controls the lysogeny-induction switch of a group of temperate pleolipoviruses
GEO Series GSE224586. Natrinema sp. J7-1. 11 samples. Type: Expression profiling by high throughput sequencing.
The cold-induced two-component system CBO0366/CBO0365 regulates metabolic pathways with novel roles in cold tolerance of Group I Clostridium botulinum ATCC 3502
GEO Series GSE26587. Clostridium botulinum A str. ATCC 3502. 6 samples. Type: Expression profiling by array.
Large-scale downregulation of cytokeratins in amniotic epithelium after Group B Streptococcus choriodecidual infection in Macaca nemestrina: a pathway to PPROM
GEO Series GSE46290. Macaca mulatta; Macaca nemestrina. 10 samples. Type: Expression profiling by array.
miR-4730 suppresses progression of hepatocellular carcinoma by targeting high mobility group A1 pathway
GEO Series GSE196261. Homo sapiens. 4 samples. Type: Expression profiling by array.
Ranking of nanomaterial potency to induce pathway perturbations associated with lung (Day 1, Group 1)
GEO Series GSE124037. Mus musculus. 35 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.