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1,200 results for “perfusion”
Resting State Perfusion in Healthy Aging
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Design of perfused PTFE vessel-like constructs for in vitro applications
<p>The design of a vessel-like construct for further use in perfused tissue models using PTFE membranes and collagen is presented. Endothelial cells were able to adhere to the tube’s wall, resisted perfusion, and formed an endothelial barrier delaying diffusion of fluorescently labeled molecules.</p>
Underlying data for "Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions"
<p>Underlying data for the paper "Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions" published in the journal <em>Bioengineering</em>.</p>
Perfusion experiment with 100uM fluorescein
<p>Control perfusion experiment with 100uM fluorescein, related to the manuscript titled: Polymodal sensory perception drives robust attachment and metamorphosis of a pre-vertebrate zooplanktonic larva. </p>
Flow in fetoplacental-like microvessels in vitro enhances perfusion, barrier function, and matrix stability
<p>Proper placental vascularization is vital for pregnancy outcomes, but assessing it with animal models and human explants has limitations. Here, we present a 3D in vitro model of human placenta terminal villi that includes fetal mesenchyme and vascular endothelium. By co-culturing HUVEC, placental fibroblasts, and pericytes in a macro-fluidic chip with a flow reservoir, we generate fully perfusable fetal microvessels. Pressure-driven flow is crucial for the growth and remodeling of these microvessels, resulting in early formation of interconnected placental-like vascular networks and maintained longevity. Computational fluid dynamics simulations predict shear forces, which increase microtissue stiffness, decrease diffusivity and enhance barrier function as shear stress rises. Mass-spec analysis reveals the deposition of numerous extracellular proteins, with flow notably enhancing the expression of matrix stability regulators, proteins associated with actin dynamics, and cytoskeleton organization. Our model provides a powerful tool for deducing complex in vivo parameters, such as shear stress on developing vascularized placental tissue, and holds promise for unraveling gestational disorders related to the vasculature.</p>
Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study
<p>This dataset contains primary data for DOI: 10.1002/nbm.4993</p> <p>NMR in Biomedicine. 2023; 10;e4993</p> <p>Title: Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study</p> <p>Authors: David Shaul, Naama Lev-Cohain, Gal Sapir, Jacob Sosna, J. Moshe Gomori, Leo Joskowicz, Rachel Katz-Brull</p> <p> </p> <p>Description:</p> <p>These primary datasets contains data presented in the above publication and consist of 31P- (at thermal equilibrium) and hyperpolarized 13C-NMR spectra. </p> <p>Please consult the Archive Guide.</p>
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function
We demonstrate that ischemia-reperfusion injury occurs in all livers during NMP, though there are notable differences in gene expression between functional and nonfunctional livers. We further demonstrate that activation of the liver's repair and homeostasis mechanisms through autophagy plays a vital role in the graft's response to injury and may impact liver function. These findings indicate that liver autophagy might be a key therapeutic target for rehabilitating the function of severely injured or untransplantable livers.
Raw Data for the article: The use of normothermic machine perfusion to rescue liver allografts from expanded criteria donors
<p>The use of expanded criteria donors is one of the strategies used to overcome the gap between the demand for organs and the number of donors. Physicians debate the extent to which marginal grafts can be used. In recent years, normothermic machine perfusion (NMP) has been used to test liver viability before transplantation. Grafts underwent NMP whenever histological steatosis was > 40% or there were at least three Eurotransplant criteria for expanded criteria donor (ECD). We used NMP to test 19 grafts, 3 from donation after type 3 controlled cardiac death (DCD), and 16 from donation after brain death (DBD). Only two grafts from DBD were not transplanted, because perfusion proved they were not suitable (total of 17 transplanted grafts of 19 tested grafts). Kaplan-Meier survival estimates at 30, 90, 180, and 1 year after transplant were all 94% (95% CI 84-100%); estimated 3-years survival was 82% (95% CI 62-100%). Overall survival rates did not differ from those of patients transplanted with non-perfused grafts from an ECD. In our experience, the use of very marginal grafts preventively tested by NMP does not negatively influence the patient's outcome, and increases the number of transplants in low donation areas.</p>
Characterization of NAD(P)H and FAD autofluorescence signatures in an isolated-perfused rat heart model
<p>Raw data concerning publication titled "Characterization of NAD(P)H and FAD autofluorescence signatures in an isolated-perfused rat heart model"</p> <p>Abstract</p> <p>Autofluorescence spectroscopy is a promising label-free approach to characterize biological samples with demonstrated potential to report structural and biochemical alterations in tissues in a number of clinical applications. We report a characterization of the ex vivo autofluorescence fingerprint of cardiac tissue, exploiting a Langendorff-perfused isolated rat heart model to induce physiological insults to the heart, with a view to understanding how metabolic alterations affect the autofluorescence signals. Changes in the autofluorescence intensity and lifetime signatures associated with reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and flavin adenine dinucleotide (FAD) were characterized during oxygen- or glucose-depletion protocols. Results suggest that both NAD(P)H and FAD autofluorescence intensity and lifetime parameters are sensitive to changes in the metabolic state of the heart owing to oxygen deprivation. We also observed changes in NAD(P)H fluorescence intensity and FAD lifetime parameter on reperfusion of oxygen, which might provide information on reperfusion injury, and permanent tissue damage or changes to the tissue during recovery from oxygen deprivation. We found that changes in the autofluorescence signature following glucose-depletion are, in general, less pronounced, and most clearly visible in NAD(P)H related parameters. Overall, the results reported in this investigation can serve as baseline for future investigations of cardiac tissue involving autofluorescence measurements.</p>
Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease
ClinicalTrials.gov study NCT00939822. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
ClinicalTrials.gov study NCT00239590. IPD Sharing: Not stated. Countries: 1. Publications: 1.
SGLT-2 Inhibitor and Myocardial Perfusion, Function and Metabolism in T2 DM Patients at High Cardiovascular Risk
ClinicalTrials.gov study NCT03151343. IPD Sharing: NO. Countries: 1. Publications: 25.
Myocardial Stress Perfusion Imaging With Dual Source CT
ClinicalTrials.gov study NCT00853671. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
ClinicalTrials.gov study NCT02589977. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Hepatocyte Growth Factor (HGF) Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia Patients With Peripheral Ischemic Ulcers
ClinicalTrials.gov study NCT00189540. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Positional Effects on Lung Ventilation and Perfusion in Obesity
ClinicalTrials.gov study NCT07341113. IPD Sharing: YES. Countries: 1. Publications: 1.
Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
ClinicalTrials.gov study NCT00826280. IPD Sharing: YES. Countries: 1. Publications: 1.
Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging
ClinicalTrials.gov study NCT01336140. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparative Study of Antegrade Versus Retrograde Cerebral Perfusion in Acute Type A Aortic Dissection: A Prospective Study
ClinicalTrials.gov study NCT06870513. IPD Sharing: NO. Countries: 1. Publications: 5.
Effect of Mental Stress on Myocardial Perfusion in Women
ClinicalTrials.gov study NCT03982901. IPD Sharing: YES. Countries: 1. Publications: 2.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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