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67 results for “photosensitizer”
Putative photosensitivity in internal light organs (organs of Pesta) of deep-sea sergestid shrimps
<p>Many marine species can regulate the intensity of bioluminescence from their ventral photophores in order to counterilluminate, a camouflage technique whereby animals closely match the intensity of the downwelling illumination blocked by their bodies, thereby hiding their silhouettes. Recent studies on autogenic cuticular photophores in deep-sea shrimps indicate that the photophores themselves are light-sensitive. Here, our results further suggest photosensitivity in a second type of autogenic photophore, the internal organs of Pesta, found in deep-sea sergestid shrimps. Experiments were conducted ship-board on live specimens, exposing the animals to bright light, which resulted in ultrastructural changes that matched those seen in crustacean eyes during the photoreceptor membrane turnover, a process that is crucial for the proper functioning of photosensitive components. In addition, RNA-seq studies demonstrated the expression of visual opsins and phototransduction genes in organs of Pesta tissue that are known to play a role in light detection, and electrophysiological measurements indicated that the light organs are responding to light received by the eyes. The long-sought-after mechanism of counterillumination remains unknown, but evidence of photosensitivity in photophores may indicate a dual functionality of light detection and emission.</p>
Nonlinear imaging microscopy for assessing structural and photochemical modifications upon laser removal of dammar varnish on photosensitive substrates
<p>Varnish layers are commonly used to protect painted surfaces from atmospheric pollution, oxidation<br> and improve the aesthetic appearance of the artwork by providing an even surface finish, brilliance and<br> depth to the colours. However, the outer varnish layers suffer from progressive deterioration due to<br> aging and the continuous exposure to aggressive environmental conditions, imposing the need of their<br> removal for rectifying the optical and aesthetic properties of the painting and extend its lifetime. The<br> removal of the surface varnish layer, without affecting the painting substrate, comprises a delicate<br> intervention in cultural heritage (CH) conservation.<br> The main objective of this study is to determine by nonlinear imaging microscopy (NLM) the extent of<br> the photochemical damage that could be induced on underlying painting layers by laser removal of<br> varnish protective coatings. This will lead to the identification of the optimal laser cleaning conditions<br> that produce the minimum collateral damage to the painting layers.<br> The current study is undertaken using model samples constituted by bilayers, where the top varnish<br> layer (dammar) coats a bottom layer constituted by a doped synthetic polymer (polymetilmetacrilate,<br> PMMA doped with POPUP) film, the latter mimicking a paint layer. The target is to determine the<br> affected region as a function of depth of the doped polymer layer induced by laser ablation of the<br> varnish. To this aim we use the non destructive NLM imaging modalities of third harmonic generation<br> (THG) and multiphoton excitation fluorescence (MPEF) as novel diagnostic tools and a number of<br> laser conditions for varnish removal, namely different ultraviolet (UV) wavelengths and pulse durations.<br> Characterization of the samples by NLM is complemented by spectroscopic micro-Raman and laser<br> induced fluorescence (one-photon excitation) measurements. These provide a full characterization of<br> the lateral and in-depth chemical and morphological changes following laser removal of the varnish<br> protective layer.</p>
Nonlinear imaging microscopy for assessing structural and photochemical modifications upon laser removal of dammar varnish on photosensitive substrates
<p>The nonlinear optical microscopy (NLM) modalities of Multi-Photon Excited Fluorescence (MPEF) and Third Harmonic Generation (THG) have been combined in this work to characterize as a function of depth with micrometric resolution the type and extent of morphological and photochemical modifications that take place upon ultraviolet (UV) pulsed laser removal of a dammar varnish layer applied on a photosensitive substrate. The latter consists on a layer of the synthetic polymer polymethyl methacrylate doped with a photosensitizer, the aromatic compound 1,4-di[2-(5-phenyloxazolyl)] benzene, that strongly fluoresces upon UV light illumination. A number of laser conditions for partial or total elimination of the varnish coating were explored, namely different wavelengths (266, 248 and 213 nm) and pulse durations, in the nanosecond, picosecond and femtosecond ranges. Changes in the MPEF signals upon laser ablation of the outermost varnish layer successfully signpost photochemical modifications of the varnish or of the photosensitive under-layer, and their dependence with the laser ablation parameters, i.e., wavelength and pulse duration. In turn, THG signals mark the presence of layer boundaries and the reduction by laser ablation of the thickness of the varnish coating. The obtained MPEF and THG data are complemented by morphological observation by optical microscopy and measurements of laser induced fluorescence and micro-Raman spectra of the samples before and after laser ablation at the selected laser irradiation conditions. The results acquired through these nondestructive NLM imaging techniques serve to understand the phenomena that are induced upon laser ablation and to determine the best operating conditions that ensure controlled removal of the varnish with minimal morphological and chemical modifications to the under-layers. This research is of direct application to the UV pulsed laser cleaning of paintings and demonstrates the potential of NLM as a novel assessment tool for non-destructive, on line monitoring of the laser cleaning process.</p>
Dataset related to article "Successful use of perampanel in GABRA1-related myoclonic epilepsy with photosensitivity Epilepsy"
<p>Sequencing analyses performed at Fondazione Besta and carried out as part of the study mentioned at title</p>
Putative photosensitivity in internal light organs (organs of Pesta) of deep-sea sergestid shrimps
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Geometries of Mo-Isocyanide Photosensitizers
<p>Geometries retrieved by the means of DFT and TD-DFT (excited state tracking) of the compounds discussed in our recent work "Deep-Red Luminescent Molybdenum(0) Complexes with Bi- and Tridentate Isocyanide Chelate Ligands".</p>
Light organ photosensitivity in deep-sea shrimp may suggest a novel role in counterillumination
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Quantum Chemical Data – A Heterodox Approach for Designing Iron Photosensitizers: Pentacyanoferrate Complexes with Monodentate Pyridinium based Acceptor Ligands
<p>Simulated ground and excited state properties of <strong>[</strong><strong>Fe-mpz<sup>+</sup>]</strong><strong> </strong>and <strong>[Fe-bpy<sup>+</sup>]</strong>, as obtained at the B3LYP/def2svp level of theory within water (PCM vs PCM and 10 explicit water molecules). Both complexes were investigated within Franck-Condon region (see directory: FC) as well as within two triplet equilibria (see directories: 3mc and 3mlct).</p> <p>The folder of each system contains the charge density differences (CDDs) of dipole-allowed transitions contributing to the electronic absorption within the singlet ground state (singlet-singlet transitions: SS and singlet-triplet transitions: ST).</p> <p>The spin density of the relaxed triplet ground state (see directories: 3mc and 3mlct) and CDDs of spin and dipole allowed triplet-triplet transitions are given. These transitions are correlated to the excited-state absorption signals as investigated by transient absorption spectroscopy.</p> <p>All fully relaxed equilibrium structures, i.e., S<sub>0</sub> (FC) and T<sub>1</sub> (<sup>3</sup>MC and <sup>3</sup>MLCT) as well as (approximate) transition state strutures along the <sup>3</sup>MLCT-<sup>3</sup>MC pathways are provided as xyz files within the respective folders.</p>
The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
ClinicalTrials.gov study NCT01942564. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study)
ClinicalTrials.gov study NCT04654312. IPD Sharing: NO. Countries: 1. Publications: 1.
Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL)
ClinicalTrials.gov study NCT02464709. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PF-06372865 in Subjects With Photosensitive Epilepsy
ClinicalTrials.gov study NCT02564029. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Photosensitivity of the Skin Under Azathioprin in Renal Transplant Recipients
ClinicalTrials.gov study NCT00492895. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of BGG492 on EEG in Patients With Photosensitive Epilepsy
ClinicalTrials.gov study NCT00784212. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of YKP3089 in Patients With Photosensitive Epilepsy
ClinicalTrials.gov study NCT00616148. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The photosensitive phase acts as a sensitive window for seasonal multisensory neuroplasticity in male and female starlings
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Reproducible determination of dissolved organic matter photosensitivity: Data and code
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Data from: Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity
Background: Phosphodiesterase 6 (PDE6) is a protein complex that hydrolyses cGMP and acts as the effector of the vertebrate phototransduction cascade. The PDE6 holoenzyme consists of catalytic and inhibitory subunits belonging to two unrelated gene families. Rods and cones express distinct genes from both families: PDE6A and PDE6B code for the catalytic and PDE6G the inhibitory subunits in rods while PDE6C codes for the catalytic and PDE6H the inhibitory subunits in cones. We performed phylogenetic and comparative synteny analyses for both gene families in genomes from a broad range of animals. Furthermore, gene expression was investigated in zebrafish. Results: We found that both gene families expanded from one to three members in the two rounds of genome doubling (2R) that occurred at the base of vertebrate evolution. The PDE6 inhibitory subunit gene family appears to be unique to vertebrates and expanded further after the teleost-specific genome doubling (3R). We also describe a new family member that originated in 2R and has been lost in amniotes, which we have named pde6i. Zebrafish has retained two additional copies of the PDE6 inhibitory subunit genes after 3R that are highly conserved, have high amino acid sequence identity, are coexpressed in the same photoreceptor type as their amniote orthologs and, interestingly, show strikingly different daily oscillation in gene expression levels. Conclusions: Together, these data suggest specialisation related to the adaptation to different light intensities during the day-night cycle, most likely maintaining the regulatory function of the PDE inhibitory subunits in the phototransduction cascade.
Data from: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are involved in circadian and other non-image forming visual responses. An open question is whether the activity of these neurons may also be under the regulation mediated by the neurohormone melatonin. In the present work, by double-staining immunohistochemical technique, we studied the expression of MT1 and MT2, two known subtypes of mammalian melatonin receptors, in rat ipRGCs. A single subset of retinal ganglion cells labeled by the specific antibody against melanopsin exhibited the morphology typical of M1-type ipRGCs. Immunoreactivity for both MT1 and MT2 receptors was clearly seen in the cytoplasm of all labeled ipRGCs, indicating that these two receptors were co-expressed in each of these neurons. Furthermore, labeling for both the receptors were found in neonatal M1 cells as early as the day of birth. It is therefore highly plausible that retinal melatonin may directly modulate the activity of ipRGCs, thus regulating non-image forming visual functions.
Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, accepted for publication in Scientifc Reports, entitled:</strong></p> <p><strong>Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.</strong></p> <p><strong>Authored by:</strong></p> <p>Elin Sandberg <sup>1</sup>, Chinmaya V Srambickal <sup>1</sup>, Joachim Piguet <sup>1</sup>, Haichun Liu <sup>1</sup> and Jerker Widengren <sup>1,</sup>*</p> <p><sup>1</sup> Experimental Biomolecular Physics, Department of Applied Physics, Royal Institute of Technology (KTH), Stockholm, Sweden</p> <p><sup>* </sup>To whom correspondence should be addressed. Email: jwideng@kth.se. Tel: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped with respect to the figures/tables in the manuscript where the extracted results are presented. </strong></p> <p><strong>ABSTRACT</strong></p> <p>Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states. Monitoring these states <em>in situ</em> can provide important feedback but is difficult in practice. The states are strongly influenced by local oxygenation, pH and redox conditions, often varying significantly at PDT treatment sites. To overcome this problem, we followed local PDT precursor state populations of PS compounds, via their fluorescence intensity response to systematically varied excitation light modulation. Thereby, we could demonstrate local monitoring of PDT precursor states of methylene blue (MB) and IRdye700DX (IR700), and determined their transitions rates under different oxygenation, pH and redox conditions. By fiber-optics, using one fiber for both excitation and fluorescence detection, the triplet and photo-radical state kinetics of locally applied MB and IR700 could then be monitored in a tissue sample. Finally, potassium iodide and ascorbate were added as possible PDT adjuvants, enhancing intersystem crossing and photoreduction, respectively, and their effects on the PDT precursor states of MB and IR700 could be locally monitored. Taken together, the presented procedure overcomes current methodological limitations and can offer feedback, guiding both excitation and PDT adjuvant application, and thereby more efficient and targeted PDT treatments.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.