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13 results for “phylogenetic robustness”
Data from: Scoutknife: A naïve, whole genome informed phylogenetic robusticity metric
<p>The phylogenetic bootstrap, first proposed by Felsenstein in 1985, is a critically important statistical method in assessing the robusticity of phylogenetic datasets. Core to its concept was the use of pseudosampling - assessing the data by generating new replicates derived from the initial dataset that was used to generate the phylogeny. In this way, phylogenetic support metrics could overcome the lack of perfect, infinite data. With infinite data, however, it is possible to sample smaller replicates directly from the data to obtain both the phylogeny and its statistical robusticity in the same analysis. Due to the growth of whole genome sequencing, the depth and breadth of our datasets have greatly expanded and are set to only expand further. With genome-scale datasets comprising thousands of genes, we can now obtain a proxy for infinite data. Accordingly, we can potentially abandon the notion of pseudosampling and instead randomly sample small subsets of genes from the thousands of genes in our analyses. Here, we introduce Scoutknife, a jackknife-style subsampling implementation that generates 100 datasets by randomly sampling a small number of genes from an initial large-gene dataset to jointly establish both a phylogenetic hypothesis and assess its robusticity. Using 18 previously published datasets and 100 simulation studies, we show that Scoutknife is conservative and informative as to conflicts and incongruence across the whole genome, without the need for subsampling based on traditional model selection criteria.</p>
Data from: Scoutknife: A naïve, whole genome informed phylogenetic robusticity metric
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Data from: Quartet-based computations of internode certainty provide robust measures of phylogenetic incongruence
Incongruence, or topological conflict, is prevalent in genome-scale data sets. Internode Certainty (IC) and related measures were recently introduced to explicitly quantify the level of incongruence of a given internal branch among a set of phylogenetic trees and complement regular branch support measures (e.g., bootstrap, posterior probability) that instead assess the statistical confidence of inference. Since most phylogenomic studies contain data partitions (e.g., genes) with missing taxa and IC scores stem from the frequencies of bipartitions (or splits) on a set of trees, IC score calculation typically requires adjusting the frequencies of bipartitions from these partial gene trees. However, when the proportion of missing taxa is high, the scores yielded by current approaches that adjust bipartition frequencies in partial gene trees differ substantially from each other and tend to be overestimates. To overcome these issues, we developed three new IC measures based on the frequencies of quartets, which naturally apply to both complete and partial trees. Comparison of our new quartet-based measures to previous bipartition-based measures on simulated data shows that: 1) on complete data sets, both quartet-based and bipartition-based measures yield very similar IC scores; 2) IC scores of quartet-based measures on a given data set with and without missing taxa are more similar than the scores of bipartition-based measures; and 3) quartet-based measures are more robust to the absence of phylogenetic signal and errors in phylogenetic inference than bipartition-based measures. Additionally, the analysis of an empirical mammalian phylogenomic data set using our quartet-based measures reveals the presence of substantial levels of incongruence for numerous internal branches. An efficient open-source implementation of these quartet-based measures is freely available in the program QuartetScores (https://github.com/lutteropp/QuartetScores).
Robust analysis of phylogenetic tree space
<p>Phylogenetic analyses often produce large numbers of trees. Mapping trees' distribution in "tree space" can illuminate the behavior and performance of search strategies, reveal distinct clusters of optimal trees, and expose differences between different data sources or phylogenetic methods—but the high-dimensional spaces defined by metric distances are necessarily distorted when represented in fewer dimensions. Here, I explore the consequences of this transformation in phylogenetic search results from 128 morphological data sets, using stratigraphic congruence—a complementary aspect of tree similarity—to evaluate the utility of low-dimensional mappings. I find that phylogenetic similarities between cladograms are most accurately depicted in tree spaces derived from information-theoretic tree distances or the quartet distance. Robinson–Foulds tree spaces exhibit prominent distortions and often fail to group trees according to phylogenetic similarity, whereas the strong influence of tree shape on the Kendall–Colijn distance makes its tree space unsuitable for many purposes. Distances mapped into two or even three dimensions often display little correspondence with true distances, which can lead to profound misrepresentation of clustering structure. Without explicit testing, one cannot be confident that a tree space mapping faithfully represents the true distribution of trees, nor that visually evident structure is valid. My recommendations for tree space validation and visualization are implemented in a new graphical user interface in the "TreeDist" R package.</p>
Quartet-based computations of internode certainty provide robust measures of phylogenetic incongruence
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Data from: Advancing Pyrus phylogeny: Deep genome skimming-based inference coupled with paralogy analysis yields a robust phylogenetic backbone and an updated infrageneric classification of the pear genus (Maleae, Rosaceae)
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Robust analysis of phylogenetic tree space
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Nesokia is sister to Bandicota and are nested in Rattus phylogenetically, making Rat- tus paraphyletic. Tarsomys, Limnomys, and Diplothrix are also phylogenetically in Rat- tus, and the clade is in need of focused re- vision at the generic level. Nesokia bunnui was originally described as a separate ge-nus, Erythronesokia, because it is morphologically very distinctive from N. indica. Type specimen was destroyed during the Iraq War, and a neotype was recently designated to replace it. Monotypic. Distribution. Tigris and Euphrates river valleys, SE Iraq. Descriptive notes. Head—body 230-260 mm, tail 205-270 mm, ear 18-21 mm, hindfoot 49-58 mm; weight 519 g. The Long-tailed Bandicoot Rat is larger than the Short-tailed Bandicoot Rat (N. indica). Pelage is soft and woolly, interspersed with harsher coarse hair and long black hairs near mid-back. Dorsum is fawn to ocherous red, washed with purple or chestnuton darker individuals. Hairs are basally slate-gray and distally rufous, occasionally with whitish or black tips. Muzzle is drab. Sides arefawn, with gray edge toward venter. Venteris whitish, extending onto cheeks where the same pattern from gray to fawn to dorsal pelage occurs. Feet are large and robust, being light brown and well-furred dorsally. Claws are amber on forefeet and dull brown on hindfeet; pollux is extremely small. Ears are moderately long and brownish, with no hair internally. Tail is ¢.82-104% of head-body length and deep brownish drab, interspersed with visible white hair. Skull is large and robust, similarly to the Short-tailed Bandicoot Rat. Habitat. Marsh and swamp land. Food and Feeding. No information. Breeding. No information. Activity patterns. The Long-tailed Bandicoot Rat is terrestrial, although it isfound in swampy and marshy areas and is probably amphibious. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Endangered on The IUCN Red List. The Longtailed Bandicoot Rat is apparently rare and is known from very few specimens. Marsh and swamp habitats in which it is found were completely destroyed during the Iraq War by draining, war damage, and agricultural expansion. In recent years, flooding from Tigris and Euphrates rivers and high snow fall and melt haveresulted in partial restoration ofits native habitat, although restoration is not a complete. Populations are now probably highly fragmented. Bibliography. Al-Ansari et al. (2012), Al-Robaae & Felten (1990), Khajuria (1981), Krystufek et al. (2017), Musser & Carleton (2005), Richardson & Hussain (2006), Stuart (2008). in Muridae
Nesokia is sister to Bandicota and are nested in Rattus phylogenetically, making Rat- tus paraphyletic. Tarsomys, Limnomys, and Diplothrix are also phylogenetically in Rat- tus, and the clade is in need of focused re- vision at the generic level. Nesokia bunnui was originally described as a separate ge-nus, Erythronesokia, because it is morphologically very distinctive from N. indica. Type specimen was destroyed during the Iraq War, and a neotype was recently designated to replace it. Monotypic. Distribution. Tigris and Euphrates river valleys, SE Iraq. Descriptive notes. Head—body 230-260 mm, tail 205-270 mm, ear 18-21 mm, hindfoot 49-58 mm; weight 519 g. The Long-tailed Bandicoot Rat is larger than the Short-tailed Bandicoot Rat (N. indica). Pelage is soft and woolly, interspersed with harsher coarse hair and long black hairs near mid-back. Dorsum is fawn to ocherous red, washed with purple or chestnuton darker individuals. Hairs are basally slate-gray and distally rufous, occasionally with whitish or black tips. Muzzle is drab. Sides arefawn, with gray edge toward venter. Venteris whitish, extending onto cheeks where the same pattern from gray to fawn to dorsal pelage occurs. Feet are large and robust, being light brown and well-furred dorsally. Claws are amber on forefeet and dull brown on hindfeet; pollux is extremely small. Ears are moderately long and brownish, with no hair internally. Tail is ¢.82-104% of head-body length and deep brownish drab, interspersed with visible white hair. Skull is large and robust, similarly to the Short-tailed Bandicoot Rat. Habitat. Marsh and swamp land. Food and Feeding. No information. Breeding. No information. Activity patterns. The Long-tailed Bandicoot Rat is terrestrial, although it isfound in swampy and marshy areas and is probably amphibious. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Endangered on The IUCN Red List. The Longtailed Bandicoot Rat is apparently rare and is known from very few specimens. Marsh and swamp habitats in which it is found were completely destroyed during the Iraq War by draining, war damage, and agricultural expansion. In recent years, flooding from Tigris and Euphrates rivers and high snow fall and melt haveresulted in partial restoration ofits native habitat, although restoration is not a complete. Populations are now probably highly fragmented. Bibliography. Al-Ansari et al. (2012), Al-Robaae & Felten (1990), Khajuria (1981), Krystufek et al. (2017), Musser & Carleton (2005), Richardson & Hussain (2006), Stuart (2008).
Phylogenetic diversity rankings in the face of extinctions: The robustness of the fair proportion index
<p>Planning for the protection of species often involves difficult choices about which species to prioritize, given constrained resources.<br> One way of prioritizing species is to consider their "evolutionary distinctiveness'', i.e. their relative evolutionary isolation on a phylogenetic tree. Several evolutionary isolation metrics or phylogenetic diversity indices have been introduced in the literature, among them the so-called Fair Proportion index (also known as the "evolutionary distinctiveness" score). This index apportions the total diversity of a tree among all leaves, thereby providing a simple prioritization criterion for conservation. </p> <p>Here, we focus on the prioritization order obtained from the Fair Proportion index and analyze the effects of species extinction on this ranking. More precisely, we analyze the extent to which the ranking order may change when some species go extinct and the Fair Proportion index is re-computed for the remaining taxa. We show that for each phylogenetic tree, there are edge lengths such that the extinction of one leaf per cherry completely reverses the ranking. Moreover, we show that even if only the lowest ranked species goes extinct, the ranking order may drastically change. <br> We end by analyzing the effects of these two extinction scenarios (extinction of the lowest ranked species and extinction of one leaf per cherry) for a collection of empirical and simulated trees. In both cases, we can observe significant changes in the prioritization orders, highlighting the empirical relevance of our theoretical findings.</p>
Phylogenetic diversity rankings in the face of extinctions: The robustness of the fair proportion index
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Data from: Effects of phylogenetic reconstruction method on the robustness of species delimitation using single-locus data
1. Coalescent-based species delimitation methods combine population genetic and phylogenetic theory to provide an objective means for delineating evolutionarily significant units of diversity. The Generalized Mixed Yule Coalescent (GMYC) and the Poisson Tree Process (PTP) are methods that use ultrametric (GMYC or PTP) or non-ultrametric (PTP) gene trees as input, intended for use mostly with single-locus data such as DNA barcodes. 2. Here we assess how robust the GMYC and PTP are to different phylogenetic reconstruction and branch smoothing methods. We reconstruct over 400 ultrametric trees using up to 30 different combinations of phylogenetic and smoothing methods and perform over 2,000 separate species delimitation analyses across 16 empirical datasets. We then assess how variable diversity estimates are, in terms of richness and identity, with respect to species delimitation, phylogenetic and smoothing methods. 3. The PTP method generally generates diversity estimates that are more robust to different phylogenetic methods. The GMYC is more sensitive, but provides consistent estimates for BEAST trees. The lower consistency of GMYC estimates is likely a result of differences among gene trees introduced by the smoothing step. Unresolved nodes (real anomalies or methodological artefacts) affect both GMYC and PTP estimates, but have a greater effect on GMYC estimates. Branch smoothing is a difficult step and perhaps an underappreciated source of bias that may be widespread among studies of diversity and diversification. 4. Nevertheless, careful choice of phylogenetic method does produce equivalent PTP and GMYC diversity estimates. We recommend simultaneous use of the PTP model with any model-based gene tree (e.g. RAxML) and GMYC approaches with BEAST trees for obtaining species hypotheses.
Data from: Effects of phylogenetic reconstruction method on the robustness of species delimitation using single-locus data
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Extensive phylogenetic analysis of Piscine orthoreovirus genomic sequences shows the robustness of subgenotype classification
<p><strong>Figure 1.</strong> Circular dendogram of S1 PRV genomic segment. The phylogenetic analysis was performed using sequences with at least 400 nucleotides. New and unknown subgenotype sequences were assigned according to their positions in the dendogram branches.</p> <p><strong>Figure 2.</strong> Phylogenetic tree of PRV M2 genomic segment. The dendogram was built utilizing sequences with at least 1000 nucleotides. New and unknown subgenotype sequences were assigned according to their positions in the dendogram branches.</p> <p><strong>Figure 3.</strong> Phylogenetic distance heatmap for 40 M2 sequences, including new sequences produced for this study. The colors represent the subgenotype and the distance matrix value.</p> <p><strong>Figure 4.</strong> Phylogenetic distance heatmap obtained from the alignment of 61 S1 sequences, including new sequences produced for this study. The colors represent the subgenotype and the distance matrix value.</p> <p><strong>Figure 5.</strong> Phylogenetic distances from the alignment of S1 sequences in Figure 4 by country represented as heatmaps.</p> <p><strong>Figure 6.</strong> Phylogenetic distances from the alignment of S1 sequences in Figure 4 by host species represented as heatmaps.</p>
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International Brain Laboratory public data
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OpenNeuro
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