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12 results for “phytocannabinoids”
Fig. 4 in Insights on the antiradical capacity and mechanism of phytocannabinoids: H-abstraction and electron transfer processes in physiological media and the influence of the acid-base equilibrium
Fig. 4. Gibbs free energies of the HOO• scavenging reaction of phytocannabinoids under physiological conditions.
Fig. 5 in Insights on the antiradical capacity and mechanism of phytocannabinoids: H-abstraction and electron transfer processes in physiological media and the influence of the acid-base equilibrium
Fig. 5. Localized TSs for fHAT mechanism of phytocannabinoids in the lipid-like environment. The Distances are in A.
Fig. 1 in Biosynthetic origins of unusual cannabimimetic phytocannabinoids in Cannabis sativa L: A review
Fig. 1. Topological arrangement and structural relationships of alkyl phytocannabinoids. (a) Alkyl phytocannabinoid isoprenyl subclasses and biosynthetic relationships. (b) Major pharmacophore and common structural features between the phytocannabinoid Δ 9-THC and the endocannabinoid anandamide (N-arachidonoylethanolamine; AEA).Compound subclass abbreviations: CBC - cannabichromene; CBD - cannabidiol; CBE - cannabielsoin; CBF - cannabifuran; CBG - cannabigerol; CBL - cannabicyclol; CBN - cannabinol; CBND - cannabinodiol; THC – Δ9 tetrahydrocannabinol; red colour phytocannabinoid moieties derived from a = resorcinol origin, blue colour = phytocannabinoid moieties derived from an isoprenoid origin. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3 in Biosynthetic origins of unusual cannabimimetic phytocannabinoids in Cannabis sativa L: A review
Fig. 3. Schematic diagram of phytocannabinoid biosynthesis and precursor pathways. Grey arrows and text indicate putative precursor pathways and enzymes associated with recently reported in planta phytocannabinoid analogues. Coloured arrows and text indicate known biosynthetic pathways leading to the production of phytocannabinoids. Blue arrows and text indicate the methylerythritol phosphate pathway leading to the production of the isoprenoid intermediate geranyl diphosphate used in both monoterpenoid and phytocannabinoid biosynthesis. Red arrows and text indicate the alkylresorcinolic acid pathway leading to the production of the phytocannabinoid intermediate olivetolic acid. Green arrows and text indicate the phytocannabinoid pathway and enzymes leading to the production of monocyclic, dicyclic and tricyclic alkyl phytocannabinoids. Numbers in parentheses indicate compound numbers from Table 1 and their positions indicate putative branch points associated with phytocannabinoid analogue production. Question marks indicate uncertainty over either the transportation of metabolites between subcellular compartments or the catalytic mechanism leading to the biosynthesis of phytocannabinoid metabolites. Biochemical pathway abbreviations: AACT - acetyl-CoA C-acyltransferase (EC 2.3.1.16); ACCase - acetyl-CoA carboxylase (EC 6.4.1.2); ACP - acyl carrier protein; CBC - cannabichromene; CBCAS - cannabichromenic acid synthase; CBD - cannabidiol; CBDAS - cannabidiolic acid synthase (EC:1.21.3.8); CBG - cannabigerol; CMK - 4-(Cytidine 5′-diphospho)-2-C-methyl-Derythritol kinase (EC 2.7.1.148); CoA - coenzyme A; CsAAE1 - acyl-activating enzyme 1; CsOAC - olivetolic acid cyclase (EC:4.4.1.26); CsPT1 - geranylpyrophosphate: olivetolate geranyltransferase (EC 2.5.1.102); CsTKS - tetraketide synthase (EC:2.3.1.206); DMAPP - dimethylallyl diphosphate; DXR - 1-deoxy-D-xylulose-5-phosphate reductoisomerase (EC 1.1.1.267); DXS - 1-deoxy-D-xylulose 5 phosphate synthase (EC 2.2.1.7); ENR - enoyl-ACP reductase; FAD - fatty acid desaturase; FPPS - farnesyl pyrophosphate synthase (EC 2.5.1.10); G3P - glyceraldehyde 3-phosphate; GPPS - geranyl diphosphate synthase (EC:2.5.1.1); HD - 3-hydroxyacyl-ACP dehydratase; HDR - 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate reductase (EC:1.17.7.4); HDS - 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate synthase (EC 1.17.7.3); HMGR - hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34); HMGS - hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10); HPL - hydroperoxide lyase (EC:4.1.2.-); IPP - isopentenyl diphosphate; KAR - 3-ketoacyl-ACP reductase; KAS - β-ketoacyl-ACP synthase; LOX2 - 13S-lipoxygenase 2 (EC:1.13.11.12); MAT - malonyl-CoA: acyl carrier protein malonyltransferase (EC 2.3.1.39); MCT - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60); MDS - 2-Cmethyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12); MEP - methylerythritol phosphate; MK - mevalonate kinase (EC 2.7.1.36); MVA - mevalonate; OPP - diphosphate; PMK - phosphomevalonate kinase (EC 2.7.4.2); PPMD - diphosphomevalonate decarboxylase (EC 4.1.1.33); SCD - stearoyl-CoA desaturase (Delta- 9 desaturase) (EC:1.14.19.1); THC - Δ9 tetrahydrocannabinol; THCAS – Δ9 tetrahydrocannabinolic acid synthase (EC:1.21.3.7); 13(S)-HPODE - 13S-hydroperoxy- 9Z,11E-octadecadienoic acid. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 in Biosynthetic origins of unusual cannabimimetic phytocannabinoids in Cannabis sativa L: A review
Fig. 2. Summary of Cannabis sativa L. trichome morphotypes: (a) Non-glandular trichome on the adaxial surface of a floral bract. (b) Glandular trichomes on the adaxial surface of a vegetative leaf. (c) capitate stalked glandular trichome on the abaxial surface of a floral bract. (d) Approximate location of capitate stalked glandular trichome cell types and substructures, scale bar = 100 μm.
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
ClinicalTrials.gov study NCT06842316. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Fig. 3 in Insights on the antiradical capacity and mechanism of phytocannabinoids: H-abstraction and electron transfer processes in physiological media and the influence of the acid-base equilibrium
Fig. 3. Acid-base equilibrium of phytocannabinoids in water at physiological pH (7.4).
Fig. 1 in Insights on the antiradical capacity and mechanism of phytocannabinoids: H-abstraction and electron transfer processes in physiological media and the influence of the acid-base equilibrium
Fig. 1. Molecular structure and atomic numbering of the investigated phytocannabinoids.
Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
ClinicalTrials.gov study NCT05672342. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
ClinicalTrials.gov study NCT06731894. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phytocannabinoids reduce inflammation of primed macrophages and enteric glial cells Critical review of the effect of phytocannabinoids on gut immune cells
GEO Series GSE240225. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
Fig. 2 in Insights on the antiradical capacity and mechanism of phytocannabinoids: H-abstraction and electron transfer processes in physiological media and the influence of the acid-base equilibrium
Fig. 2. Energy and distribution of HOMOs and LUMOs of phytocannabinoids.
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