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10 results for “post-acute sequelae of SARS-CoV-2 infection”
Fat oxidation rates and cardiorespiratory responses during exercise in different subject populations with post-acute sequelae of SARS-CoV-2 infection: a comparison with normative percentile values
<p>INTRODUCTION: Post-acute sequelae of SARS-CoV-2 infection (PASC) presents a spectrum of symptoms following acute COVID-19, with exercise intolerance being a prevalent manifestation likely linked to disrupted oxygen metabolism and mitochondrial function. This study aims to assess maximal fat oxidation (MFO) and exercise intensity at MFO (FATmax) in distinct PASC subject groups and compare these findings with normative data.</p> <p>METHODS: Eight male subjects with PASC were involved in this study. The participants were divided in two groups: “endurance-trained” subjects (V̇O<sub>2</sub>max > 55 ml/min/kg) and “recreationally-active” subjects (V̇O<sub>2</sub>max < 55 ml/min/kg). Each subject performed a graded exercise test until maximal oxygen consumption (V̇O<sub>2</sub>max) to measure fat oxidation. Subsequently, MFO was assessed and FATmax calculated as the ratio between V̇O<sub>2 </sub>at MFO and V̇O<sub>2</sub>max.</p> <p>RESULTS: The MFO and FATmax of “endurance-trained” subjects were 0.85, 0.89, 0.71 and 0.42, and 68%, 69%, 64% and 53%, respectively. Three out of four subjects showed both MFO and FATmax values placed over the 80<sup>th</sup> percentile of normative data. The MFO and FATmax of “recreationally-active” subjects were 0.34, 0.27, 0.35 and 0.38, and 47%, 39%, 43% and 41%, respectively. All MFO and FATmax values of those subjects placed below the 20<sup>th</sup> percentile or between the 20<sup>th</sup> and 40<sup>th</sup> percentile.</p> <p>DISCUSSION: Significant differences in MFO and FATmax values between 'endurance-trained' and “recreationally-active” subjects suggest that specific endurance training, rather than simply an active lifestyle, may provide protective effects against alterations in mitochondrial function during exercise in subjects with PASC.</p>
(CBDRA60) to Prevent or Reduce Symptoms of COVID-19 and Prevention of Post-Acute Sequelae of SARS-CoV-2 Infection PASC
ClinicalTrials.gov study NCT04777981. IPD Sharing: NO. Countries: 1. Publications: 22.
A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection
ClinicalTrials.gov study NCT05472090. IPD Sharing: NO. Countries: 1. Publications: 0.
Macrophage peroxisomes guide alveolar regeneration and limit post-acute sequelae of SARS-CoV-2 infection (PASC)
GEO Series GSE280545. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Exercise in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study
ClinicalTrials.gov study NCT05218174. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction
ClinicalTrials.gov study NCT06597682. IPD Sharing: NO. Countries: 1. Publications: 0.
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
ClinicalTrials.gov study NCT05866952. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
ClinicalTrials.gov study NCT06920628. IPD Sharing: YES. Countries: 1. Publications: 0.
Covid-19, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Influenza Treatment System With Machine Learning
ClinicalTrials.gov study NCT06052527. IPD Sharing: NO. Countries: 1. Publications: 0.
Macrophage peroxisomes guide alveolar regeneration and limit post-acute sequelae of SARS-CoV-2 infection (PASC).
GEO Series GSE281262. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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