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Dataset results
11 results for “prescribing behaviors”
Drugs prescribed in Phelan-McDermid Syndrome differentially impact sensory behaviors in shank3 zebrafish models
<p>Altered sensory processing is a pervasive symptom in individuals with Autism Spectrum Disorders (ASD). Especially in cases of profound autism, individuals are often medicated to manage behaviors like aggression and/or self-harm and/or epilepsy, and it remains unclear how these medications might impact perception/sensory processing. To test this, we screened three medications, risperidone, Lithium Chloride (LiCl), and carbamazepine (CBZ), prescribed to individuals with Phelan-McDermid Syndrome (PMS) and one drug, 2-Methyl-6-(phenylethynyl) pyridine (MPEP) tested in rodent models of PMS, for their effects on a sensory-induced behavior in two zebrafish PMS models with frameshift mutations in the N- or C- termini. PMS is caused by deletions of the terminal end of chromosome 22 or point mutations in <em>Shank3</em>. People with PMS can present with an array of symptoms including ASD, epilepsy, gastrointestinal distress, and reduced responses to sensory stimuli. Our zebrafish mutant shank3ab models likewise show reduced responses in a Visual Motor Response (VMR) assay, in which increased locomotion is triggered by light-to-dark transitions. To test how pharmacological treatments affect the VMR, we exposed larvae to selected drugs for twenty-four hours and then quantified their locomotion during four ten-minute cycles of lights on-to-off stimuli. We found that risperidone normalized the VMR in <em>shank3</em> models, LiCl and CBZ had no effect on the VMR in any of the three genotypes. MPEP reduced the VMR in WT to levels seen in <em>shank3</em> models but caused no changes in either <em>shank3</em> model. Our work shows that the effects of drugs on sensory processing is varied in a way that can be highly genotype- and drug-dependent.</p>
Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
ClinicalTrials.gov study NCT04284553. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Drugs prescribed in Phelan-McDermid Syndrome differentially impact sensory behaviors in shank3 zebrafish models
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INcreasing Statin Prescribing in HIV Behavioral Economics REsearch
ClinicalTrials.gov study NCT03687060. IPD Sharing: NO. Countries: 1. Publications: 19.
Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care
ClinicalTrials.gov study NCT03537573. IPD Sharing: NO. Countries: 1. Publications: 1.
Behavioral Insights to Encourage Judicious Prescribing of Opioids
ClinicalTrials.gov study NCT02790476. IPD Sharing: NO. Countries: 1. Publications: 0.
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
ClinicalTrials.gov study NCT05182606. IPD Sharing: NO. Countries: 1. Publications: 0.
Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire
ClinicalTrials.gov study NCT04820062. IPD Sharing: NO. Countries: 1. Publications: 0.
Behavioral Consultation for HIV+ Older Adults Prescribed Opioids for Chronic Pain
ClinicalTrials.gov study NCT02272829. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing
ClinicalTrials.gov study NCT03825549. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Changes in Prescribing Behavior of ER/LA Opioid Prescribers
ClinicalTrials.gov study NCT02920762. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.