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97 results for “protein homeostasis”
Lipidomic datasets for: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
<p>Transmembrane protein 135 (TMEM135) is thought to participate in the cellular response to increased intracellular lipids yet no defined molecular function for TMEM135 in lipid metabolism has been identified. In this study, we performed a lipid analysis of tissues from <em>Tmem135</em> mutant mice and found striking reductions of docosahexaenoic acid (DHA) across all <em>Tmem135</em> mutant tissues, indicating a role of TMEM135 in the production of DHA. Since all enzymes required for DHA synthesis remain intact in <em>Tmem135</em> mutant mice, we hypothesized that TMEM135 is involved in the export of DHA from peroxisomes. The <em>Tmem135</em> mutation likely leads to the retention of DHA in peroxisomes, causing DHA to be degraded within peroxisomes by their beta-oxidation machinery. This may lead to generation or alteration of ligands required for the activation of peroxisome proliferator-activated receptor a (PPARa) signaling, which in turn could result in increased peroxisomal number and beta-oxidation enzymes observed in <em>Tmem135</em> mutant mice. We confirmed this effect of PPARa signaling by detecting decreased peroxisomes and their proteins upon genetic ablation of <em>Ppara</em> in <em>Tmem135</em> mutant mice. Using <em>Tmem135</em> mutant mice, we also validated the protective effect of increased peroxisomes and peroxisomal beta-oxidation on the metabolic disease phenotypes of leptin mutant mice which has been observed in previous studies. Thus, we conclude that TMEM135 has a role in lipid homeostasis through its function in peroxisomes.</p>
Data from: Protein kinase FaSnRK2.6 phosphorylates transcription factor FabHLH3 to regulate anthocyanin homeostasis during strawberry fruit ripening
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Lipidomic datasets for: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
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Hoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis
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Effects of a Small Protein and Lipid Preload on Glucose Tolerance in Subjects With Impaired Glucose Homeostasis
ClinicalTrials.gov study NCT02342834. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Nutritional Supplementation on Protein and Energy Homeostasis in Malnourished Chronic Hemodialysis Patients
ClinicalTrials.gov study NCT00244075. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data from: Metal tolerance protein MTP6 affects mitochondrial iron and manganese homeostasis in cucumber
<p><span><b>NOTICE</b></span>: The Editor-in-Chief and Publisher of <i>Journal of Experimental Botany</i> have taken the decision to retract the article related to this dataset due to concern over image manipulation and duplication. Please note, Dryad cannot verify whether the underlying data published is reliable for reuse. Visit this link to view the retraction notice and concerns raised: <a href="https://doi.org/10.1093/jxb/ery342" rel="noopener noreferrer">https://doi.org/10.1093/jxb/ery342</a></p> <p>Members of the cation diffusion facilitator family have been identified in all kingdoms of life. They have been divided into three subgroups – Zn-CDF, Fe/Zn-CDF and Mn-CDF – based on their putative specificity to transported metal ions. The plant metal tolerance 6 (MTP6) proteins fall into the Fe/Zn-CDF subgroup, however their function in iron/zinc transport has not been confirmed yet. Here we characterize the MTP6 protein from cucumber. When expressed in yeast and protoplasts isolated from A. thaliana cells, CsMTP6 localized in mitochondria and contributed to the efflux of iron and manganese from the mitochondria. The immunolocalization of CsMTP6 in cucumber membranes confirmed that CsMTP6 is associated with mitochondria. The root expression and protein level of CsMTP6 were significantly up-regulated in conditions of iron deficiency and iron excess but were not affected by Mn availability. These results indicate that plant MTP6 proteins contribute to the distribution of iron and manganese between the cytosol and mitochondria of plant cells and are regulated by Fe to maintain the mitochondrial and cytosolic iron homeostasis under various Fe availability.</p>
Data from: Metal tolerance protein MTP6 affects mitochondrial iron and manganese homeostasis in cucumber
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Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis
GEO Series GSE235750. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Prionic protein gene dosage is critical for maintenance of neuronal homeostasis of hippocampal circuits
GEO Series GSE16223. Mus musculus. 12 samples. Type: Expression profiling by array.
Dysfunctions in nonsense-mediated decay, protein homeostasis, OXPHOS function, and brain connectivity in ALS-FUS mice with cognitive deficits
GEO Series GSE157713. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1
GEO Series GSE268418. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
The G-Protein-Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis
GEO Series GSE261821. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis
GEO Series GSE183042. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Zinc finger protein overexpression improves glucose homeostasis in mice
GEO Series GSE83541. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response
GEO Series GSE26801. Saccharomyces cerevisiae. 14 samples. Type: Expression profiling by array.
The submandibular and sublingual glands maintain oral microbial homeostasis through multiple antimicrobial proteins
GEO Series GSE216476. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Chd8 haploinsufficiency impairs early brain development and impacts protein homeostasis later in life
GEO Series GSE142208. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Expression of a dominant‐negative AtNEET‐H89C protein disrupts iron–sulfur metabolism and iron homeostasis in Arabidopsis
GEO Series GSE127300. Arabidopsis thaliana. 21 samples. Type: Expression profiling by high throughput sequencing.
Cytosolic aggregation of mitochondrial proteins enhances degeneration of cellular homeostasis
GEO Series GSE147284. Saccharomyces cerevisiae. 68 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.