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115 results for “regulatory evolution”
Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes
<p><br> Supplementary datasets accompanying paper: </p> <p>stage_peaks_anc_sel.xlsx : ATAC peaks with classification, conservation and binding sites<br> Pliv.mfuzz.enrichGO.txt : GO enrichment in MFuzz cluster<br> Pliv_genes_master_filt.xlsx : Gene models with corresponding information<br> bindetect_results_anf.txt : results of TOBIAS<br> hits_pprx_cl0_ord3vrr+Et_red.fa : alignment of homeobox sequences<br> Pliv_aH2p.gn.gtf.gz : annotation in GTF format<br> Pliv_PqN3S_sm.fa.gz : genome of P. livius <br> ansr_*_network.tsv.gz : Stage specific networks from ANANSE analysis<br> ATAC_pks_normcov.tsv : Coverage of unified peaks for ATAC-seq<br> Cttg_pks_normcov.tsv : Coverage of unified peaks for Cut-and-tag H3K27Ac data<br> lncRNA_stgSpe_fpkm.tsv : Expression levels (FPKM) for predicted lncRNAs for available RNA-seq samples <br> Split_Urchin_FPKMs.clean.txt.gz : Expression levels for unified ATAc-seq peaks following direct and reverse orientation</p> <p> </p> <p> </p> <p> </p> <p> </p>
Mammalian Evolution of Human cis-regulatory Elements and Transcription Factor Binding Sites
<p>Code and data associated with the manuscript entitled "Mammalian Evolution of Human cis-regulatory Elements and Transcription Factor Binding Sites "</p>
Genome evolution is associated with nutrition-responsive regulatory development in horned dung beetles
<p>The Scarabaeinae, or true dung beetles, are a hyper-diverse clade of insects of ecological, evolutionary, and agricultural significance and have long served as informative models of evolutionary ecology and development. Perhaps the most conspicuous of their unique traits are head horns, novel structures that serve as secondary sexual weapons, exhibit extraordinary developmental plasticity, and have fueled one of the most dramatic morphological radiations in the animal kingdom. In this study, we investigate the evolutionary basis for dung beetle traits - including horns - via comparative genomic and developmental assays. We present chromosome-level genome assemblies of three dung beetle species in the species-rich Onthophagini tribe (> 2500 extant species) including <em>Onthophagus taurus</em>, <em>Onthophagus sagittarius</em>, and <em>Digitonthophagus gazella</em>. Contrasting these assemblies with seven other species across the order Coleoptera identifies rapidly evolving gene families associated with metabolic regulation of developmental plasticity and metamorphosis. Intraspecific comparisons of chromatin accessibility in developing head horns of <em>O. taurus</em> identify distinct cis-regulatory architectures underlying sex- and nutrition-responsive development of this novel trait, including a large proportion of recently evolved regulatory elements sensitive to horn morph determination. Binding motifs of diverse developmental transcription factors are enriched in these nutrition-responsive open chromatin regions, including the early embryonic patterning gene <em>twist</em>. Using RNA interference (RNAi), we show <em>twist</em> has been co-opted into the beetle horn regulatory network to mediate differential horn morphogenesis in alternate male morphs via its interactions with nutrition-sensitive DNA-binding sites, highlighting the utility of this approach in identifying new developmental regulators of morphological evolution. These results demonstrate gene networks are highly evolvable transducers of environmental and genetic signals critical for the formation and diversification of developmental traits, established in part by condition-responsive chromatin accessibility. Further, this work provides new reference-quality genome assemblies of three dung beetles that will bolster future developmental, ecological, and evolutionary studies of this insect group.</p>
The telomere regulatory gene POT1 responds to stress and predicts performance in nature: implications for telomeres and life history evolution
<p>Telomeres are emerging as correlates of fitness-related traits and may be important mediators of ecologically relevant variation in life history strategies. Growing evidence suggests that telomere dynamics can be more predictive of performance than length itself, but very little work considers how telomere regulatory mechanisms respond to environmental challenges or influence performance in nature. Here, we combine observational and experimental datasets from free-living tree swallows (<i>Tachycineta bicolor</i>) to assess how performance is predicted by the telomere regulatory gene POT1, which encodes a shelterin protein that sterically blocks telomerase from repairing the telomere. First, we show that lower POT1 gene expression was associated with higher female quality, <i>i.e.</i> earlier breeding and heavier body mass. We next challenged mothers with an immune stressor (lipopolysaccharide injection) that led to 'sickness' in mothers and 24h of food restriction in their offspring. While POT1 did not respond to maternal injection, females with lower constitutive POT1 gene expression were better able to maintain feeding rates following treatment. Maternal injection also generated a one-day stressor for chicks, which responded with lower POT1 gene expression and elongated telomeres. Other putatively stress-responsive mechanisms (i.e. glucocorticoids, antioxidants) showed marginal responses in stress-exposed chicks. Model comparisons indicated that POT1 mRNA abundance was a largely better predictor of performance than telomere dynamics, indicating that telomere regulators may be powerful modulators of variation in life history strategies.</p>
Genome evolution is associated with nutrition-responsive regulatory development in horned dung beetles
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The telomere regulatory gene POT1 responds to stress and predicts performance in nature: implications for telomeres and life history evolution
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Data from: The evolution of heat shock protein sequences, cis-regulatory elements, and expression profiles in the eusocial Hymenoptera
Background: The eusocial Hymenoptera have radiated across a wide range of thermal environments, exposing them to significant physiological stressors. We reconstructed the evolutionary history of three families of Heat Shock Proteins (Hsp90, Hsp70, Hsp40), the primary molecular chaperones protecting against thermal damage, across 12 Hymenopteran species and four other insect orders. We also predicted and tested for thermal inducibility of eight Hsps from the presence of cis-regulatory heat shock elements (HSEs). We tested whether Hsp induction patterns in ants were associated with different thermal environments. Results: We found evidence for duplications, losses, and cis-regulatory changes in two of the three gene families. One member of the Hsp90 gene family, hsp83, duplicated basally in the Hymenoptera, with shifts in HSE motifs in the novel copy. Both copies were retained in bees, but ants retained only the novel HSE copy. For Hsp70, Hymenoptera lack the primary heat-inducible orthologue from Drosophila melanogaster and instead induce the cognate form, hsc70-4, which also underwent an early duplication. Episodic diversifying selection was detected along the branch predating the duplication of hsc70-4 and continued along one of the paralogue branches after duplication. Four out of eight Hsp genes were heat-inducible and matched the predictions based on presence of conserved HSEs. For the inducible homologues, the more thermally tolerant species, Pogonomyrmex barbatus, had greater Hsp basal expression and induction in response to heat stress than did the less thermally tolerant species, Aphaenogaster picea. Furthermore, there was no trade-off between basal expression and induction. Conclusions: Our results highlight the unique evolutionary history of Hsps in eusocial Hymenoptera, which has been shaped by gains, losses, and changes in cis-regulation. Ants, and most likely other Hymenoptera, utilize lineage-specific heat inducible Hsps, whose expression patterns are associated with adaptive variation in thermal tolerance between two ant species. Collectively, our analyses suggest that Hsp sequence and expression patterns may reflect the forces of selection acting on thermal tolerance in ants and other social Hymenoptera.
Emergence of Supercoiling-Mediated Regulatory Networks through the Evolution of Bacterial Chromosome Organization
<p>Data generated using <a href="https://gitlab.inria.fr/tgrohens/evotsc">EvoTSC</a> and used in the <a href="https://doi.org/10.24072/pci.mcb.100198">Emergence of Supercoiling-Mediated Regulatory Networks through the Evolution of Bacterial Chromosome Organization</a> paper.</p> <p>This data is also used in Chapter 5 of my <a href="https://gitlab.inria.fr/tgrohens/phd">PhD thesis</a>.</p>
Evidence for compensatory evolution within pleiotropic regulatory elements
<p>In this archive we provide data and code to reproduce the results of our paper:<br>"Evidence for compensatory evolution within pleiotropic regulatory elements" by Kliesmete et al.</p>
Data from: Convergent regulatory evolution and loss of flight in palaeognathous birds
A core question in evolutionary biology is whether convergent phenotypic evolution is driven by convergent molecular changes in proteins or regulatory regions. We combined phylogenomic, developmental, and epigenomic analysis of 11 new genomes of paleognathous birds, including an extinct moa, to show that convergent evolution of regulatory regions, more so than protein-coding genes, is prevalent among developmental pathways associated with independent losses of flight. A Bayesian analysis of 284,001 conserved noncoding elements, 60,665 of which are corroborated as enhancers by open chromatin states during development, identified 2355 independent accelerations along lineages of flightless paleognaths, with functional consequences for driving gene expression in the developing forelimb. Our results suggest that the genomic landscape associated with morphological convergence in ratites has a substantial shared regulatory component.
Dataset to article "Distinct traits of structural and regulatory evolutional conser-vation of human genes with specific focus on major cancer mo-lecular pathways"
<p>Abstract: Evolution of protein coding genes has both structural and regulatory components. The first can be assessed by measuring the ratio of non-synonymous to synonymous nucleotide sub-stitutions. The second component can be measured as the normalized proportion of transposable elements that used as the regulatory elements. For the first time, we characterized in parallel the regulatory and structural evolutionary profiles for 10,890 human genes and 2,972 molecular pathways. We observed ~0.1 correlation between the structural and regulatory metrics at the gene level, which appeared much higher (~0.4) at the pathway level. We deposited the data in the publicly available database RetroSpect accessible at https://retrospect.oncobox.com. We also analyzed evolutionary dynamics of six cancer pathways of two major axes: Notch/WNT/Hedgehog and AKT/mTOR/EGFR. The Hedgehog pathway had both components slower, whereas the Akt pathway had clearly accelerated structural evolution. In particular, the major hub nodes Akt and beta-catenin showed both components strongly decreased, whereas two major regulators of Akt TCL1 and CTMP had outstandingly high evolutionary rates. We al-so noticed structural conservation of serine/threonine kinases and the genes related to guanosine metabolism in cancer signaling: GPCRs, G proteins, and small regulatory GTPases (Src, Rac, Ras); however, this was compensated by the accelerated regulatory evolution.</p>
Data from: The 5S rDNA gene family in mollusks: characterization of transcriptional regulatory regions, prediction of secondary structures, and long-term evolution, with special attention to Mytilidae mussels
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Data from: The evolution of heat shock protein sequences, cis-regulatory elements, and expression profiles in the eusocial Hymenoptera
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Data from: Genetic drift dominates genome-wide regulatory evolution following an ancient whole genome duplication in Atlantic salmon
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Data from: Convergent regulatory evolution and loss of flight in palaeognathous birds
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Data from: Molecular evolution of the neural crest regulatory network in ray-finned fish
Gene regulatory networks (GRN) are central to developmental processes. They are composed of transcription factors and signaling molecules orchestrating gene expression modules that tightly regulate the development of organisms. The neural crest (NC) is a multipotent cell population that is considered a key innovation of vertebrates. Its derivatives contribute to shaping the astounding morphological diversity of jaws, teeth, head skeleton or pigmentation. Here, we study the molecular evolution of the NC GRN by analyzing patterns of molecular divergence for a total of 36 genes in 16 species of bony fishes. Analyses of non-synonymous to synonymous substitution rate ratios (dN/dS) support patterns of variable selective pressures among genes deployed at different stages of NC development, consistent with the developmental hourglass model. Model-based clustering techniques of sequence features support the notion of extreme conservation of NC-genes across the entire network. Our data show that most genes are under strong purifying selection that is maintained throughout ray-finned fish evolution. Late NC development genes reveal a pattern of increased constraints in more recent lineages. Additionally, seven of the NC-genes showed signs of relaxation of purifying selection in the famously species-rich lineage of cichlid fishes. This suggests that NC genes might have played a role in the adaptive radiation of cichlids by granting flexibility in the development of NC-derived traits – suggesting an important role for NC network architecture during the diversification in vertebrates.
Data from: Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations
The use of whole-genome phylogenetic analysis has revolutionized our understanding of the evolution and spread of many important bacterial pathogens due to the high resolution view it provides. However, the majority of such analyses do not consider the potential role of accessory genes when inferring evolutionary trajectories. Moreover, the recently discovered importance of the switching of gene regulatory elements suggests that an exhaustive analysis, combining information from core and accessory genes with regulatory elements could provide unparalleled detail of the evolution of a bacterial population. Here we demonstrate this principle by applying it to a worldwide multi-host sample of the important pathogenic E. coli lineage ST131. Our approach reveals the existence of multiple circulating subtypes of the major drug–resistant clade of ST131 and provides the first ever population level evidence of core genome substitutions in gene regulatory regions associated with the acquisition and maintenance of different accessory genome elements.
Data from: The role of cis regulatory evolution in maize domestication
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Data from: Molecular evolution of the neural crest regulatory network in ray-finned fish
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Data from: Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.