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19 results for “renal progenitor cells”
Data from: Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis
Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and is critical for normal nephron number, while low nephron number is implicated in hypertension and renal disease. Ureteric bud growth and branching requires GDNF signaling from the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase and coreceptor Gfrα1; Ret signaling up-regulates transcription factors Etv4 and Etv5, which are also critical for branching. Despite extensive knowledge of the genetic control of these events, it is not understood, at the cellular level, how renal branching morphogenesis is achieved or how Ret signaling influences epithelial cell behaviors to promote this process. Analysis of chimeric embryos previously suggested a role for Ret signaling in promoting cell rearrangements in the nephric duct, but this method was unsuited to study individual cell behaviors during ureteric bud branching. Here, we use Mosaic Analysis with Double Markers (MADM), combined with organ culture and time-lapse imaging, to trace the movements and divisions of individual ureteric bud tip cells. We first examine wild-type clones and then Ret or Etv4 mutant/wild-type clones in which the mutant and wild-type sister cells are differentially and heritably marked by green and red fluorescent proteins. We find that, in normal kidneys, most individual tip cells behave as self-renewing progenitors, some of whose progeny remain at the tips while others populate the growing UB trunks. In Ret or Etv4 MADM clones, the wild-type cells generated at a UB tip are much more likely to remain at, or move to, the new tips during branching and elongation, while their Ret−/− or Etv4−/− sister cells tend to lag behind and contribute only to the trunks. By tracking successive mitoses in a cell lineage, we find that Ret signaling has little effect on proliferation, in contrast to its effects on cell movement. Our results show that Ret/Etv4 signaling promotes directed cell movements in the ureteric bud tips, and suggest a model in which these cell movements mediate branching morphogenesis.
Data from: Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis
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Isolation and characterization of progenitor-like cells from human renal proximal tubules
GEO Series GSE23911. Homo sapiens. 6 samples. Type: Expression profiling by array.
WT1+ parietal epithelial progenitor cells are essential for renal proximal tubule repair and regeneration
GEO Series GSE184601. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
The gene expression profile of renal cell carcinoma cell line (786-O) versus prostate cancer cell line (PC3) in co-culture with primary murine muscle progenitor cells
GEO Series GSE61942. Homo sapiens. 12 samples. Type: Expression profiling by array.
The Role of Renal Progenitors and Polyploid Tubular Cell Response in Glomerular and Tubular Diseases
ClinicalTrials.gov study NCT06325059. IPD Sharing: NO. Countries: 1. Publications: 0.
Analyze the transcriptional signature of primary human renal progenitor cells (hRPCs)
GEO Series GSE291924. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Epigenome and transcriptome profiling of urine progenitor renal cells
GEO Series GSE235813. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing.
miR-1915 and miR-1225-5p Regulate The Expression of CD133, PAX-2 and TLR2 in Adult Renal Progenitor Cells
GEO Series GSE42391. Homo sapiens. 16 samples. Type: Non-coding RNA profiling by array.
JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis.
GEO Series GSE211892. Homo sapiens. 6 samples. Type: Expression profiling by array.
Renal progenitor cell gene expression profiling
GEO Series GSE8611. Homo sapiens. 12 samples. Type: Expression profiling by array.
A Comprehensive Molecular Portrait of Human Urine-derived Renal Progenitor Cells
GEO Series GSE128281. Homo sapiens. 20 samples. Type: Expression profiling by array.
Arsenite Exposure to Human Renal Progenitor Cells (HRTPT) Produces a Reversible Epithelial Mesenchymal Transition (EMT)
GEO Series GSE215904. Homo sapiens. 18 samples. Type: Expression profiling by array.
Yamanaka factors-induced rejuvenation and immortalization of SIX2-positive renal progenitor cells from urine obtained from a male of African origin
GEO Series GSE299018. Homo sapiens. 3 samples. Type: Expression profiling by array.
Analyze the transcriptional signature of human primary culture of CD133+ CD24+ renal progenitor cells
GEO Series GSE273762. Homo sapiens. 6 samples. Type: Expression profiling by array.
Lhx1 is required for specification of renal progenitor cell field
GEO Series GSE24392. Xenopus laevis. 12 samples. Type: Expression profiling by array.
Inhibition of prolyl hydroxylase promotes the reprogramming of Sox9+ renal progenitor cells and renal regeneration
GEO Series GSE247560. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Urine progenitor renal cells
GEO Series GSE235814. Homo sapiens. 88 samples. Type: Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing.
Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model
GEO Series GSE107657. Mus musculus. 6 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.