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361
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ShareScore release 0.9.0
Dataset results
361 results for “respiratory disease”
Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease
<p><span><span><span><span><span><span><span><span><span><span><span>Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airway and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with elevated concentration of proteins associated with apoptosis, tissue repair and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. 1 year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to ongoing activation of cytotoxic T cells. </span></span></span></span></span></span></span></span></span></span></span></p>
Innovation in chronic respiratory diseases: biodiversity and commons – WHO GARD workshop [video]
<p>00:00 Introduction by Letitia Harding.</p> <p>00:15 Embedding biodiversity in digitally-enabled, patient-centered care pathways for airway diseases – Dr Jean Bousquet.</p> <p>09:35 Open-source respiratory health commons. 15 projects communities can adapt, repair, reproduce for low cost medical care (libre and open-source tech) [<a href="https://doi.org/10.5281/zenodo.5515632">download presentation</a>].</p> <p>18:13 Open discussion – Facilitation by Letitia Harding.</p> <p>28:56 End.</p>
Diagnosis of Aspirin Hypersensitivity in Aspirin Exacerbated Respiratory Disease
ClinicalTrials.gov study NCT01320072. IPD Sharing: NO. Countries: 1. Publications: 1.
Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease
Open the record for dataset details and reuse information.
Fatal enhanced respiratory syncytial virus disease in toddlers
<p>In 1967, two toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (FIRSV) in the United States died from enhanced RSV disease (ERD), a severe form of illness resulting from aberrant priming of the antiviral immune response during vaccination. Up to 80% of immunized children subsequently exposed to wild-type virus were hospitalized. These events hampered RSV vaccine development for decades. In this manuscript, we provide a characterization of the clinical, immunopathological, and transcriptional signature of fatal human ERD, outlining novel evidence for safety evaluation of RSV vaccines and a framework for understanding disease enhancement for pathogens in general. These are the scanned histology slides from this study. </p>
Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease.
<p>Contains all intermediate data files for the article <strong>Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease, </strong>Quinn-Bohmann et al. 2024. </p> <p>NP and OP refers to nasopharyngeal or oropharyngeal samples, respectively. As some study identifiers are duplicated across these groups, qiime_NP and qiime_OP should be unzipped in distinct directories. The same applies for metadata data files. </p> <p>Analyses of these data can be found at https://github.com/Gibbons-Lab/2023_URTmetaanalysis/tree/main. </p>
Figure 1 in Detection of respiratory viruses and expression of inflammatory cytokines in patients with acute exacerbation chronic obstructive pulmonary disease in Mongolia China
Figure 1. Distribution of Viruses.
SARS-CoV-2 viral loads across the upper and lower respiratory tract, sex, disease severity and age groups for adult and pediatric COVID-19
<p>This dataset shows SARS-CoV-2 respiratory viral loads (viral RNA concentration in the respiratory tract) in the upper and lower respiratory tract for age, sex and COVID-19 severity groups. The data were obtained from a systematic review. The model outputs show the Weibull distributions, case percentiles, and sensitivity & specificity when using SARS-CoV-2 viral load (URT or LRT) as a prognostic indicator. See our paper for more information.</p>
Efficacy of Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children
ClinicalTrials.gov study NCT06148194. IPD Sharing: YES. Countries: 1. Publications: 9.
LYT-100 in Post-acute COVID-19 Respiratory Disease
ClinicalTrials.gov study NCT04652518. IPD Sharing: Not stated. Countries: 8. Publications: 1.
MEDI-524 (Motavizumab) for the Prevention of Respiratory Sycytial Virus (RSV) Disease Among Native American Indian Infants in the Southwestern United States
ClinicalTrials.gov study NCT00121108. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of MEDI-524 (Motavizumab) for the Prophylaxis of Serious Respiratory Syncytial Virus (RSV) Disease in High-Risk Children
ClinicalTrials.gov study NCT00129766. IPD Sharing: Not stated. Countries: 24. Publications: 1.
Clesrovimab (MK-1654) in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease (MK-1654-007)
ClinicalTrials.gov study NCT04938830. IPD Sharing: YES. Countries: 27. Publications: 2.
A Prospective, Epidemiological Study to Assess the Disease Burden of Respiratory Syncytial Virus Associated, Suspected Lower Respiratory Tract Infections in Newborns, From 0 to 2 Years of Age and Risk
ClinicalTrials.gov study NCT01995175. IPD Sharing: NO. Countries: 8. Publications: 3.
Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease
ClinicalTrials.gov study NCT01778465. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
ClinicalTrials.gov study NCT02183519. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Use of Aptar Digital Health's Respiratory Disease Management Platform for Asthma
ClinicalTrials.gov study NCT06364527. IPD Sharing: YES. Countries: 1. Publications: 15.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)
ClinicalTrials.gov study NCT04551898. IPD Sharing: YES. Countries: 4. Publications: 2.
A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared
ClinicalTrials.gov study NCT06389487. IPD Sharing: YES. Countries: 6. Publications: 0.
Effectiveness of Respiratory Physiotherapy in Children With Neuromuscular Disease
ClinicalTrials.gov study NCT02743702. IPD Sharing: Not stated. Countries: 1. Publications: 6.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.