Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,228
datasets available to search
ShareScore release 0.9.0
Dataset results
1,228 results for “sedative”
Corticothalamic communication under analgesia, sedation and gradual ischemia: a multimodal model of controlled gradual cerebral ischemia in pig
Open the record for dataset details and reuse information.
NON-ANESTHESIOLOGIST ADMINISTERED PROPOFOL SEDATION IN SCREENING COLONOSCOPY
<p> </p> <p>These data came from a. prospective cohort study about cardiorespiratory complications in colorectal cancer screening colonoscopy, comparing two sedation schemes: traditional sedation with fentanyl and midazolam, versus combined Propofol sedation administered by non-anesthesiologists. These screening colonoscopies were performed between 2018 and 2019. We used the ASA and Ramsay scales to evaluate comorbidities and sedation levels. Cardiopulmonary adverse events were defined as: systolic blood pressure<90 mmHg, oxygen saturation <90% or disrrythmia lasting for more than 60 seconds..We recorded the management and outcomes of all these unplanned events. Other data as age, gender and body mass index were recorded as well., We have stored our data as a csv fyle. </p> <p> </p>
Randomized Trial of Sedative Choice for Intubation
ClinicalTrials.gov study NCT05277896. IPD Sharing: YES. Countries: 1. Publications: 3.
Virtual Reality as a Substitute for Procedural Sedation During Epidural Steroid Injections
ClinicalTrials.gov study NCT04887285. IPD Sharing: YES. Countries: 1. Publications: 2.
Figure S1 Surgical extraction of supernumerary teeth under sedation and analgesia, and a periapical radiograph 2 weeks later.
<p>Figure S1 Surgical extraction of supernumerary teeth under sedation and analgesia, and a periapical radiograph 2 weeks later.</p>
Zebrafish behavioral profiling identifies ligands, targets, and neurons related to sedation and paradoxical excitation
<p>Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity — a phenomenon known as paradoxical excitation. Previous studies have identified GABAA receptors as the primary targets of most anesthetic drugs, but how these compounds produce paradoxical excitation is poorly understood. To identify and understand such compounds, we applied a behavior-based drug profiling approach. Here, we show that a subset of central nervous system depressants cause paradoxical excitation in zebrafish. Using this behavior as a readout, we screened thousands of compounds and identified dozens of hits that caused paradoxical excitation. Many hit compounds modulated human GABAA receptors, while others appeared to modulate different neuronal targets, including the human serotonin-6 receptor. Ligands at these receptors generally decreased neuronal activity, but paradoxically increased activity in the caudal hindbrain. Together, these studies identify ligands, targets, and neurons affecting sedation and paradoxical excitation in vivo in zebrafish.</p>
Xenon's sedative effect is at least partly mediated by interaction with the cyclic nucleotide-binding domain (CNBD) of HCN2 channels expressed by thalamocortical neurons of the ventrobasal nucleus in mice
<p>Xenon (70%xenon, 30%O2) application in the last 10 min of the open field test manage to sedate wild-type mice but not HCN2EA. Wild-type mice in the xenon_wild-type video can be seen moving freely in the early minutes but the general activity starts to decrease sharply in the last 2 minutes and is absent between min 9 and 10 while HCN2EA mice in the xenon_HCN2EA can be seen moving throughout the entire time of the xenon gas mixture application.</p>
Etomidate vs. Midazolam for Sedation During ERCP
ClinicalTrials.gov study NCT02027311. IPD Sharing: Not stated. Countries: 1. Publications: 26.
SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke
ClinicalTrials.gov study NCT03263117. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP
ClinicalTrials.gov study NCT07333859. IPD Sharing: NO. Countries: 0. Publications: 3.
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
ClinicalTrials.gov study NCT06203405. IPD Sharing: YES. Countries: 1. Publications: 37.
Effect of Music on the Sedative Use During Coronary Angioplasty
ClinicalTrials.gov study NCT03817775. IPD Sharing: NO. Countries: 1. Publications: 4.
Sedation and Pain (The Effect of IV Sedation on Pain Perception)
ClinicalTrials.gov study NCT00853333. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Precision Sedation in Intensive Care
ClinicalTrials.gov study NCT06991777. IPD Sharing: NO. Countries: 1. Publications: 20.
Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
ClinicalTrials.gov study NCT03139279. IPD Sharing: NO. Countries: 1. Publications: 12.
Oral Sedation During Cervical Dilator Placement
ClinicalTrials.gov study NCT03202550. IPD Sharing: YES. Countries: 1. Publications: 3.
The Effects of Sedatives on Tobacco Use Disorder
ClinicalTrials.gov study NCT03813121. IPD Sharing: NO. Countries: 1. Publications: 0.
Alternative Sedation During Bronchoscopy
ClinicalTrials.gov study NCT01158820. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
ClinicalTrials.gov study NCT02404610. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol
ClinicalTrials.gov study NCT01489891. IPD Sharing: Not stated. Countries: 1. Publications: 7.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.