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13 results for “self-association”

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zenodo40/100

Measurement of solubility product reveals the interplay of oligomerization and self-association for defining condensate formation

This data set includes the raw confocal microscopy images, DLS, and SEC-MALS data used for Chattaraj, Baltaci, et al. Mol. Biol. Cell. 2024.

opencc-by-4.0Sep 2024View details →

zenodo36/100

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein duo ESAT-6 and CFP-10. CFP-10 likely acts as a chaperone, while ESAT-6 likely disrupts phagosomal membrane stability via a largely unknown mechanism. we employ a series of biochemical analyses, protein modeling techniques, and a novel ESAT-6-specific nanobody to gain insight into the ESAT-6’s mode of action. First, we measure the binding kinetics of the tight 1:1 complex formed by ESAT-6 and CFP-10 at neutral pH. Subsequently, we demonstrate a rapid self-association of ESAT-6 into large complexes under acidic conditions, leading to the identification of a stable tetrameric ESAT-6 species. Using molecular dynamics simulations, we pinpoint the most probable interaction interface. Furthermore, we show that cytoplasmic expression of an anti-ESAT-6 nanobody blocks Mtb replication, thereby underlining the pivotal role of ESAT-6 in intracellular survival. Together, these data suggest that ESAT-6 acts by a pH dependent mechanism to establish two-way communication between the cytoplasm and the Mtb-containing phagosome.

opencc-by-4.0Nov 2023View details →

zenodo36/100

Comparative Study of Molecular Mechanics Force Fields for β-peptidic Foldamers: Folding and Self-Association

Molecular dynamics simulation input files and Python scripts used for preparing the runs and analyzing the trajectories.

opencc-by-4.0Feb 2023View details →

dryad36/100

Data from: Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice

Advances in tau biology and the difficulties of amyloid-directed immunotherapeutics have heightened interest in tau as a target for small molecule drug discovery for neurodegenerative diseases. Here, we evaluated OLX-07010, a small molecule inhibitor of tau self-association, for the prevention of tau aggregation. The primary endpoint of the study was statistically significant reduction of insoluble tau aggregates in treated JNPL3 mice compared with Vehicle-control mice. Secondary endpoints were dose-dependent reduction of insoluble tau aggregates, reduction of phosphorylated tau, and reduction of soluble tau. This study was performed in JNPL3 mice, which are representative of inherited forms of 4-repeat tauopathies with the P301L tau mutation (eg, progressive supranuclear palsy and frontotemporal dementia). The P301L mutation makes tau prone to aggregation; therefore, JNPL3 mice present a more challenging target than mouse models of human tau without mutations. JNPL3 mice were treated from 3 to 7 months of age with Vehicle, 30 mg/kg compound dose, or 40 mg/kg compound dose. Biochemical methods were used to evaluate self-associated tau, insoluble tau aggregates, total tau, and phosphorylated tau in the hindbrain, cortex, and hippocampus. The Vehicle group had higher levels of insoluble tau in the hindbrain than the Baseline group; treatment with 40 mg/kg compound dose prevented this increase. In the cortex, the levels of insoluble tau were similar in the Baseline and Vehicle groups, indicating that the pathological phenotype of these mice was beginning to emerge at the study endpoint and that there was a delay in the development of the phenotype of the model as originally characterized. No drug-related adverse effects were observed during the 4-month treatment period.

opencc-zeroJun 2023View details →

dryad36/100

Data from: Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice

Open the record for dataset details and reuse information.

publicJun 2023View details →

zenodo32/100

Lipid-driven SRC self-association modulates its transformation capacity

Data Type: SPR data, sensorgrams with reference flow cell correction. Data format: Comma-delimited text file  Data Type: AFM raw data  Data format: Binary files jpk format

opencc-by-4.0May 2022View details →

zenodo32/100

Disordered region of human eIF4B orchestrates a dynamic balance across self-association landscape

Trajectory files to visualize the simulations of coarse-grained eIF4B.

opencc-by-4.0Jun 2024View details →

dryad28/100

Ventromedial prefrontal cortex drives the prioritization of self-associated stimuli in working memory

Humans show a pervasive bias for processing self- over other-related information, including in working memory (WM), where people prioritize the maintenance of self- (over other-) associated cues. To elucidate the neural mechanisms underlying this self-bias, we paired a self- vs. other-associated spatial WM task with functional magnetic resonance imaging (fMRI) and transcranial direct current stimulation (tDCS). Maintaining self- (over other-) associated cues resulted in enhanced delay-period activity in classic WM regions (frontoparietal cortex), and in superior multivoxel pattern decoding of the cue locations from visual cortex. Moreover, ventromedial prefrontal cortex (VMPFC) displayed enhanced functional connectivity with WM regions during maintenance of self-associated cues, which predicted individuals' behavioral self-prioritization effects. In a follow-up tDCS experiment, we targeted VMPFC with either excitatory (anodal), inhibitory (cathodal), or sham tDCS. Cathodal tDCS eliminated the self-prioritization effect. These findings provide strong converging evidence for a causal role of VMPFC in driving self-prioritization effects in WM.

opencc-zeroMay 2020View details →

dryad28/100

Ventromedial prefrontal cortex drives the prioritization of self-associated stimuli in working memory

Open the record for dataset details and reuse information.

publicMay 2020View details →

geo24/100

Bombyx Vasa sequesters transposon mRNAs in nuage via phase separation requiring RNA binding and self-association [RNA-Seq]

GEO Series GSE213915. Bombyx mori. 4 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenMar 2023View details →

geo24/100

Self-associated molecular patterns mediate cancer immune evasion by engagement of Siglec receptors

GEO Series GSE115305. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenDec 2018View details →

geo24/100

Bombyx Vasa sequesters transposon mRNAs in nuage via phase separation requiring RNA binding and self-association [RIP-Seq]

GEO Series GSE213914. Bombyx mori. 4 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenMar 2023View details →

geo20/100

Bombyx Vasa sequesters transposon mRNAs in nuage via phase separation requiring RNA binding and self-association

GEO Series GSE213917. Bombyx mori. 8 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenMar 2023View details →

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Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas

neuroscienceopenDocumentation, web resources, and API references are available online.

Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage

behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.

Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb

electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.

Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl

behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.

Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro

neuroscienceopenPublished datasets are available on demand over the internet.

Last verified 2026-04-29Open record