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35 results for “sensitisation”
Dataset for manuscript Tracing Quartz Provenance: A Multi-Disciplinary Investigation of Luminescence Sensitisation Mechanisms of Quartz from Granite Source Rocks and Derived Sediments
<p><span>Quartz optically stimulated luminescence (OSL) sensitivity as well as some electron spin resonance (ESR) and cathodoluminescence (CL) signals have been empirically proposed as provenance indicators. Sensitivity is defined as luminescence emitted in response to a given dose per unit mass. While it is largely believed to be acquired by earth surface processes, recent studies bring evidence that sensitisation processes depend on source geology.</span></p> <p><span>Here we combine OSL and thermoluminescence (TL), ESR and CL analyses to understand the mechanisms of quartz OSL sensitisation. We investigate granites and their derived sediments from catchments draining simple lithologies of known age that display contrasting OSL sensitisation behaviour both in nature and during irradiation and light exposure laboratory experiments. The sample displaying increased OSL sensitisation is characterised by TL emission at intermediate temperatures (150-250 °C), Ti-related signals in CL, and Ti and Ge lithium compensated signals in ESR. <span>The insensitive samples either lack or exhibit very weak such characteristics and contain several times less amount of trace titanium measured by </span></span><span>laser ablation inductively coupled plasma mass spectrometry (</span><span>LA-ICP-MS).</span></p> <p><span>We demonstrate that the OSL sensitisation results as an effect of the existence of certain defects and impurities in the quartz crystal in the parent rock, such as titanium and germanium. However, the degree of sensitisation reached in nature is significantly higher than in the laboratory. <span> </span>As such, the existence of this precursor represents the potential for sensitisation, which can later be amplified by environmental factors during sedimentary history.</span></p>
Data from: Kir2.1 modulation in macrophages sensitises dorsal root ganglion neurons through TNF secretion after nerve injury
<p>This data pertain to the manuscript titled "Kir2.1 modulation in macrophages sensitises dorsal root ganglion neurons through TNF secretion after nerve injury", currently in preprint on BioRxiv (https://doi.org/10.1101/2023.06.21.545843). The name of the data files correspond to the for each figure in the study. The data file in .csv format are organized so that they can easily be opened in R or other analysis language. To understand them and how they are labelled, it is advised to open the figure next to them and find the appropriate panel.</p> <p>Here are included:</p> <ul> <li>Example images of section of mouse dorsal root ganglion (DRG) after spared nerve injury (SNI), labelled for CX3CR1+ cells, Ki67 and MHC class II by immunohistochemistry.</li> <li>LC-MS-MS proteomic data set of CX3CR1+ cells from DRG of mice after SNI.</li> <li>Voltage clamp data of CX3CR1+ cells from DRG of mice after SNI</li> <li>Electrophysiological data sets (multi-electrode array, current clamp and voltage clamp) of dissociated DRG neurons treated with medium conditioned by CX3CR1+ or GFAP+ cells sorted from ipsilateral or contralateral DRG from mice after SNI. In addition, pharmacological treatments were added to the conditioned medium (CM).</li> </ul>
Supporting data and libraries used for statistical analysis for the article: "Targeted metabolomic profiling reveals differences in plasma metabolome of ovalbumin sensitised guinea pigs"
<p>Supporting data and libraries used for statistical analysis for the article: "Targeted metabolomic profiling reveals differences in plasma metabolome of ovalbumin sensitised guinea pigs"</p>
D-0316 Versus Icotinib in Patients With Locally Advanced or Metastatic EGFR Sensitising Mutation Positive NSCLC
ClinicalTrials.gov study NCT04206072. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
ClinicalTrials.gov study NCT05753930. IPD Sharing: NO. Countries: 4. Publications: 1.
Skin Sensitisation (Modified Draize-95 Test)
ClinicalTrials.gov study NCT04402476. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Risk of Sensitisation of the rdESAT-6 + rCFP-10 Skin Test Following Repeated Intradermal Administration
ClinicalTrials.gov study NCT00793702. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Central Sensitisation in Nociceptive and Neuropathic Pain
ClinicalTrials.gov study NCT07321080. IPD Sharing: NO. Countries: 1. Publications: 0.
To Evaluate Skin Irritation and Skin Sensitisation of Developmental Cosmetic Facial Products
ClinicalTrials.gov study NCT04007159. IPD Sharing: YES. Countries: 1. Publications: 0.
RNA Polymerase IV sensitises the chromatin via histone modifications modulating protein coding genes [RNA-Seq]
GEO Series GSE180335. Oryza sativa. 8 samples. Type: Expression profiling by high throughput sequencing.
RNA Polymerase IV sensitises the chromatin via histone modifications modulating protein coding genes [sRNA-Seq]
GEO Series GSE180456. Oryza sativa. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNA Polymerase IV sensitises the chromatin via histone modifications modulating protein coding genes
GEO Series GSE180457. Oryza sativa. 50 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
CRISPR/Cas9 genome-wide screens for sensitisers and suppressors of AZD6738 efficacy in Atm WT and Atm KO mESCs
<p>The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours harbouring mutations in the related kinase ATM. However, it still remains unclear which functions and pathways dominate long-term ATRi efficacy, and how these vary between clinically relevant genetic backgrounds. Elucidating common and genetic-background specific mechanisms of ATRi efficacy could therefore assist patient stratification and pre-empting drug resistance. Here, we use CRISPR-Cas9 genome-wide screening in ATM-deficient and proficient mouse embryonic stem cells to interrogate cell fitness following treatment with the ATRi, ceralasertib (AZD6738). We identify factors that enhance or suppress ATRi efficacy, with a subset of these requiring intact ATM signalling. Overall, our work identifies novel biomarkers of ATRi efficacy in ATM-proficient and ATM-deficient cells, and suggests new ATM-dependent pathways that compensate in the absence of functional ATR.</p>
poSt Covid-19 Infection centraL sENsitisaTion
ClinicalTrials.gov study NCT04703452. IPD Sharing: Not stated. Countries: 1. Publications: 0.
TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations
ClinicalTrials.gov study NCT05407012. IPD Sharing: NO. Countries: 1. Publications: 0.
GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation
ClinicalTrials.gov study NCT01291316. IPD Sharing: Not stated. Countries: 1. Publications: 0.
poSt Covid-19 Infection centraL Sensitisation 2
ClinicalTrials.gov study NCT04701892. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of Pain, Sensitisation, Function and Quality of Life According to Stenosis Degree in Chronic Neck Pain
ClinicalTrials.gov study NCT06967415. IPD Sharing: NO. Countries: 1. Publications: 0.
Central Sensitisation in Patients With Haemophilia and Degenerative Arthropathy
ClinicalTrials.gov study NCT07110675. IPD Sharing: NO. Countries: 1. Publications: 0.
Grass Sensitisation and Allergic Rhinitis in Thai Patients
ClinicalTrials.gov study NCT01686022. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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