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37 results for “sequence space”
Sequence data for 'Machine-driven parameter-space exploration of biochemical reactions'
<p>The development of complex, multi-step <em>omics</em> methods in molecular biology is a laborious, costly, iterative and often intuition-bound process where an optimum is sought in a parameter space through step-by-step optimisations. The the difficulty of miniaturising assays and the cost of the experiments limit the dynamic range and the number of parameters that can be explored. However, because of non-linearities of the response of biochemical systems to their reagent concentrations, a broad dynamic range is necessary. Here we demonstrate the use of a high-performance nanoliter handling platform (Labcyte Echo 525) and computer generation of liquid transfer programs to explore in quadruplicates more than 600 combination of 4 parameters of a biochemical reaction, which lead us to uncover non-linear responses, parameter interactions and novel mechanical insights. With the increased availability of « <em>cloud biology</em>» computer-driven laboratory platforms, our results participate in changing methods development for biotechnology towards reproducible, computer-aided exhaustive characterisation of biochemical systems.</p> <p>This dataset contains the raw sequencing data produced with an Illumina MiSeq instrument for this project. FASTQ files and sample sheets are found in the usual location (Data/Intensities/BaseCalls). The "Thumbnail_Images" and "L001" directories were deleted to save space.</p> <p>Run IDs: 171227_M00528_0321_000000000-B4GLP, 180403_M00528_0348_000000000-B4GP8, 180517_M00528_0364_000000000-BRGK6, 180123_M00528_0325_000000000-B4PCK, 180411_M00528_0351_000000000-BN3BL, 180606_M00528_0367_000000000-BN3FG, 180326_M00528_0346_000000000-B4GJR, 180501_M00528_0359_000000000-B4PJY, 180607_M00528_0368_000000000-BN9KM</p> <p> </p>
Data from: Latent generative landscapes as maps of functional diversity in protein sequence space
<p>Variational autoencoders are unsupervised learning models with generative capabilities, when applied to protein data, they classify sequences by phylogeny and generate de novo sequences which preserve statistical properties of protein composition. While previous studies focus on clustering and generative features, here, we evaluate the underlying latent manifold in which sequence information is embedded. To investigate properties of the latent manifold, we utilize direct coupling analysis and a Potts Hamiltonian model to construct a latent generative landscape. We showcase how this landscape captures phylogenetic groupings, functional and fitness properties of several systems including Globins, β-lactamases, ion channels, and transcription factors. We provide support on how the landscape helps us understand the effects of sequence variability observed in experimental data and provides insights on directed and natural protein evolution. We propose that combining generative properties and functional predictive power of variational autoencoders and coevolutionary analysis could be beneficial in applications for protein engineering and design.</p>
Data from: Latent generative landscapes as maps of functional diversity in protein sequence space
Open the record for dataset details and reuse information.
Branching Trees from standard Epidemic Aftershock Sequences (ETAS) Model (no time, no space)
<p>All files licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)</p> <p>###############<br> 0. SUMMARY<br> ###############</p> <p>1. DESCRIPTION</p> <p>2. INPUT PARAMETERS</p> <p>3. TYPES OF FILES<br> 3.1. Raw data<br> 3.2. List of trees<br> 3.3. Tree-size frequencies</p> <p>4. LIST OF FILES<br> 4.1. Raw data<br> 4.2. List of trees<br> 4.3. Tree-size frequencies<br> 4.4 Known missing/broken files</p> <p>###############<br> 1. DESCRIPTION<br> ################<br> Simulation results of an standard ETAS model as a branching process. Using a two seed version of the RANDU linear congruential pseudorandom number generator. The offspring number is a Poisson number given the rate n(M) (see below). Details of simulation procedure can be found in reference [1]: 'Topological properties of epidemic aftershock processes', by J. Baró submitted to J. of Geophysical Research - Solid Earth (JGR-B)</p> <p>##############<br> 2. INPUT PARAMETERS<br> ##############<br> The input parameters (see reference for details) for each raw and processes data-file are indicated in the prefix of the file: "ETASbranch_b(b)r(r)N(nb)*"</p> <p>- M0(= 1) = magnitude of completeness (arbitrary for the study of topological properties of trees)<br> - (b) = b-value (arbitrary for the study of topological properties of trees)<br> - (nb) = average branching ratio<br> - (r) = ratio a/b</p> <p>The b-value defines the distribution of event-magnitudes: P(M) = 10^(b*(M-M0)) . The nb and a define the productivity law: n(M) = (nb*(b-a)/b)*10^(a*(M-M0))</p> <p><br> #################<br> 3. TYPES OF FILES<br> #################</p> <p>3.1. Raw data:<br> --------------</p> <p>42 x "*.Seq" files with input b=0.50 and different nb, r values. Raw data from simulation code. (all cases, simulated with 10^5 background events)<br> Each row represents an individual event in the point process, or element of the simulated branching forest.<br> Columns description (9 columns x data point):<br> c0:Time (arbitrary, used here as id.)<br> c1:Magnitude of the event<br> c2:Identification number of the cluster or tree<br> c3:Depth of the event in the tree structure (background events have Depth = 0)<br> c4:Time of the direct parent of the event (set to -1 for background event)<br> c5:Magnitude of the direct parent of the event (set to -10 if background event)<br> c6:Time of the event initiating the tree (set to own time if background)<br> c7:Magnitude of the event initiating the tree (set to own magnitude if background)<br> c8:N or offspring number of the event. (Events are leafs if N=0)</p> <p><br> 3.2. List of trees<br> ------------------</p> <p>53 x "*TopoTrees.dat" files obtained from simulations (after processing of *.Seq files. Files ending with "N0.99", "N0.50" obtained from 10^5 background events from files above. Files ending with "N0.500*" obtained from 10^7 simulations)<br> Each row represents an individual tree constituted by one or several causally connected events of the simulated branching forest. Files used to generate fig. 4 of ref. [1]</p> <p>Columns description (8 columns x data point):<br> c0:Maximum Depth of the tree<br> c1:Number of events in the tree<br> c2:Average depth of leaves<br> c3:total number of leaves<br> c4:Sum of the depth of all leaves (=c2*c3)<br> c5:(=0) not used<br> c6:Magnitude of root<br> c7:Maximum magnitude of an event inside the tree</p> <p><br> 4.3. Tree-size frequencies<br> --------------------------</p> <p>18 x "*TopoTrees.FK" files obtained from "*TopoTrees.dat". Contains the frequencies of tree-sizes. Each raw number correspond to a size. Each value corresponds to number of incidences of that size divided by total number of events (10^5 in all cases). Notice that last point is missing at size = max-length, freq.= 1.0 / total number of events. Files used to generate fig. 3 of ref. [1]</p> <p><br> ################<br> 4. LIST OF FILES<br> ################</p> <p>(copy of this text)<br> readme.txt<br> md5:2073cdbb4a0afd8ab96f8bfaef20579f 13 Kb</p> <p>4.1. Raw data (42 files)<br> ------------------------</p> <p>ETASbranch_b0.50r0.00N0.50.Seq<br> md5:bae21678db4fe575b06b69a5f32253d2 12.5 Mb<br> ETASbranch_b0.50r0.00N0.99.Seq<br> md5:76ea70ba94aeeed7ba3c358305f4b85b 1.3 Gb<br> ETASbranch_b0.50r0.05N0.50.Seq<br> md5:0ccf5af07efb9dd99d63a9675fd3069f 12.4 Mb<br> ETASbranch_b0.50r0.05N0.99.Seq<br> md5:77a7bfd490af54a5a3d15c4183e9e6f7 1.4 Gb<br> ETASbranch_b0.50r0.10N0.50.Seq<br> md5:f274717039f8f69ce57d5054577777af 12.4 Mb<br> ETASbranch_b0.50r0.10N0.99.Seq<br> md5:e18f4c26acfdff8d79a6223aa86867d2 1.3 Gb<br> ETASbranch_b0.50r0.15N0.50.Seq<br> md5:5f93c14a8d0f88fd021bc6d8a5fc7d6e 12.3 Mb<br> ETASbranch_b0.50r0.15N0.99.Seq<br> md5:906e09ecb6c6c18fdbcfdca3d9dbe225 1.3 Gb<br> ETASbranch_b0.50r0.20N0.50.Seq<br> md5:2467c2c7fafeddaa630074e991cb7767 12.4 Mb<br> ETASbranch_b0.50r0.20N0.99.Seq<br> md5:64c45a47b7f953d7088b10d4badd068c 1.3 Gb<br> ETASbranch_b0.50r0.25N0.50.Seq<br> md5:d65abaa4664b2412707b27b6e9143215 12.4 Mb<br> ETASbranch_b0.50r0.25N0.99.Seq<br> md5:8d7467b0bd80ce7e8cbcaf5dfe2725b7 1.2 Gb<br> ETASbranch_b0.50r0.30N0.50.Seq<br> md5:fd3af9802b3b66a623172bb2aafc0a0b 12.4 Mb<br> ETASbranch_b0.50r0.30N0.99.Seq<br> md5:2ad1b9b9c858638067af6068dfd25d59 1.3 Gb<br> ETASbranch_b0.50r0.35N0.50.Seq<br> md5:8cf36cc90a19f1283c838dee4849626b 12.5 Mb<br> ETASbranch_b0.50r0.35N0.99.Seq<br> md5:6b35085100561865ac9463edfb166d7f 1.4 Gb<br> ETASbranch_b0.50r0.40N0.50.Seq<br> md5:317b154c8ed74262b18c41762597d236 12.3 Mb<br> ETASbranch_b0.50r0.40N0.99.Seq<br> md5:c83dc299035928c9ae8a7f6d101ac9b8 1.2 Gb<br> ETASbranch_b0.50r0.45N0.50.Seq<br> md5:d3baccfbf347e555c30f3dfb1db1d9c0 12.4 Mb<br> ETASbranch_b0.50r0.45N0.99.Seq<br> md5:5bf42163acc2eae1eeae8549b850ccc9 1.1 Gb<br> ETASbranch_b0.50r0.50N0.50.Seq<br> md5:3ad7427725dfcf302c2dc2c519dad8c0 12.4 Mb<br> ETASbranch_b0.50r0.50N0.99.Seq<br> md5:7316fb3661b87215a1a7b1c11a54975b 1.3 Gb<br> ETASbranch_b0.50r0.55N0.50.Seq<br> md5:6dbc9846506675c61d110ae918165a6b 12.4 Mb<br> ETASbranch_b0.50r0.55N0.99.Seq<br> md5:5d4d007bf898512185dd2f87b715715e 1.4 Gb<br> ETASbranch_b0.50r0.60N0.50.Seq<br> md5:569c1c409ef618f518fe6fb6f41493a3 12.7 Mb<br> ETASbranch_b0.50r0.60N0.99.Seq<br> md5:e739613598e8d2530d108ff24e8c045a 1.1 Gb<br> ETASbranch_b0.50r0.65N0.50.Seq<br> md5:e95cead475c1eedb0618bebf1b548ec2 12.3 Mb<br> ETASbranch_b0.50r0.65N0.99.Seq<br> md5:8fe8b042085f261971d94bf12f96dc7e 1 Gb<br> ETASbranch_b0.50r0.70N0.50.Seq<br> md5:48824f1efdbc31c5bb4d4f799bc166d5 12.2 Mb<br> ETASbranch_b0.50r0.70N0.99.Seq<br> md5:2ead803394a4c3b04f1e22e9b8c5ba46 872.9 Mb<br> ETASbranch_b0.50r0.75N0.50.Seq<br> md5:8c5cf4753836076c677a74d831354f33 12.2 Mb<br> ETASbranch_b0.50r0.75N0.99.Seq<br> md5:91ed931aedfb365761799e0882fcfb86 1 Gb<br> ETASbranch_b0.50r0.80N0.50.Seq<br> md5:f93e1779bc5344ffd17021bb387bb373 11 Mb<br> ETASbranch_b0.50r0.80N0.99.Seq<br> md5:6b0fd7fcad20ac4467fecda9502e9954 75.6 Mb<br> ETASbranch_b0.50r0.85N0.50.Seq<br> md5:a5debe21de70204a490c75dd7c68657a 11 Mb<br> ETASbranch_b0.50r0.85N0.99.Seq<br> md5:f9ed3ad6db12ad4a612c3945ccf72f18 48.5 Mb<br> ETASbranch_b0.50r0.90N0.50.Seq<br> md5:4493eef2170b68052cf56636c63091d7 9.7 Mb<br> ETASbranch_b0.50r0.90N0.99.Seq<br> md5:70043ed6c84e3896268c46f77eabefd3 26.7 Mb<br> ETASbranch_b0.50r0.95N0.50.Seq<br> md5:874916faa95c63312aa27aecea45de8f 7.5 Mb<br> ETASbranch_b0.50r0.95N0.99.Seq<br> md5:bbc54464c2e3cbac64401978216ae993 11.7 Mb<br> ETASbranch_b0.50r1.00N0.50.Seq<br> md5:3ff467b894f46a4be0b0747c686edad5 5.8 Mb<br> ETASbranch_b0.50r1.00N0.99.Seq<br> md5:d4d5416d56ed3de6eb2702a8eeb0a0b5 5.8 Mb</p> <p><br> 3.2. List of trees (53 files)<br> -----------------------------</p> <p><br> ETASbranch_b1.00r0.00N0.500TopoTrees.dat<br> md5:a5834b8d047fd3446e6d83488422bb5b 1.8 Gb<br> ETASbranch_b1.00r0.00N0.99TopoTrees.dat<br> md5:34eb899782444475151073ed6fcfc6aa 18.6 Mb<br> ETASbranch_b1.00r0.05N0.50TopoTrees.dat<br> md5:cc5f0edfc31a5f15394444243560e0ad 18.6 Mb<br> ETASbranch_b1.00r0.05N0.99TopoTrees.dat<br> md5:58cc7e7e746051f9efbe510c164a2b09 18.6 Mb<br> ETASbranch_b1.00r0.10N0.500TopoTrees.dat<br> md5:52cb3a9a5aeb1e222743bcdad3ea3b3d 1.8 Gb<br> ETASbranch_b1.00r0.10N0.50TopoTrees.dat<br> md5:a68a69280c0129ee3554d5c97dd0fa47 18.6 Mb<br> ETASbranch_b1.00r0.10N0.99TopoTrees.dat<br> md5:307edf1353af5141f11d89cbab6c4d30 18.6 Mb<br> ETASbranch_b1.00r0.15N0.500TopoTrees.dat<br> md5:52807004c32bdc1a999a2aaf1ff91bb9 1.8 Gb<br> ETASbranch_b1.00r0.15N0.50TopoTrees.dat<br> md5:0bdb45b13ed0fd5c0fa1619310d71670 18.6 Mb<br> ETASbranch_b1.00r0.15N0.99TopoTrees.dat<br> md5:f26e351184921ed9a85c8993404a4718 18.6 Mb<br> ETASbranch_b1.00r0.20N0.500TopoTrees.dat<br> md5:5fd930a98e28d551c9c204d22c6f564a 1.8 Gb<br> ETASbranch_b1.00r0.20N0.50TopoTrees.dat<br> md5:4aaeb952e0ecb7d4fc4bd2fb7822c729 18.6 Mb<br> ETASbranch_b1.00r0.20N0.99TopoTrees.dat<br> md5:a30687662b269f447d7e4cc020bd3773 18.6 Mb<br> ETASbranch_b1.00r0.25N0.500TopoTrees.dat<br> md5:4168e6e70b247977213d2278b94d65f3 1.8 Gb<br> ETASbranch_b1.00r0.25N0.50TopoTrees.dat<br> md5:b360877be00088b52676ba4717377761 18.6 Mb<br> ETASbranch_b1.00r0.25N0.99TopoTrees.dat<br> md5:34d11b64c78c852d4f50de7b1265c9b7 18.6 Mb<br> ETASbranch_b1.00r0.30N0.500TopoTrees.dat<br> md5:8c1a8b07c5f2350646d415a687f84492 1.8 Gb<br> ETASbranch_b1.00r0.30N0.50TopoTrees.dat<br> md5:0c1bfccd8cd141090a0bfb0cc7ae1ccd 18.6 Mb<br> ETASbranch_b1.00r0.30N0.99TopoTrees.dat<br> md5:652f975754241fed317acba066cf339b 18.6 Mb<br> ETASbranch_b1.00r0.35N0.500TopoTrees.dat<br> md5:6bc2a3f7b4f7fd8a92595271d2ea425f 1.8 Gb<br> ETASbranch_b1.00r0.35N0.50TopoTrees.dat<br> md5:d1d4e8a467d8d445cd3f6ca27c3c8af3 18.6 Mb<br> ETASbranch_b1.00r0.35N0.99TopoTrees.dat<br> md5:e56eee0119b193898ea729b75c572617 18.6 Mb<br> ETASbranch_b1.00r0.40N0.500TopoTrees.dat<br> md5:370a2f6c670fd7c9b515e43891417b73 1.8 Gb<br> ETASbranch_b1.00r0.40N0.50TopoTrees.dat<br> md5:9f50c23e33cca983df58e2b17f29f8e5 18.6 Mb<br> ETASbranch_b1.00r0.40N0.99TopoTrees.dat<br> md5:d9971930b46838de09a7ccdc7cd9b459 18.6 Mb<br> ETASbranch_b1.00r0.45N0.500TopoTrees.dat<br> md5:cfef99746043d0718ad19e48ffdfeee4 1.8 Gb<br> ETASbranch_b1.00r0.45N0.50TopoTrees.dat<br> md5:44667f56360024e40b11be4f52ccf9c3 18.6 Mb<br> ETASbranch_b1.00r0.45N0.99TopoTrees.dat<br> md5:09b84c6f3c9dd58331c6f9ab4eec8f58 18.6 Mb<br> ETASbranch_b1.00r0.50N0.500TopoTrees.dat<br> md5:e9e880f24ffc9ba40db7c7f78d0f8d89 1.8 Gb<br> ETASbranch_b1.00r0.50N0.50TopoTrees.dat<br> md5:ce4835d532513bffd54723f285207898 1.9 Mb<br> ETASbranch_b1.00r0.50N0.99TopoTrees.dat<br> md5:4c935d76aee113c88f4a3348197f75f3 18.6 Mb<br> ETASbranch_b1.00r0.55N0.500TopoTrees.dat<br> md5:46cd9e8d508c15009e90a194a141008f 1.8 Gb<br> ETASbranch_b1.00r0.55N0.50TopoTrees.dat<br> md5:8e1cb9c364c2a275d10373b54dab6239 18.6 Mb<br> ETASbranch_b1.00r0.55N0.99TopoTrees.dat<br> md5:304b947c52e826a9b4cb68c38f007443 18.6 Mb<br> ETASbranch_b1.00r0.60N0.500TopoTrees.dat<br> md5:df8b7889e76694188b29f7fc16f6dce2 1.8 Gb<br> ETASbranch_b1.00r0.60N0.50TopoTrees.dat<br> md5:fc6c2110e139290ae9401765e8aae782 18.6 Mb<br> ETASbranch_b1.00r0.60N0.99TopoTrees.dat<br> md5:6af466cc527b7422f1f958bfc6a87d15 18.6 Mb<br> ETASbranch_b1.00r0.65N0.500TopoTrees.dat<br> md5:129abd6de7821da465265a485217156d 1.8 Gb<br> ETASbranch_b1.00r0.65N0.50TopoTrees.dat<br> md5:469fc2ae3768fe9ae0ab0b8fbfaf3051 18.6 Mb<br> ETASbranch_b1.00r0.65N0.99TopoTrees.dat<br> md5:b7148c414b243b1911de8543d25e3d38 18.6 Mb<br> ETASbranch_b1.00r0.70N0.500TopoTrees.dat<br> md5:3a3eed181ae6308c29f274d5e14a97df 1.8 Gb<br> ETASbranch_b1.00r0.70N0.50TopoTrees.dat<br> md5:ca7472f17916e7f8634a97c08ca96c58 18.6 Mb<br> ETASbranch_b1.00r0.70N0.99TopoTrees.dat<br> md5:8c2a4ab3800e8a8178be5d6e856f5b50 18.6 Mb<br> ETASbranch_b1.00r0.75N0.50TopoTrees.dat<br> md5:374796f34a3e25f711601161f8a34ae7 18.6 Mb<br> ETASbranch_b1.00r0.75N0.99TopoTrees.dat<br> md5:591f6ac31545f3e7558b4a5e151c80a5 18.6 Mb<br> ETASbranch_b1.00r0.80N0.50TopoTrees.dat<br> md5:473c6e9ac33cc6e8eabe0ed3c91b40b7 18.6 Mb<br> ETASbranch_b1.00r0.80N0.99TopoTrees.dat<br> md5:81f41fbce89c931f87890133b4c0f9f9 18.6 Mb<br> ETASbranch_b1.00r0.85N0.50TopoTrees.dat<br> md5:2c38db4208898d95c1c5b2ef0a94c930 18.6 Mb<br> ETASbranch_b1.00r0.85N0.99TopoTrees.dat<br> md5:4866f179b52ff5a6191d47e6d8ead5ce 18.6 Mb<br> ETASbranch_b1.00r0.90N0.50TopoTrees.dat<br> md5:f14a7f700c0c73743eb5747399abdcce 18.6 Mb<br> ETASbranch_b1.00r0.90N0.99TopoTrees.dat<br> md5:da4bd00aeefcbd1e67f0d7fe8fb1d8be 18.6 Mb<br> ETASbranch_b1.00r0.95N0.50TopoTrees.dat<br> md5:57b7f0bd901bb47ba3c253f801301716 18.6 Mb<br> ETASbranch_b1.00r0.95N0.99TopoTrees.dat<br> md5:6381354768603c6d2129c99df2a7798a 18.6 Mb</p> <p>4.3. Tree-size frequencies (18 files)<br> -------------------------------------</p> <p>ETASbranch_b1.00r0.00N0.99TopoTrees.FK<br> md5:5b6ccaf1c1218f101ed24c332bfefec3 612 Kb<br> ETASbranch_b1.00r0.10N0.30TopoTrees.FK<br> md5:f9f07bbd7be5377e1589101e85640149 468 B<br> ETASbranch_b1.00r0.20N0.30TopoTrees.FK<br> md5:6c7e40f8b93c7a3e62f2c105f0e7a89b 558 B<br> ETASbranch_b1.00r0.20N0.99TopoTrees.FK<br> md5:158884c9bc4afa10c8ebb2e7b516a421 3.3 Mb<br> ETASbranch_b1.00r0.30N0.30TopoTrees.FK<br> md5:14d837b9763b9a54e64311e832e29f04 846 B<br> ETASbranch_b1.00r0.30N0.99TopoTrees.FK<br> md5:90b8b5a38a83cb4b4c833b605cf6b38e 2.1 Mb<br> ETASbranch_b1.00r0.40N0.30TopoTrees.FK<br> md5:1f198a7c08078066e7fa57ce9ebda8eb 3 Kb<br> ETASbranch_b1.00r0.40N0.99TopoTrees.FK<br> md5:229b837e7950fe85ea1c51be8e3f457e 3.3 Mb<br> ETASbranch_b1.00r0.50N0.30TopoTrees.FK<br> md5:6ead8bff09c3c2687c526648bfec6ab3 16 Kb<br> ETASbranch_b1.00r0.60N0.30TopoTrees.FK<br> md5:38c5cb9f544367ff9bdab766c4bcf03f 112 Kb<br> ETASbranch_b1.00r0.60N0.99TopoTrees.FK<br> md5:2591d4e2dd1c2051c0b7d96f423c526a 106.5 Mb<br> ETASbranch_b1.00r0.70N0.30TopoTrees.FK<br> md5:4f7741314e1a0d0b1c1733532d909277 7.5 Mb<br> ETASbranch_b1.00r0.80N0.30TopoTrees.FK<br> md5:3c4240e79ee19c03afac91d631f38cb8 602 Kb<br> ETASbranch_b1.00r0.80N0.30TopoTrees.FK<br> md5:3c4240e79ee19c03afac91d631f38cb8 602 Kb<br> ETASbranch_b1.00r0.90N0.30TopoTrees.FK<br> md5:914a782fa2e73c0bc5a6e70bbb2afec9 1.3 Mb<br> ETASbranch_b1.00r0.90N0.99TopoTrees.FK<br> md5:cc165045d4d9f25c0f9c30c0ec71759f 864 Kb<br> ETASbranch_b1.00r0.99N0.30TopoTrees.FK<br> md5:a08cfc27a0e42d54f207ea05b7210714 187 Kb<br> ETASbranch_b1.00r0.99N0.99TopoTrees.FK<br> md5:a15681be56f870a95fe62794b11524df 365 Kb</p> <p><br> 4.4 Known missing/broken files<br> ------------------------------</p> <p>ETASbranch_b1.00r0.50N0.50TopoTrees.dat<br> ETASbranch_b1.00r0.10N0.99TopoTrees.FK<br> ETASbranch_b1.00r0.20N0.99TopoTrees.FK<br> ETASbranch_b1.00r0.50N0.99TopoTrees.FK<br> ETASbranch_b1.00r0.70N0.99TopoTrees.FK<br> ETASbranch_b1.00r0.05N0.500TopoTrees.dat<br> ETASbranch_b1.00r0.70N0.500TopoTrees.dat<br> ETASbranch_b1.00r0.75N0.500TopoTrees.dat<br> ETASbranch_b1.00r0.80N0.500TopoTrees.dat<br> ETASbranch_b1.00r0.85N0.500TopoTrees.dat<br> ETASbranch_b1.00r0.90N0.500TopoTrees.dat<br> ETASbranch_b1.00r0.95N0.500TopoTrees.dat<br> </p>
ABodyBuilder2 predicted structures of paired antibody sequences from Observed Antibody Space.
<p>We used ABodyBuilder2 (https://doi.org/10.1038/s42003-023-04927-7) to model ~1.5M paired antibody structures from paired antibody sequences in Observed Antibody Space (https://opig.stats.ox.ac.uk/webapps/oas/oas_paired/). We have save the structures in folders and sub folders that correspond to the OAS files they came from. Parent folders are named according to study. Within each parent folder are sub folders names according to the files (named by SRA ID) containing sequences. Each structure is then named with the parent file followed by the row number from this file.</p>
Single-molecule structural and kinetic studies across sequence space
<p>Data and analysis code related to the research article:</p> <p>Single-molecule structural and kinetic studies across sequence space</p>
Respiratory-triggered MRCP acquisition at 3T using a T2-weighted TSE (3D SPACE) sequence for Deep Learning-based reconstruction of MRCP
<h1>Description</h1> <p>This dataset is the sample data for MRCP_DLRecon (<a href="https://github.com/JinhoKim46/MRCP_DLRecon">GitHub</a>). <br>Place this dataset in the "Sample_data/" directory along with the "dataset.csv" file. </p> <h1>Data</h1> <p>The provided 3D MRCP data were acquired at 3T (Skyra, Siemens Healthineers AG, Erlangen) using the 3D-SPACE (3D T2w TSE) sequence for a single healthy volunteer. We provide two 2x and one 6x 3D MRCP data to ensure various training and testing scenarios. Each data in the HDF5 format contains the following structures:</p> <ul> <li>Datasets <ul> <li><strong>grappa</strong>: target data (y * x *<em> </em>slice)</li> <li><strong>kdata_raw</strong>: Raw <em>k</em>-space data (x2 or x6) (nCoil * PE * RO * slice)</li> <li><strong>kdata_fs</strong>: Fully-sampled k-space data from <strong>kdata_raw</strong> using GRAPPA (nCoil ×× PE ×× RO ×× Slice)</li> <li><strong>sm_espirit</strong>: ESPIRiT-based sensitivity maps (nCoil * y * x * slice)</li> </ul> </li> </ul> <h1>Citation</h1> <p>Please cite the following <a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.70002" target="_blank" rel="noopener">paper</a> if this dataset is helpful for your research :)</p> <blockquote> <p>Kim, J., Nickel, M. and Knoll, F. (2025), Deep Learning-Based Accelerated MR Cholangiopancreatography Without Fully-Sampled Data. NMR in Biomedicine, 38: e70002. https://doi.org/10.1002/nbm.70002 </p> </blockquote>
Raw k-space data for free-breathing diffusion weighted sequence
Open the record for dataset details and reuse information.
Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence
ClinicalTrials.gov study NCT03303365. IPD Sharing: NO. Countries: 1. Publications: 21.
Data from: Prediction accuracies for growth and wood attributes of interior spruce in space using genotyping-by-sequencing
Open the record for dataset details and reuse information.
Supplementary dataset for Expanded sequence space of radical S-adenosylmethionine-dependent enzyme involved in post-translational macrocyclization
<p>Supplementary dataset for <a href="https://www.researchsquare.com/article/rs-1789925/v1">Expanded sequence space of radical S-adenosylmethionine-dependent enzyme involved in post-translational macrocyclization</a></p> <p>Supporting Information Dataset 1: Logo sequences of 500 clusters in precursor SSN.</p> <p>Supporting Information Dataset 2: 199 cyclophane precursor from actinobacteria</p> <p>Supporting Information Dataset 3: Distribution of different enzymes adjacent to small peptides</p> <p>Supporting Information Dataset 4: Cross-comparison analysis of antiSMASH and PRISM-RiPP-predicted rSAM maturase</p> <p>Supporting Information Dataset 5: mmseq2 output of all identified precursors.</p>
FORAlign: Accelerating gap-affine DNA pairwise sequence alignment using FOR-blocks based on FOur Russians approach with linear space complexity
Open the record for dataset details and reuse information.
Data from: Viral tagging reveals discrete populations in Synechococcus viral genome sequence space
Open the record for dataset details and reuse information.
['"Draft Genome Sequences of Members of the family Methylobacteriaceae Associated with the International Space Station"']
['"Draft Genome Sequences of isolates belonging to family Methylobacteriaceae Isolated from the International Space Station"']
['Draft Genome Sequences of Two Fusarium oxysporum Isolates Cultured from Infected Zinnia hybrida Plants Grown on the International Space Station']
['Draft genome sequences of two Fusarium oxysporum isolates cultured from infected Zinnia hybrida plants grown on the International Space Station']
['Draft Genome Sequence of Solibacillus kalamii, Isolated from an Air Filter Aboard the International Space Station']
['Solibacillus kalamii was isolated from a HEPA filter in the International Space Station. This strain was of particular interest due to the unique environment in which it was isolated from.']
ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells
GEO Series GSE74757. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Engineering orthogonal signaling pathways reveals the sparse distribtion of protein protein interactions in sequence space [RNA-seq]
GEO Series GSE128611. Escherichia coli str. K-12 substr. MG1655. 20 samples. Type: Expression profiling by high throughput sequencing.
Engineering orthogonal signaling pathways reveals the sparse distribtion of protein protein interactions in sequence space [degenerate_library_sort_seq]
GEO Series GSE120780. Escherichia coli str. K-12 substr. MG1655. 56 samples. Type: Other.
Expanding the transcriptomic sequence space in leukaemia by RUNX1/RUNX1T1-mediated alternative splicing
GEO Series GSE160792. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.