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Dataset results
16 results for “serotonergic system”
Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring
<p>Increasingly, studies are revealing that endocrine disrupting chemicals (EDCs) can alter animal behavior. Early life exposure to EDCs may permanently alter phenotypes through to adulthood. In addition, the effects of EDCs may not be isolated to a single generation − offspring may indirectly be impacted, via non-genetic processes. <span class="fontstyle01"><span>Here, we analyzed the effects of paternal atrazine exposure on behavioral traits (distance moved, exploration, bottom-dwelling time, latency to enter the top zone, and interaction with a mirror) and whole-brain mRNA of genes involved in the serotonergic system regulation (</span></span><span class="fontstyle01"><span><i>slc6a4a</i></span></span><span class="fontstyle01"><span>, </span></span><span class="fontstyle01"><span><i>slc6a4b</i></span></span><span class="fontstyle01"><span>, </span></span><span class="fontstyle01"><span><i>htr1Aa</i></span></span><span class="fontstyle01"><span>, </span></span><span class="fontstyle01"><span><i>htr1B</i></span></span><span class="fontstyle01"><span>, </span></span><span class="fontstyle01"><span><i>htr2B</i></span></span><span class="fontstyle01"><span>) of zebrafish (</span></span><span class="fontstyle01"><span><i>Danio rerio</i></span></span><span class="fontstyle01"><span>). F0 male zebrafish were exposed to atrazine at 0.3, 3 or 30 part per billion (ppb) during early juvenile development, the behavior of F1 progeny was tested at adulthood, and the effect of 0.3 ppb atrazine treatment on mRNA transcription was quantified. Paternal exposure to atrazine significantly reduced interactions with a mirror (a proxy for aggression) and altered the latency to enter the top zone of a tank in unexposed F1 offspring. Bottom-dwelling time (a proxy for anxiety) also appeared to be somewhat affected, and activity (distance moved) was reduced in the context of aggression. </span></span><span class="fontstyle01"><span><i>slc6a4a </i></span></span><span class="fontstyle01"><span>and </span></span><span class="fontstyle01"><span><i>htr1Aa</i></span></span><span class="fontstyle01"><span> mRNA transcript levels were found to correlate positively with anxiety levels in controls, but we found that this relationship was disrupted in the 0.3 ppb atrazine treatment group. Overall, paternal atrazine exposure resulted in alterations across a variety of behavioral traits and showed signs of serotonergic system dysregulation, demonstrating intergenerational effects. Further research is needed to explore transgenerational effects on behavior and possible mechanisms underpinning behavioral effects. </span></span></p>
Periprandial changes in brain serotonergic system and food intake related neuropeptides
<p><span>In this work, we assessed periprandial serotonin and 5-hydroxyindolacetic acid abundance in several brain areas of rainbow trout, in parallel with the evaluation of gene expression of tryptophan hydroxilase 1 and 2, neuropeptides involved in the central control of food intake, and the quantification of plasma glucose and cortisol. The results showed severe changes in serotonergic systems around mealtime, the most prominent being the increase in their activity just after food intake, suggesting that serotonin has a relevant role in relation to the daily timing of food intake, probably triggering satiety signals. In addition, a temporal adjustment of neuropeptide expression and plasma cortisol was found in relation to food intake, supporting its role in the regulation of feeding behaviour.</span></p>
Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring
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Periprandial changes in brain serotonergic system and food intake related neuropeptides
Open the record for dataset details and reuse information.
Effects of Hormone Replacement Therapy on the Serotonergic System and Mood in Postmenopausal Women
ClinicalTrials.gov study NCT00755963. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Figure 3 from: Nocheva H, Sabit Z, Bakalov D, Grigorov E (2021) Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception. Pharmacia 68(1): 109-115. https://doi.org/10.3897/pharmacia.68.e49219
Figure 3 Bidirectional effects of (A) DPAT, (B) AEA, and (C) AEA+DPAT in intact animals and after 1h HS.
Figure 2 from: Nocheva H, Sabit Z, Bakalov D, Grigorov E (2021) Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception. Pharmacia 68(1): 109-115. https://doi.org/10.3897/pharmacia.68.e49219
Figure 2 Effects of CB1-agonist (AEA) and 5НТ1А-agonists (DPAT) alone administration on nociceptive (PP) thresholds in (A) intact animals (int) and (B) animals subjected to 1 hour of heat stress (1h HS) without and after pretreatment with CB1- and 5НТ1А-antagonists (AM and NAN, respectively). PP-thresholds are represented as mean values ± S.E.M. in arbitrary units (AU). ***p < 0.001, **p < 0.01, *p < 0.05 vs. controls. A. +++p < 0.001, ++p < 0.01 vs. int+AEA+DPAT. int+NAN+DPAT were compared to int+DPAT – xxxp < 0.001, xxp < 0.01; int+AM+AEA were compared to int+AEA – $$$ p < 0.001. B. +++p < 0.001, ++p < 0.01 vs. 1h HS; xxxp < 0.001, xxp < 0.01 vs. 1h HS+AEA+DPAT. 1h HS+NAN+DPAT were compared to 1h HS+DPAT – $$$p < 0.001, $$p < 0.01; 1h HS+AM+AEA were compared to 1h HS+AEA – &&&p < 0.001.
Figure 1 from: Nocheva H, Sabit Z, Bakalov D, Grigorov E (2021) Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception. Pharmacia 68(1): 109-115. https://doi.org/10.3897/pharmacia.68.e49219
Figure 1 Effects of CB1- and 5НТ1А-agonists (AEA+DPAT) administration on nociceptive (PP) thresholds in (A) intact animals (int) and (B) animals subjected to 1 hour of heat stress (1 h HS) without and after pretreatment with CB1- and 5НТ1А-antagonists (AM and NAN, respectively). PP-thresholds are represented as mean values ± S.E.M. in arbitrary units (AU). ***p < 0.001, **p < 0.01 vs. controls. A. +++p < 0.001, ++p < 0.01 vs. int+AEA+DPAT. B. +++p < 0.001 vs. 1 h HS; xxxp < 0.001, xxp < 0.01 vs. 1 h HS+AEA+DPAT.
PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
ClinicalTrials.gov study NCT03581305. IPD Sharing: NO. Countries: 1. Publications: 0.
Rebalancing the Serotonergic System in Cocaine Dependence
ClinicalTrials.gov study NCT03266939. IPD Sharing: NO. Countries: 1. Publications: 0.
The Role of Central Serotonergic and Adrenergic Systems in the Effectiveness of DNIC (Diffuse Noxious Inhibitory Control
ClinicalTrials.gov study NCT00660751. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Does VNS Interact With the Serotonergic and Immune System in Children With Intractable Epilepsy?
ClinicalTrials.gov study NCT01378611. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients
ClinicalTrials.gov study NCT01352572. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Serotonergic Transmitter System in Dementia and Affective Disorders
ClinicalTrials.gov study NCT00192998. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serotonergic System and Violent Video Games
ClinicalTrials.gov study NCT01644071. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons
GEO Series GSE220744. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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