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304 results for “serotonin”
in vivo electrophysiological data of DRN serotonin neurons
<p>This repository contains in vivo electrophysiological data of DRN serotonin neurons of freely behaving mice.</p> <p>The data is related to the following research article: Li, Y., Zhong, W., Wang, D. et al. Serotonin neurons in the dorsal raphe nucleus encode reward signals. Nat Commun 7, 10503 (2016). https://doi.org/10.1038/ncomms10503 Please refer to the original publication for details.</p> <p>Please refer to the Readme.txt in the files for details.</p> <p> </p>
Neurobiology Research Unit – Serotonin Atlas
<p>A high-resolution positron emission tomography (PET)- and magnetic resonance imaging-based human brain atlas of four important serotonin receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT4) and the serotonin transporter (5-HTT) is presented. The actual dataset includes five NIfTI images (one NIfTI for each serotonin tracer) and 10 FreeSurfer surfaces with average non-displaceable binding potential (BP<sub>ND</sub>) values (two Freesurfer surfaces for each serotonin tracer). The molecular imaging maps were related to autoradiography data and an unprecedented agreement was found, supporting the validity of the methodology and results presented, and allowing translating PET binding estimates into densities. This conversion facilitates the interpretability of the maps and allows for a direct comparison across the five 5-HT targets, in vivo in the human brain. All participants included in this study were healthy male and female controls from the Cimbi database; the data analysis was restricted to include individuals aged between 18 and 45 years. A total of 232 PET scans and corresponding structural MRI scans were acquired for 210 individual participants; 189 subjects had only one scan, 20 subjects had two scans, and a single had three scans. Scans were combined and aggregated atlases for each serotonin tracer were generated.</p> <p>For more information on the original data, please go to: <a href="https://xtra.nru.dk/FS5ht-atlas/">https://xtra.nru.dk/FS5ht-atlas/</a></p>
A structural model of the human serotonin transporter in an outward-occluded state: MD simulation data
<p>The uploads contain relevant data to supplement the study https://www.biorxiv.org/content/10.1101/637009v1, where the details of the methods are described.</p> <p>charmm_energy_minimization.inp is the input file that was used to run an energy minimization on structural models</p> <p>The two archives contain relevant MD simulation data in coordinate, parameter and trajectory files:</p> <p>hSERT_Ce.tar.gz outward-open X-ray structure PDB 5I71</p> <p>hSERT_Ceo.tar.gz outward-occluded structural model</p>
Dataset related to article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin"
<p><em>The file contains raw data related to the article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin", available from </em><a href="https://doi.org/10.1016/j.neuropharm.2020.108221">https://doi.org/10.1016/j.neuropharm.2020.108221</a><em>.</em></p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p> Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and SSRIs enhance motor skill learning and plasticity. In the present study, we used heterozygous (Het) Mecp2 female and Mecp2-null male mice to investigate whether fluoxetine, a SSRI with pleiotropic effects on neuronal circuits, rescues motor coordination deficits. Repeated administration of 10 mg/kg fluoxetine fully rescued rotarod deficit in Mecp2 Het mice regardless of age, route of administration or pre-training to rotarod. The motor improvement was confirmed in the beam walking test while no effect was observed in the hanging-wire test, suggesting a preferential action of fluoxetine on motor coordination. Citalopram mimicked the effects of fluoxetine, while the inhibition of 5-HT synthesis abolished the fluoxetine-induced improvement of motor coordination. Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. No sex differences were observed in the ability of fluoxetine to desensitize 5-HT<sub>1A</sub> autoreceptors upon repeated administration. These findings indicate that fluoxetine rescues motor coordination in Mecp2 Het mice through its ability to enhance brain 5-HT and suggest that drugs enhancing 5-HT neurotransmission may have beneficial effects on motor symptoms of RTT.</p>
A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With Depression
ClinicalTrials.gov study NCT05932407. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Serotonin differentially affects morph-specific behavior in divergent populations of a horned beetle
Associations between animal weapons and corresponding aggressive behaviors are among the most characteristic features of species, yet at the same time their co-expression is itself often strongly dependent on context, such as male condition or population ecology. Yet the mechanisms that modulate associations between aggression, morphology, and biological context remain poorly understood. The biogenic amine serotonin has been shown to regulate a wide range of aggressive and morph-specific behaviors in diverse insect species. However, the extent to which serotonin may coordinate the expression of behavior with morphology across biological contexts remains unclear. In this study, we pharmacologically increased serotonin biosynthesis in males of the polyphenic beetle, Onthophagus taurus, and assessed how this manipulation affects both aggressive and non-aggressive behaviors in alternative fighter and sneaker morphs, as well as in males derived from rapidly diverging populations characterized by disparate levels of competition for mates. We find (i) that enhancing serotonin biosynthesis increases most measures of aggressive behaviors, but influences only a subset of non-aggressive behaviors, (ii) that similar serotonin-mediated behavioral changes manifest in both morphs within populations more often than just a single morph, and (iii) that males derived from populations subject to disparate levels of competition for mates have diverged in their behavioral responsiveness to serotonin up-regulation. Collectively, our study suggests that serotonin signaling plays a critical role in the regulation of male behavior and its evolution, including in the context of rapid, short term population divergence.
Data for: Serotonin transporter (SERT) polymorphisms, personality and problem-solving in urban great tits
<p class="CxSpFirst"><span><span><span><span><span><span><span><span><span><span><span>Understanding underlying genetic variation can elucidate how diversity in behavioral phenotypes evolves and is maintained. Genes in the serotonergic signaling pathway, including the serotonin transporter gene (<i>SERT)</i>, are candidates for affecting animal personality, cognition and fitness. In a model species, the great tit (<i>Parus major</i>), we reevaluated previous findings suggesting relationships between <i>SERT</i> polymorphisms, neophobia, exploratory behavior and fitness parameters, and performed a first test of the relationship between single nucleotide polymorphisms (SNPs) in SERT and problem-solving in birds. We found some evidence for associations between <i>SERT </i>SNPs and neophobia, exploratory behavior and laying date. Furthermore, several SNPs were associated with behavioral patterns and success rates during obstacle removal problem-solving tests performed at nest boxes. In females, minor allele homozygotes (AA) for nonsynonymous SNP226 in exon 1 made fewer incorrect attempts and were more likely to problem-solve. In both sexes, there was some evidence that minor allele homozygotes (CC) for SNP84 in exon 9 were more likely to problem-solve. Only one SNP-behavior relationship was statistically significant after correcting for multiple comparisons, but several were associated with substantial effect sizes. Our study provides a foundation for future research on the genetic basis of behavioral and cognitive variation in wild animal populations. </span></span></span></span></span></span></span></span></span></span></span></p>
Constitutive depletion of brain serotonin differentially affects rats' social and cognitive abilities
<p><strong>Background</strong> Central serotonin is an essential neuromodulator for mental disorders. It appears a promising transdiagnostic marker of distinct psychiatric disorders and a common modulator of some of their key behavioral symptoms. We aimed to identify the behavioral markers of serotonergic function in rats and compare them to human deficits.</p> <p><strong>Methods</strong> We applied a comprehensive profiling approach in adult male <em>Tph2<sup>−/−</sup></em> rats constitutively lacking central serotonin. Under classical and ethological testing conditions, we tested each individual’s cognitive, social and non-social abilities and characterized the group organization (i.e. social network, hierarchy). Using unsupervised machine learning, we identified the functions most dependent on central serotonin.</p> <p><strong>Results</strong> In classical procedures, <em>Tph2<sup>−/−</sup></em> rats presented an unexpected normal cognitive profile. Under the complex and experimenter-free conditions of their home-cage, the same <em>Tph2<sup>−/−</sup></em> rats presented drastic changes in their daily life. Brain serotonin depletion induced compulsive aggression and sexual behavior, hyperactive and hypervigilant stereotyped behavior, reduced self-care and body weight, and exacerbated corticosterone levels. Group-housed <em>Tph2<sup>−/−</sup></em> rats showed strong social disorganization with disrupted social networks and hierarchical structure, which may arise from communication deficits and cognitive blunting.</p> <p><strong>Conclusions</strong> Serotonin depletion induced a profile reminiscent of the symptomatology of impulse control and anxiety disorders. Serotonin was necessary for behavioral adaptation to dynamic social environments. In classical testing conditions, our animal model challenged the concept of an essential role of serotonin in decision-making, flexibility, and impulsivity, although developmental compensations may have occurred. These contrasting findings highlight the need to generalize the evaluation of animal models’ multidimensional functions within the complexity of the social living environment.</p>
A mechanism of uncompetitive inhibition of the serotonin transporter
<p>The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute carrier (SLC). During its eponymous action - i.e., the retrieval of serotonin from the extracellular space - SERT undergoes a conformational cycle. Typical inhibitors (antidepressant drugs and cocaine), partial and full substrates (amphetamines and their derivatives) and atypical inhibitors (ibogaine analogues) bind preferentially to different states in this cycle. This results in competitive or non-competitive transport inhibition. Here, we explored the action of N-formyl-1,3-bis (3,4-methylenedioxyphenyl)-prop-2-yl-amine (ECSI#6) on SERT: inhibition of serotonin uptake by ECSI#6 was enhanced with increasing serotonin concentration. Conversely, the KM for serotonin was lowered by augmenting ECSI#6. ECSI#6 bound with low affinity to the outward-facing state of SERT but with increased affinity to a potassium-bound state. Electrophysiological recordings showed that ECSI#6 preferentially interacted with the inward-facing state. Kinetic modeling recapitulated the experimental data and verified that uncompetitive inhibition arose from preferential binding of ECSI#6 to the K+-bound, inward-facing conformation of SERT. This binding mode predicted a pharmacochaperoning action of ECSI#6, which was confirmed by examining its effect on the folding-deficient mutant SERT-PG601,602AA: pre-incubation of HEK293 cells with ECSI#6 restored export of SERT-PG601,602AA from the endoplasmic reticulum and substrate transport. Similarly, in transgenic flies, administration of ECSI#6 promoted delivery of SERT-PG601,602AA to the presynaptic specialization of serotonergic neurons. To the best of our knowledge, ECSI#6 is the first example of an uncompetitive SLC inhibitor. Pharmacochaperones endowed with the binding mode of ECSI#6 are attractive because they can rescue misfolded transporters at concentrations, which cause modest transport inhibition.</p>
Supplementary material: High and hyper: is serotonin to blame for fentanyl-induced psychomotor side-effects in pigs?
<p>Supplementary material for article paper High and hyper: is serotonin to blame for fentanyl-induced psychomotor side-effects in pigs? </p>
Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging
ClinicalTrials.gov study NCT02473250. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression
ClinicalTrials.gov study NCT00093847. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Switching From Generic Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) to Three Different Dose Initiation Strategies With Vilazod
ClinicalTrials.gov study NCT02015546. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Fasting and Calorie-Restricted Diets on Dopamine and Serotonin Levels Among Obese Women With BED and FA
ClinicalTrials.gov study NCT04873648. IPD Sharing: NO. Countries: 1. Publications: 11.
Study to Evaluate the Effect of AFQ056 in Obsessive Compulsive Disorder (OCD) Patients Resistant to Selective Serotonin Reuptake Inhibitor (SSRI) Therapy
ClinicalTrials.gov study NCT01813019. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Study of 6(S)-5-MTHF Among Selective Serotonin Reuptake Inhibitor-Resistant Outpatients With Major Depressive Disorder
ClinicalTrials.gov study NCT00955955. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
ClinicalTrials.gov study NCT05470465. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Clinical Neurobiology of Serotonin and Addiction
ClinicalTrials.gov study NCT00732901. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Estrogen and Serotonin on Changing Brain Chemistry
ClinicalTrials.gov study NCT01208324. IPD Sharing: NO. Countries: 1. Publications: 5.
Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease Outcomes
ClinicalTrials.gov study NCT04218123. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.