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38 results for “serotonin transporter”
A structural model of the human serotonin transporter in an outward-occluded state: MD simulation data
<p>The uploads contain relevant data to supplement the study https://www.biorxiv.org/content/10.1101/637009v1, where the details of the methods are described.</p> <p>charmm_energy_minimization.inp is the input file that was used to run an energy minimization on structural models</p> <p>The two archives contain relevant MD simulation data in coordinate, parameter and trajectory files:</p> <p>hSERT_Ce.tar.gz outward-open X-ray structure PDB 5I71</p> <p>hSERT_Ceo.tar.gz outward-occluded structural model</p>
Data for: Serotonin transporter (SERT) polymorphisms, personality and problem-solving in urban great tits
<p class="CxSpFirst"><span><span><span><span><span><span><span><span><span><span><span>Understanding underlying genetic variation can elucidate how diversity in behavioral phenotypes evolves and is maintained. Genes in the serotonergic signaling pathway, including the serotonin transporter gene (<i>SERT)</i>, are candidates for affecting animal personality, cognition and fitness. In a model species, the great tit (<i>Parus major</i>), we reevaluated previous findings suggesting relationships between <i>SERT</i> polymorphisms, neophobia, exploratory behavior and fitness parameters, and performed a first test of the relationship between single nucleotide polymorphisms (SNPs) in SERT and problem-solving in birds. We found some evidence for associations between <i>SERT </i>SNPs and neophobia, exploratory behavior and laying date. Furthermore, several SNPs were associated with behavioral patterns and success rates during obstacle removal problem-solving tests performed at nest boxes. In females, minor allele homozygotes (AA) for nonsynonymous SNP226 in exon 1 made fewer incorrect attempts and were more likely to problem-solve. In both sexes, there was some evidence that minor allele homozygotes (CC) for SNP84 in exon 9 were more likely to problem-solve. Only one SNP-behavior relationship was statistically significant after correcting for multiple comparisons, but several were associated with substantial effect sizes. Our study provides a foundation for future research on the genetic basis of behavioral and cognitive variation in wild animal populations. </span></span></span></span></span></span></span></span></span></span></span></p>
A mechanism of uncompetitive inhibition of the serotonin transporter
<p>The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute carrier (SLC). During its eponymous action - i.e., the retrieval of serotonin from the extracellular space - SERT undergoes a conformational cycle. Typical inhibitors (antidepressant drugs and cocaine), partial and full substrates (amphetamines and their derivatives) and atypical inhibitors (ibogaine analogues) bind preferentially to different states in this cycle. This results in competitive or non-competitive transport inhibition. Here, we explored the action of N-formyl-1,3-bis (3,4-methylenedioxyphenyl)-prop-2-yl-amine (ECSI#6) on SERT: inhibition of serotonin uptake by ECSI#6 was enhanced with increasing serotonin concentration. Conversely, the KM for serotonin was lowered by augmenting ECSI#6. ECSI#6 bound with low affinity to the outward-facing state of SERT but with increased affinity to a potassium-bound state. Electrophysiological recordings showed that ECSI#6 preferentially interacted with the inward-facing state. Kinetic modeling recapitulated the experimental data and verified that uncompetitive inhibition arose from preferential binding of ECSI#6 to the K+-bound, inward-facing conformation of SERT. This binding mode predicted a pharmacochaperoning action of ECSI#6, which was confirmed by examining its effect on the folding-deficient mutant SERT-PG601,602AA: pre-incubation of HEK293 cells with ECSI#6 restored export of SERT-PG601,602AA from the endoplasmic reticulum and substrate transport. Similarly, in transgenic flies, administration of ECSI#6 promoted delivery of SERT-PG601,602AA to the presynaptic specialization of serotonergic neurons. To the best of our knowledge, ECSI#6 is the first example of an uncompetitive SLC inhibitor. Pharmacochaperones endowed with the binding mode of ECSI#6 are attractive because they can rescue misfolded transporters at concentrations, which cause modest transport inhibition.</p>
Data for: Serotonin transporter (SERT) polymorphisms, personality and problem-solving in urban great tits
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A mechanism of uncompetitive inhibition of the serotonin transporter
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Structural Rearrangement of the Serotonin Transporter Intracellular Gate Induced by Thr276 Phosphorylation
<p>Molecular dynamics trajectories for <em>Structural Rearrangement of the Serotonin Transporter Intracellular Gate Induced by Thr276 Phosphorylation</em> by Matthew C. Chan, Erik Procko, Diwakar Shukla.</p> <p> </p> <p> </p>
Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter
ClinicalTrials.gov study NCT02717052. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Sex Steroids and the Serotonin Transporter
ClinicalTrials.gov study NCT01065220. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)
ClinicalTrials.gov study NCT01074515. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Adaptive developmental plasticity in rhesus macaques: the serotonin transporter gene interacts with maternal care to affect juvenile social behaviour
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Data from: Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture
Cumulative culture ostensibly arises from a set of sociocognitive processes which includes high-fidelity production imitation, prosociality and group identification. The latter processes are facilitated by unconscious imitation or social mimicry. The proximate mechanisms of individual variation in imitation may thus shed light on the evolutionary history of the human capacity for cumulative culture. In humans, a genetic component to variation in the propensity for imitation is likely. A functional length polymorphism in the serotonin transporter gene, the short allele at 5HTTLPR, is associated with heightened responsiveness to the social environment as well as anatomical and activational differences in the brain's imitation circuity. Here, we evaluate whether this polymorphism contributes to variation in production imitation and social mimicry. Toddlers with the short allele at 5HTTLPR exhibit increased social mimicry and increased fidelity of demonstrated novel object manipulations. Thus, the short allele is associated with two forms of imitation that may underlie the human capacity for cumulative culture. The short allele spread relatively recently, possibly due to selection, and its frequency varies dramatically on a global scale. Diverse observations can be unified via conceptualization of 5HTTLPR as influencing the propensity to experience others' emotions, actions and sensations, potentially through the mirror mechanism.
Serotonin Transporters in Alcoholism
ClinicalTrials.gov study NCT00085865. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Serotonin Transporters in Obsessive-Compulsive-Related Disorders
ClinicalTrials.gov study NCT00082550. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Brain Imaging of Serotonin Transporters in the Brain
ClinicalTrials.gov study NCT00059046. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture
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Transcriptional changes in specifc subsets of Drosophila neurons following inhibition of the serotonin transporter
GEO Series GSE227935. Drosophila melanogaster. 13 samples. Type: Expression profiling by high throughput sequencing.
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [RNA-seq]
GEO Series GSE246539. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing.
Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls
ClinicalTrials.gov study NCT01160263. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Serotonin Transporter Availability for Prognosing Major Depressive Disorder (MDD) Treatment and Detecting MDD
ClinicalTrials.gov study NCT02473783. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Phase 1, Open-Label, Single-photon Emission Computed Tomography (SPECT) Study to Evaluate Serotonin and Dopamine Transporter Occupancy After Multiple Dose Administration of SEP-228432 to Achieve Ste
ClinicalTrials.gov study NCT01531972. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.