Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
34
datasets available to search
ShareScore release 0.9.0
Dataset results
34 results for “serum amyloid A”
Depletion of Serum Amyloid P Component to Enhance the Immune Response to DNA Vaccination
ClinicalTrials.gov study NCT02425241. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Serum amyloid A protein concentration in blood is influenced by genetic differences in the cheetah (Acinonyx jubatus)
Systemic amyloid A (AA) amyloidosis is a major cause of morbidity and mortality among captive cheetahs. The self-aggregating AA protein responsible for this disease is a byproduct of serum amyloid A (SAA) protein degradation. Transcriptional induction of the SAA1 gene is dependent on both C/EBPβ and NF-κB cis-acting elements within the promoter region. In cheetahs, 2 alleles exist for a single guanine nucleotide deletion in the putative NF-κB binding site. In this study, a novel genotyping assay was developed to screen for the alleles. The results show that the SAA1A −97delG allele is associated with decreased SAA protein concentrations in the serum of captive cheetahs (n = 58), suggesting genetic differences at this locus may be affecting AA amyloidosis prevalence. However, there was no significant difference in the frequency of the SAA1A −97delG allele between individuals confirmed AA amyloidosis positive versus AA amyloidosis negative at the time of necropsy (n = 48). Thus, even though there is evidence that having more copies of the SAA1A −97delG allele results in a potentially protective decrease in serum concentrations of SAA protein in captive cheetahs, genotype is not associated with this disease within the North American population. These results suggest that other factors are playing a more significant role in the pathogenesis of AA amyloidosis among captive cheetahs.
Data from: Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced transcripts in digestive tissues following microbiota colonization. Saa is a conserved secreted protein produced in the intestine and liver with described effects on neutrophils in vitro, however its in vivo functions remain poorly defined. We engineered saa mutant zebrafish to test requirements for Saa on innate immunity in vivo. Zebrafish mutant for saa displayed impaired neutrophil responses to wounding but augmented clearance of pathogenic bacteria. At baseline, saa mutants exhibited moderate neutrophilia and altered neutrophil tissue distribution. Molecular and functional analyses of isolated neutrophils revealed that Saa suppresses expression of pro-inflammatory markers and bactericidal activity. Saa's effects on neutrophils depend on microbiota colonization, suggesting this protein mediates the microbiota's effects on host innate immunity. To test tissue-specific roles of Saa on neutrophil function, we over-expressed saa in the intestine or liver and found that sufficient to partially complement neutrophil phenotypes observed in saa mutants. These results indicate Saa produced by the intestine in response to microbiota serves as a systemic signal to neutrophils to restrict aberrant activation, decreasing inflammatory tone and bacterial killing potential while simultaneously enhancing their ability to migrate to wounds.
Data from: Serum amyloid A protein concentration in blood is influenced by genetic differences in the cheetah (Acinonyx jubatus)
Open the record for dataset details and reuse information.
Data from: Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
Open the record for dataset details and reuse information.
Serum amyloid and serum amyloid P are not induced in response to diesel exhaust particles or carbon black
GEO Series GSE11346. Mus musculus. 23 samples. Type: Expression profiling by array.
Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition
GEO Series GSE291559. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Liver]
GEO Series GSE232264. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Serum Amyloid A proteins reduce bone mass during mycobacterial infections
GEO Series GSE215856. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Serum Amyloid A (SAA) Transcriptomics Sequencing on enteroid
GEO Series GSE306974. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses II [RNA-Seq]
GEO Series GSE71281. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Serum Amyloid A (SAA) induces transcription affecting inflammation
GEO Series GSE306801. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins
GEO Series GSE232701. Mus musculus. 44 samples. Type: Expression profiling by high throughput sequencing.
An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses [RIP-Seq]
GEO Series GSE70598. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [HotvsCold]
GEO Series GSE232260. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins [Tumor]
GEO Series GSE232266. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Maternal Serum Amyloid A Levels in Pregnancies Complicated With Preterm Labour.
ClinicalTrials.gov study NCT03205020. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serum Amyloid A in Women With Unexplained Infertility
ClinicalTrials.gov study NCT03918200. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
GDM Patients and Serum Amyloid A and Interleukin-1 (IL-1) Receptor Antagonist
ClinicalTrials.gov study NCT04238936. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Predictive Markers of the Course of Covid-19 Based on Biomarker Serum Amyloid A (SAA) and Genetic Markers
ClinicalTrials.gov study NCT07120269. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.