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37 results for “sex steroids”
Summary statistics from "Sex-Specific Causal Relations between Steroid Hormones and Obesity—A Mendelian Randomization Study"
<p>GWAMA summary statistics of four steroid hormone levels and one steroid hormone ratio using fixed-effect model.</p> <p>When using this data, please cite: Pott J, Horn K, Zeidler R, et al.. Sex-Specific Causal Relations between Steroid Hormones and Obesity - A Mendelian Randomization Study. <em>Metabolites</em> <strong>2021</strong>, <em>11</em>, 738. https://doi.org/10.3390/metabo11110738</p> <p>All txt files contain the following columns:</p> <ul> <li>markername</li> <li>chr</li> <li>bp_hg19 (base position according to hg19)</li> <li>ea (effect allele)</li> <li>oa (other allele)</li> <li>eaf (effect allele frequency)</li> <li>info (minimal info score across all used studies)</li> <li>nSamples (sample size per SNP)</li> <li>nStudies (number of studies)</li> <li>beta (effect estimate)</li> <li>se (standard error)</li> <li>p (p-value)</li> <li>I2 (SNP heterogeneity across studies)</li> <li>phenotype (phenotyp setting)</li> </ul>
Sperm quality parameters and sex steroid concentrations in male and female meagre (Argyrosomus regius) held under constant or cycling temperatures
<p>The dataset contains excel files with sperm quality parameters measured with Computer Assisted Sperm Analysis (CASA), plasma sex steroids (testosterone, 11-ketotestosterone, estradiol and 17a,20β-dihydroxy-4-pregnen-3-one) measured with enzyme-linked immunosorbent assays (ELISAs), oocyte diameters and egg fecundity and % fertilisation data in the meagre <em>Argyrosomus regius</em> held under either attenuated seasonal water temperature (16.4 to 19.6ºC) or relatively constant water temperature (19.4 ± 0.6ºC).</p>
Age, sex, length (mm), weight (g), and plasma sex steroid concentrations (ng/ml) of greater amberjack Seriola dumerili reared in sea cages during the process of sex differentiation
<p>The dataset contains an excel file with the age, sex, total length (mm), wet weight (g) and plasma concentrations (ng/ml) of the following sex steroids, measured with the use of liquid chromatography/tandem mass spectrometry (LC-MS/MS): adrenosterone (Ad), androstenedione (Δ4), 11-ketotestosterone (11ΚΤ), testosterone (Τ), estradiol (Ε2), progesterone (P4) and 17,20β-dihydroxy-4-pregnen-3-one (17,20βP).</p>
Figure 4 in Differential gene expression pattern and plasma sex steroids during testicular development in Genyatremus luteus (Perciforme: Haemulidae) (Bloch, 1790)
Figure 4. Principal component analysis (PCA) used to classify the influence of lhr and er gene expression, plasma steroids (11-KT, 17- OHP and E2), ichthyological parameters and GSI on male G. luteus individuals. Legend: LHR = LH receptor; ER = estrogen receptor; KT = 11-ketotestosterone; E2 = 17β-estradiol; OHP = 17-α-hydroxyprogesterone; TW = total weight; TL = total length; GW = gonad weight; GSI = gonadosomatic index.
Figure 1 in Differential gene expression pattern and plasma sex steroids during testicular development in Genyatremus luteus (Perciforme: Haemulidae) (Bloch, 1790)
Figure 1. Photomicrographs of germ cell and testes development stages of Genyatremus luteus. Stages were determined as (A) Immature, (B) Maturing, (C) Mature. Abbreviations are as follows: SPG, spermatogonia; SPC, spermatocyte; SPZ, spermatozoa. All panels were at 60x magnification.
Figure 2 in Differential gene expression pattern and plasma sex steroids during testicular development in Genyatremus luteus (Perciforme: Haemulidae) (Bloch, 1790)
Figure 2. Steroid concentrations in the blood plasma of male Genyatremus luteus individuals during their reproductive cycle. (A) 11-ketotestosterone. (B) 17 α-hidroxy progesterone. (C) 17β-estradiol. Data are represented as mean ± SEM. abc: indicates statistically significant difference (p<0.05).
Data from: Levels of sex steroids in plethodontid salamanders: A comparative study within the genus Aneides
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Sex Steroids, Sleep, and Metabolic Dysfunction in Women
ClinicalTrials.gov study NCT00805207. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data and code from: How a territorial challenge changes sex steroid-related gene networks in the female brain: A field experiment with the tree swallow
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Data from: Polybrominated diphenyl ether (DE-71) exposure skews phenotypic sex ratio, and alters steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis
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Data from: Feather steroid hormone concentrations in relation to age, sex, and moulting time in a long distance migratory passerine
In birds, concentrations of testosterone (T) and corticosterone (Cort) are closely connected with many morphological, behavioural and other physiological traits, including reproduction, metabolism, immunity, and fitness. The direction of the effect of these hormones on above-mentioned traits, and the potential feedback between hormones are in general unclear; in addition, knowledge on how age and sex can affect T and Cort concentrations is still inconsistent. Our study used a novel method to analyse testosterone and corticosterone in feathers (Tf, Cortf) based on the pre-column chemical derivatization of hormones before LC-MS/MS analysis. Unlike previously used methods (RIA, EIA), our analytical procedure allows simultaneous analysis of both hormones from small amounts of feathers (4-25 mg) and thus overcomes the problem of insufficient detection limits. We applied this method to reveal associations between Tf and Cortf hormone concentrations and feather growth, age, and sex in feathers grown during the post-breeding (flanks) and pre-breeding (tails) periods in barn swallows (Hirundo rustica). There was neither a correlation between pre-breeding and post-breeding Tf, nor between pre-breeding and post-breeding Cortf. Tail Cortf concentrations were negatively associated with tail feather growth rates. Feather hormone concentrations were correlated in the pre-breeding period, negatively in males but positively in females. Both Cortf and Tf were higher in young birds compared to older ones, indicating either an age-related decrease in hormone concentrations within individuals, or the selective disappearance of individuals with high steroid concentrations. Males and females did not differ in Cortf, but Tf concentrations were higher in males than females, particularly during the pre-breeding period. In this study, we provide an effective method for analysing hormones in feathers in an ecological context, especially in situations when the total amount of feathers available for the analysis is limited.
Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression
ClinicalTrials.gov study NCT02661789. IPD Sharing: YES. Countries: 1. Publications: 2.
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health
ClinicalTrials.gov study NCT03795688. IPD Sharing: YES. Countries: 1. Publications: 11.
Association of Tumour Grade and Sex Steroid Receptor as a Prognostic Index in Breast Cancer
ClinicalTrials.gov study NCT04707287. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Effects of Sex Steroids on the Serotonin System
ClinicalTrials.gov study NCT02715232. IPD Sharing: YES. Countries: 1. Publications: 8.
Sex Steroids and the Serotonin Transporter
ClinicalTrials.gov study NCT01065220. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failure
ClinicalTrials.gov study NCT00732693. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue
ClinicalTrials.gov study NCT00543166. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Feather steroid hormone concentrations in relation to age, sex, and moulting time in a long distance migratory passerine
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Data from: Regional difference in sex steroid action on formation of morphological sex differences in the anteroventral periventricular nucleus and principal nucleus of the bed nucleus of the stria terminalis
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understood. We previously reported that masculinization of the principal nucleus of the bed nucleus of the stria terminalis (BNSTp), which is larger and has more neurons in males than in females, involves aromatized testosterone that acts via estrogen receptor-α (ERα), but not estrogen receptor-β (ERβ). Here, we examined sex steroid action on the formation of the anteroventral periventricular nucleus (AVPV) that is larger and has more neurons in females. Morphometrical analysis of transgenic mice lacking aromatase, ERα, or ERβ genes revealed that the volume and neuron number of the male AVPV were significantly increased by deletion of aromatase and ERα genes, but not the ERβ gene. We further examined the AVPV and BNSTp of androgen receptor knockout (ARKO) mice. The volume and neuron number of the male BNSTp were smaller in ARKO mice than those in wild-type mice, while no significant effect of ARKO was found on the AVPV and female BNSTp. We also examined aromatase, ERα, and AR mRNA levels in the AVPV and BNSTp of wild-type and ARKO mice on embryonic day (ED) 18 and postnatal day (PD) 4. AR mRNA in the BNSTp and AVPV of wild-type mice was not expressed on ED18 and emerged on PD4. In the AVPV, the aromatase mRNA level was higher on ED18, although the ERα mRNA level was higher on PD4 without any effect of AR gene deletion. Aromatase and ERα mRNA levels in the male BNSTp were significantly increased on PD4 by AR gene deletion. These results suggest that estradiol signaling via ERα during the perinatal period and testosterone signaling via AR during the postnatal period are required for masculinization of the BNSTp, whereas the former is sufficient to defeminize the AVPV.
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