Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
78
datasets available to search
ShareScore release 0.9.0
Dataset results
78 results for “short stature”
Genetic architecture associated with familial short stature
<p><strong>Context</strong></p> <p>Human height is an inheritable, polygenic trait under complex and multi-locus genetic regulation. Familial short stature (FSS; also called genetic short stature) is the most common type of short stature and is insufficiently known.</p> <p><strong>Objective</strong></p> <p>To investigate the FSS genetic profile and develop a polygenic risk predisposition score for FSS risk prediction.</p> <p><strong>Design and Setting</strong></p> <p>The FSS case group of Han Chinese ancestry was diagnosed by pediatric endocrinologists in Taiwan.</p> <p><strong>Patients and Interventions</strong></p> <p>The genetic profile of 1,163 FSS cases was identified by using a bootstrapping sub-sampling and genome-wide association studies (GWAS) method.</p> <p><strong>Main Outcome Measures</strong></p> <p>Genetic profile, polygenic risk predisposition score for risk prediction.</p> <p><strong>Results</strong></p> <p>Ten novel genetic SNPs and 9 reported GWAS human height-related SNPs were identified for FSS risk. These 10 novel SNPs served as a polygenic risk predisposition score for FSS risk prediction (area under curve (AUC): 0.940 in the testing group). This FSS polygenic risk predisposition score was also associated with the height reduction regression tendency in the general population.</p> <p><strong>Conclusion</strong></p> <p>A polygenic risk predisposition score composed of 10 genetic SNPs is useful for FSS risk prediction and the height reduction tendency. Thus, it might contribute to FSS risk in the Han Chinese population from Taiwan.</p>
Data from: forest stand dynamics of a short-stature tree species: ecological knowledge for sustainable forest management
<p>This data set is a forest inventory of <em>Nothofagus antarctica</em> in southern Chile. More than 20 sites were selected. In each site, parallel transects were set and every 30 m a sampling point was set where the distance to the nearest four trees (in accordance with the cardinal points) were measured.</p>
Additional data for Insights for the Partitioning of Ecosystem Evaporation and Transpiration in Short-Statured Croplands
<p>Data includes LAI and SPA-Crop model outputs for the 2018-2019 winter wheat and for the 2019-2020 winter barley crop seasons.<br> Eddy covariance and meteorological data from Oensingen (CH-Oe2) are available at http://www.europe-fluxdata.eu/home/site-details?id=CH-Oe2</p>
Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature
ClinicalTrials.gov study NCT01248416. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Phase 3 Study to Evaluate the Safety and Efficacy of Saizen® in Children With Idiopathic Short Stature (ISS)
ClinicalTrials.gov study NCT01746862. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment With Recombinant Human Growth Hormone (GH) in Children With Short Stature Secondary to a Long Term Corticoid Therapy
ClinicalTrials.gov study NCT00174187. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years
ClinicalTrials.gov study NCT01066052. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating the Long-term Efficacy and Safety of Two Doses of NN-220 (Somatropin) in Short Stature Due to Noonan Syndrome
ClinicalTrials.gov study NCT01927861. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy and Safety of Recombinant Human Growth Hormone on Height Velocity in Subjects With Idiopathic Short Stature
ClinicalTrials.gov study NCT01778023. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: forest stand dynamics of a short-stature tree species: ecological knowledge for sustainable forest management
Open the record for dataset details and reuse information.
Genetic architecture associated with familial short stature
Open the record for dataset details and reuse information.
DNA methylation profiling and genomic analysis in 20 children with short stature who were born small-for-gestational age
<p><b><span>Purpose:</span></b> In a significant proportion of children born small-for-gestational age (SGA) with failure of catch-up growth, the etiology of short stature remains unclear after routine diagnostic work-up. We wanted to investigate if extensive analysis of the (epi)genome can unravel the cause of growth failure in a significant portion of these children.</p> <p><b><span>Patients and Methods:</span></b><span> Twenty </span><span>SGA</span><span> children treated with growth hormone (GH) because of short stature were selected from the BELGROW database of the Belgian Society for Pediatric Endocrinology and Diabetology </span>for<span> exome sequencing, SNP array and genome-wide methylation analysis to identify the (epi)genetic cause. First year response to GH was compared to the response of SGA patients in the KIGS database.</span></p> <p><b><span>Results:</span></b><span> We identified (likely) pathogenic variants in 4 children (from 3 families) using exome sequencing and found pathogenic CNV in 2 probands using SNP array. In a child harboring a <i>NSD1</i>-containing microduplication, we identified a DNA methylation signature that is opposite to the genome-wide DNA methylation signature of Sotos syndrome. Moreover, we observed multi-locus imprinting disturbances in two children in whom no other genomic alteration could be identified. Five out of 6 children with a genetic diagnosis had an "above average" response to GH.</span></p> <p><b><span>Conclusions: </span></b><span>The study indicates that a more advanced approach with deep genotyping can unravel unexpected (epi)genomic alterations in SGA children with persistent growth failure. Most SGA children with a genetic diagnosis had a good response to GH treatment.</span></p>
Causal effect of familial short stature on three quantitative traits in Taiwan
<p><span><strong>Objectives</strong>: </span><span>With the accumulation of genetic basis for </span><span>familial (genetic) short stature (FSS)</span><span>, the genetic association of FSS with health-related outcomes remains to be elucidated. In this study, we aimed to investigate the FSS genetic architecture and its causal effect on three quantitative traits in Taiwan. </span></p> <p><span><strong>Methods</strong>:</span><span> We </span><span>conducted an FSS genome-wide association study (GWAS) analysis (1,640 FSS cases and 22,372 controls). We performed a GWAS meta-analysis for the Taiwanese meta-height from the Taiwan Biobank (</span><span>TWB)_height (N = 67,452) and the China Medical University Hospital (CMUH)_height GWAS summary statistics (N = 88,854). </span><span>We calculated three polygenic risk scores (PRSs) of SNPs (<em>P</em> < 5 x 10<sup>-8</sup>) for FSS and Taiwanese meta-height with/without FSS, respectively. We explored the associations between three PRSs and the measured height, respectively. We also performed </span><span>Mendelian randomization (MR) analysis</span><span> for the causal effect of FSS and Taiwanese meta-height with/without FSS, on anthropometric, bone mineral density (BMD), and female reproductive traits</span><span>. </span></p> <p><span><strong>Results</strong>: </span><span>FSS GWAS identified 172 SNPs in 4 genomic regions, reported in height </span><span>(<em>P</em> < 5 x 10<sup>-8</sup>)</span><span>. Higher FSS genetic scores correlate with an increased risk of short stature and height reduction tendency </span><span>(</span><em><span>p</span></em> <span><</span><span> 0.001).</span><span> The causal effect showed that a higher risk of FSS was associated with decreased body height, but increased body mass index, and body fat</span> <span>(</span><em><span>p</span></em> <span><</span><span> 0.001)</span><span>. However, higher genetic scores of Taiwanese meta-height with/without FSS correspond with increased body height, body weight, hip circumference, and age at menarche, but decreased BMD_T-score, BMD_Z-score, and stiffness index </span><span>(</span><em><span>p</span></em> <span><</span><span> 0.001)</span><span>. </span></p> <p><span><strong>Conclusion</strong>: </span><span>This study </span><span>contributes to the FSS and height genetic features and their causal effects on three quantitative traits </span><span>in individuals of Han Chinese ancestry in Taiwan. </span></p>
Fitness Level in Short Stature Children and After Growth Hormone Treatment
ClinicalTrials.gov study NCT02977091. IPD Sharing: NO. Countries: 1. Publications: 3.
A Natural History Study in Children With a Type II Collagen Disorder With Short Stature
ClinicalTrials.gov study NCT05408715. IPD Sharing: UNDECIDED. Countries: 2. Publications: 4.
Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat SGA Children With Short Stature
ClinicalTrials.gov study NCT02375620. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vosoritide for Selected Genetic Causes of Short Stature
ClinicalTrials.gov study NCT04219007. IPD Sharing: NO. Countries: 1. Publications: 1.
Short Stature Related Distress
ClinicalTrials.gov study NCT01246219. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Height Versus Height and Weight Based Spinal Bupivacaine on Maternal Haemodynamics for Elective Cesarean in Short Stature Patients
ClinicalTrials.gov study NCT04082676. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature
ClinicalTrials.gov study NCT00001190. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.