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Dataset results
35 results for “speech disorder”
Effectiveness of Ultrasound-Aided Articulation Therapy for Children with Speech Sound Disorders
ClinicalTrials.gov study NCT06831396. IPD Sharing: Not stated. Countries: 1. Publications: 42.
Application of Ideal Binary Masking to Disordered Speech
ClinicalTrials.gov study NCT05244603. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation
<p><b><span>Objective:</span></b><span> Determining the genetic basis of speech disorders provides insight into the neurobiology of human communication. Despite intensive investigation over the past two decades, the etiology of most children with speech disorder remains unexplained. Here we </span>searched for a genetic etiology in children with severe speech disorder, specifically childhood apraxia of speech (CAS).</p> <p><b>Methods:</b> Precise phenotyping together with research genome or exome analysis were performed on children referred with a primary diagnosis of CAS, as well as other medical or neurodevelopmental co-morbidities. Gene co-expression and gene set enrichment analyses analyses were conducted on high confidence gene candidates.</p> <p><b>Results:</b> 34 probands ascertained for CAS were studied. In 11/34 (32%) probands, we identified highly plausible pathogenic single nucleotide (n=10, <i>CDK13, EBF3, GNAO1, GNB1, DDX3X, MEIS2, POGZ, SETBP1, UPF2, ZNF142</i>) or copy number (n = 1, 5q14.3q21.1 locus) variants in novel genes or loci for CAS. Testing of parental DNA was available for nine probands and confirmed that the variants had arisen <i>de novo</i>. Eight genes encode proteins critical for regulation of gene transcription, and analyses of transcriptomic data found CAS-implicated genes were highly co-expressed in the developing human brain.</p> <p><b>Conclusion:</b><i> </i>We identify the likely genetic aetiology in 11 patients with CAS and implicate 9 genes for the first time. We find that CAS is often a sporadic monogenic disorder, and highly genetically heterogeneous. Highly penetrant variants implicate shared pathways in broad transcriptional regulation, highlighting the key role of transcriptional regulation in normal speech development. CAS is a distinctive, socially debilitating clinical disorder, and understanding its molecular basis is the first step towards identifying precision medicine approaches.</p>
Testing a Novel Speech Intervention in Minimally Verbal Children With Autism Spectrum Disorder (ASD)
ClinicalTrials.gov study NCT03015272. IPD Sharing: YES. Countries: 1. Publications: 6.
Intensive Speech Motor Chaining Treatment for Residual Speech Sound Disorders
ClinicalTrials.gov study NCT05929859. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Influence - Intervention Break - Children - Speech Sound Disorders
ClinicalTrials.gov study NCT03972891. IPD Sharing: NO. Countries: 1. Publications: 5.
Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders
ClinicalTrials.gov study NCT04689282. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders
ClinicalTrials.gov study NCT04939818. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Improving Perception of Speech in Noise in Children With Communication Disorders
ClinicalTrials.gov study NCT04473729. IPD Sharing: NO. Countries: 1. Publications: 3.
Task of Acoustic-phonetic Decoding on Anatomic Deficits in Paramedical Assessment of Speech Disorders for Patients Treated for Oral or Oropharyngeal Cancer
ClinicalTrials.gov study NCT04742998. IPD Sharing: NO. Countries: 1. Publications: 3.
Table to Tablet (T2T): A Novel Intervention Framework for Children With Speech Sound Disorders
ClinicalTrials.gov study NCT02490826. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Preventing Speech and Language Disorders in Children With Classic Galactosemia
ClinicalTrials.gov study NCT03838016. IPD Sharing: YES. Countries: 1. Publications: 31.
Data from: Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation
Open the record for dataset details and reuse information.
Influence of Medical Clowning in Videofluoroscopic Examination of Pediatric Speech Disorder
ClinicalTrials.gov study NCT02701322. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Characteristics of Idiopathic Familial Speech Disorders
ClinicalTrials.gov study NCT00001551. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Multimodal Analysis of Structural Voice Disorders Based on Speech and Stroboscopic Laryngoscope Video
ClinicalTrials.gov study NCT05348031. IPD Sharing: UNDECIDED. Countries: 0. Publications: 9.
tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
ClinicalTrials.gov study NCT04883229. IPD Sharing: NO. Countries: 0. Publications: 5.
Neural Indices of Intervention Outcomes in Children With Speech Sound Disorders
ClinicalTrials.gov study NCT03623100. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Characterization and Quantification of Motor Speech Disorders in Huntington's Disease: Identification of Acoustic Markers
ClinicalTrials.gov study NCT04630574. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.
ClinicalTrials.gov study NCT05670496. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.