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31
datasets available to search
ShareScore release 0.9.0
Dataset results
31 results for “subcutaneous infection”
Study of PRO 140 by Subcutaneous Administration in Adult Subjects With HIV -1 Infection
ClinicalTrials.gov study NCT00642707. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate Safety, Pharmacokinetics, and Antiviral Activity of Lenacapavir Administered Subcutaneously in Human Immunodeficiency Virus (HIV) -1 Infected Adults
ClinicalTrials.gov study NCT03739866. IPD Sharing: NO. Countries: 1. Publications: 1.
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
<p>In the skin, <em>Trypanosoma brucei </em>colonises the subcutaneous white adipose tissue (WAT) and harbours a pool of parasites competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is likely to drive adipose tissue wasting and weight loss observed in cattle and humans infected with <em>T. brucei</em>. However, mechanistically, this process is not fully understood. Here, using several complementary approaches including mass cytometry by time of flight, bulk and single cell transcriptomics, we found that <em>T. brucei</em> infection drives a local expansion of several IL-17A-producing cells in the murine WAT, including T<sub>H</sub>17 and Vg6<sup>+</sup> T cells. We also found that global IL-17 deficiency, or mice lacking IL-17 receptor expression specifically on adipocytes, were protected from infection-induced WAT wasting and weight loss. Unexpectedly, we found that abrogation of IL-17 signalling on adipocytes results in higher burden of extravascular parasites in the WAT. Taken together, our study highlights the central role of IL-17 signalling on adipocytes in controlling WAT responses to infection, suggesting that adipocytes are a critical coordinator of the tissue immune response to <em>T. brucei</em> infection. </p>
A Phase II Study of Low-Dose Interleukin-2 by Subcutaneous Injection in Combination With Antiretroviral Therapy Versus Antiretroviral Therapy Alone in Patients With HIV-1 Infection and at Least 3 Mont
ClinicalTrials.gov study NCT00000820. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Administration of Subcutaneous Teicoplanin in the Treatment of Osteoarticular Infections: Tolerance Study
ClinicalTrials.gov study NCT01815541. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) C
ClinicalTrials.gov study NCT00000870. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections
ClinicalTrials.gov study NCT03403608. IPD Sharing: NO. Countries: 1. Publications: 1.
Subcutaneously Administered Aldesleukin ( Interleukin-2; IL-2 ) Therapy in HIV-Infected Patients
ClinicalTrials.gov study NCT00000821. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Subcutaneous Sarilumab in Hospitalised Patients With Moderate-severe COVID-19 Infection (SARCOVID)
ClinicalTrials.gov study NCT04357808. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Subcutaneously Administered Interleukin-2 Therapy in HIV-Infected Patients
ClinicalTrials.gov study NCT00001357. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
ClinicalTrials.gov study NCT00001763. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
ClinicalTrials.gov study NCT01238276. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Investigation of Continuous Versus Interrupted Subcutaneous Fat Closure in Reducing Surgical Site Infection
ClinicalTrials.gov study NCT05856968. IPD Sharing: Not stated. Countries: 0. Publications: 3.
IL-17 signalling is critical for controlling subcutaneous adipose tissue wasting and parasite burden during chronic Trypanosoma brucei infection [single-cell RNA-seq]
GEO Series GSE233312. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
IL-17 signalling is critical for controlling subcutaneous adipose tissue wasting and parasite burden during chronic Trypanosoma brucei infection
GEO Series GSE233314. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Study for Evaluation of the Safety, Pharmacokinetics, and Antiviral Activity of UB-421 Subcutaneous Formulation Administered in HIV-1 Infected Treatment Naive Patients
ClinicalTrials.gov study NCT04620304. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Subcutaneous Tissue Irrigation With Povidone Iodine in Decreasing the Rate of Surgical Site Infection Following Cesarean Section
ClinicalTrials.gov study NCT03549702. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Relationship Between Preoperative Subcutaneous Trochanteric Fat Thickness and Postoperative Infection Risk
ClinicalTrials.gov study NCT06428760. IPD Sharing: NO. Countries: 1. Publications: 0.
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
ClinicalTrials.gov study NCT07311395. IPD Sharing: NO. Countries: 1. Publications: 0.
Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration
ClinicalTrials.gov study NCT03177369. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.