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7 results for “subset tracing”
Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
<p><span>The clinical potential of miRNA-based liquid biopsy has been largely limited by the heterogeneous sources in plasma and tedious assay processes. </span><span>Here we develop a precise and robust one-pot assay called dual-surface-protein</span><span>-guided</span><span> orthogonal recognition of tumor-derived exosomes and in-situ profiling of microRNAs (SORTER) to detect tumor-derived exosomal miRNAs and enhance the diagnostic accuracy of prostate cancer (PCa). The SORTER utilizes two allosteric aptamers against exosomal marker CD63 and tumor marker EpCAM to create an orthogonal labeling barcode and achieve selective sorting of tumor-specific exosome subtypes. Furthermore, the labeled barcode on tumor-derived exosomes initiated targeted membrane fusion with liposome probes to import miRNA detection reagents, enabling in-situ sensitive profiling of tumor-derived exosomal miRNAs. With a signature of six miRNAs, SORTER differentiated PCa and benign prostatic hyperplasia with an accuracy of 100%. Notably, the diagnostic accuracy reached 90.6% in the classification of metastatic and non-metastatic PCa. We envision that the SORTER will promote the clinical adaptability of miRNA-based liquid biopsy.</span></p>
Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
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RNA-seq of medullary thymic epithelial cell (mTEC) subsets in inducible Aire-lineage tracing mice
GEO Series GSE114651. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing profile of progeny of a unique mesenchymal progenitor subset traced to adult mouse skeletal muscle
GEO Series GSE180416. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
OMI/Aura Level 2 Nitrogen Dioxide (NO2) Trace Gas Column Data 1-Orbit subset Swath along CloudSat track 1-Orbit Swath 13x24 km
This is a CloudSat-collocated subset of the original product OMNO2, for the purposes of the A-Train mission. The goal of the subset is to select and return OMI data that are within +/-100 km across the CloudSat track. The resultant OMI subset swath is sought to be about 200 km cross-track of CloudSat. This product also contains many ancillary and derived parameters, terrain and geolocation information, solar and satellite viewing angles, and quality flags. Even though collocated with CloudSat, this subset can serve many other A-Train applications. (The shortname for this CloudSat-collocated OMI Level 2 NO2 subset is OMNO2_CPR_V003)
OMI/Aura Level 2 Sulphur Dioxide (SO2) Trace Gas Column Data 1-Orbit Subset and Collocated Swath along CloudSat V003 (OMSO2_CPR) at GES DISC
This is a CloudSat-collocated subset of the original product OMSO2, for the purposes of the A-Train mission. The goal of the subset is to select and return OMI data that are within +/-100 km across the CloudSat track. The resultant OMI subset swath is sought to be about 200 km cross-track of CloudSat. Even though collocated with CloudSat, this subset can serve many other A-Train applications. (The shortname for this CloudSat-collocated subset of the original product OMSO2 Product is OMSO2_CPR_V003) This document describes the original OMI SO2 product (OMSO2) produced from global mode UV measurements of the Ozone Monitoring Instrument (OMI). OMI was launched on July 15, 2004 on the EOS Aura satellite, which is in a sun-synchronous ascending polar orbit with 1:45pm local equator crossing time. The data collection started on August 17, 2004 (orbit 482) and continues to this day with only minor data gaps. The minimum SO2 mass detectable by OMI is about two orders of magnitude smaller than the detection threshold of the legacy Total Ozone Mapping Spectrometer (TOMS) SO2 data (1978-2005) [Krueger et al 1995]. This is due to smaller OMI footprint and the use of wavelengths better optimized for separating O3 from SO2. The product file, called a data granule, covers the sunlit portion of the orbit with an approximately 2600 km wide swath containing 60 pixels per viewing line. During normal operations, 14 or 15 granules are produced daily, providing fully contiguous coverage of the globe. Currently, OMSO2 products are not produced when OMI goes into the "zoom mode" for one day every 452 orbits (~32 days). For each OMI pixel we provide 4 different estimates of the column density of SO2 in Dobson Units (1DU=2.69x10^16 molecules/cm2) obtained by making different assumptions about the vertical distribution of the SO2. However, it is important to note that in most cases the precise vertical distribution of SO2 is unimportant. The users can use either the SO2 plume height, or the center of mass altitude (CMA) derived from SO2 vertical distribution, to interpolate between the 4 values: 1)Planetary Boundary Layer (PBL) SO2 column (ColumnAmountSO2_PBL), corresponding to CMA of 0.9 km. 2)Lower tropospheric SO2 column (ColumnAmountSO2_TRL), corresponding to CMA of 2.5 km. 3)Middle tropospheric SO2 column, (ColumnAmountSO2_TRM), usually produced by volcanic degassing, corresponding to CMA of 7.5 km, 4)Upper tropospheric and Stratospheric SO2 column (ColumnAmountSO2_STL), usually produced by explosive volcanic eruption, corresponding to CMA of 17 km. The accuracy and precision of the derived SO2 columns vary significantly with the SO2 CMA and column amount, observational geometry, and slant column ozone. OMI becomes more sensitive to SO2 above clouds and snow/ice, and less sensitive to SO2 below clouds. Preliminary error estimates are discussed below (see Data Quality Assessment). OMSO2 files are stored in EOS Hierarchical Data Format (HDF-EOS5). Each file contains data from the day lit portion of an orbit (53 minutes). There are approximately 14 orbits per day. The maximum file size for the OMSO2 data product is about 9 Mbytes.
Single-cell transcriptomic phenotyping combined with lineage tracing using paired B cell receptor repertoires identified both persistent antibody-secreting cell as well as memory B cell subsets after
GEO Series GSE149133. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.